D3YPJ7 · D3YPJ7_HHV1
- ProteinRibonucleoside-diphosphate reductase large subunit
- GeneUL39
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids1137 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.
Ribonucleoside-diphosphate reductase holoenzyme provides the precursors necessary for viral DNA synthesis. Allows virus growth in non-dividing cells, as well as reactivation from latency in infected hosts. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.
Catalytic activity
- a 2'-deoxyribonucleoside 5'-diphosphate + [thioredoxin]-disulfide + H2O = a ribonucleoside 5'-diphosphate + [thioredoxin]-dithiol
CHEBI:73316 + RHEA-COMP:10700 CHEBI:50058 Position: n/n+3+ CHEBI:15377 = CHEBI:57930 + RHEA-COMP:10698 CHEBI:29950 Position: nCHEBI:29950 Position: n+3
Features
Showing features for binding site, site, active site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 566 | substrate | ||||
Sequence: T | ||||||
Binding site | 581-582 | substrate | ||||
Sequence: SC | ||||||
Site | 582 | Important for hydrogen atom transfer | ||||
Sequence: C | ||||||
Binding site | 612 | substrate | ||||
Sequence: G | ||||||
Active site | 791 | Proton acceptor | ||||
Sequence: N | ||||||
Binding site | 791-795 | substrate | ||||
Sequence: NLCTE | ||||||
Active site | 793 | Cysteine radical intermediate | ||||
Sequence: C | ||||||
Active site | 795 | Proton acceptor | ||||
Sequence: E | ||||||
Site | 808 | Important for hydrogen atom transfer | ||||
Sequence: C | ||||||
Binding site | 968-972 | substrate | ||||
Sequence: PTAAS | ||||||
Site | 1111 | Important for electron transfer | ||||
Sequence: Y | ||||||
Site | 1112 | Important for electron transfer | ||||
Sequence: Y | ||||||
Site | 1132 | Interacts with thioredoxin/glutaredoxin | ||||
Sequence: C | ||||||
Site | 1135 | Interacts with thioredoxin/glutaredoxin | ||||
Sequence: C |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | ribonucleoside-diphosphate reductase complex | |
Molecular Function | ATP binding | |
Molecular Function | ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor | |
Biological Process | deoxyribonucleotide biosynthetic process | |
Biological Process | DNA replication | |
Biological Process | viral process |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameRibonucleoside-diphosphate reductase large subunit
- EC number
- Short namesR1
- Alternative names
Gene names
Organism names
- Strains
- Taxonomic lineageViruses > Duplodnaviria > Heunggongvirae > Peploviricota > Herviviricetes > Herpesvirales > Orthoherpesviridae > Alphaherpesvirinae > Simplexvirus > Simplexvirus humanalpha1
- Virus hosts
Accessions
- Primary accessionD3YPJ7
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
PTM/Processing
Features
Showing features for disulfide bond.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Disulfide bond | 582↔808 | Redox-active | ||||
Sequence: CYLVNPQATTNKATLRAITSNVSAILARNGGIGLCVQAFNDSGPGTASVMPALKVLDSLVAAHNKESARPTGACVYLEPWHTDVRAVLRMKGVLAGEEAQRCDNIFSALWMPDLFFKRLIRHLDGEKNVTWTLFDRDTSMSLADFHGEEFEKLYQHLEVMGFGEQIPIQELAYGIVRSAATTGSPFVMFKDAVNRHYIYDTQGAAIAGSNLCTEIVHPASKRSSGVC |
Keywords
- PTM
Expression
Keywords
- Developmental stage
Interaction
Subunit
Heterotetramer composed of a homodimer of the large subunit (R1) and a homodimer of the small subunit (R2). Larger multisubunit protein complex are also active, composed of (R1)n(R2)n.
Family & Domains
Features
Showing features for region, compositional bias, domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 1-32 | Disordered | ||||
Sequence: MASRPAASSPVEARAPVGGQEAGGPSAATQGE | ||||||
Region | 124-159 | Disordered | ||||
Sequence: GGTPRRSAGTSTGTQTADVPTEALGGPPPPPRFTLG | ||||||
Compositional bias | 128-142 | Polar residues | ||||
Sequence: RRSAGTSTGTQTADV | ||||||
Region | 173-315 | Disordered | ||||
Sequence: AVFGGEGDPVGPAEFVSDDRSSDSDSDDSEDTDSETLSHASSDVSGGATYDDALDSDSSSDDSLQIDGPVCRPWSNDTAPLDVCPGTPGPGADAGGPSAVDPHAPTPEAGAGLAADPAVARDDAEGLSDPRPRLGTGTAYPVP | ||||||
Domain | 946-968 | Ribonucleotide reductase large subunit | ||||
Sequence: WEMLRQSMMKHGLRNSQFVALMP |
Sequence similarities
Belongs to the ribonucleoside diphosphate reductase large chain family.
Family and domain databases
Sequence
- Sequence statusComplete
- Length1,137
- Mass (Da)123,993
- Last updated2010-04-20 v1
- Checksum776BCEC51E8B707D
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 128-142 | Polar residues | ||||
Sequence: RRSAGTSTGTQTADV |
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
GU734772 EMBL· GenBank· DDBJ | ADD60115.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JN420340 EMBL· GenBank· DDBJ | AER37905.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JN420342 EMBL· GenBank· DDBJ | AER38046.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JQ730035 EMBL· GenBank· DDBJ | AFK50386.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JX142173 EMBL· GenBank· DDBJ | AFP86403.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KR011274 EMBL· GenBank· DDBJ | AKG59222.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KR011275 EMBL· GenBank· DDBJ | AKG59294.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KR011276 EMBL· GenBank· DDBJ | AKG59367.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KR011277 EMBL· GenBank· DDBJ | AKG59439.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KR011278 EMBL· GenBank· DDBJ | AKG59511.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KR011279 EMBL· GenBank· DDBJ | AKG59586.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KR011280 EMBL· GenBank· DDBJ | AKG59658.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KR011281 EMBL· GenBank· DDBJ | AKG59731.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KR011282 EMBL· GenBank· DDBJ | AKG59802.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KR011283 EMBL· GenBank· DDBJ | AKG59874.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KR011284 EMBL· GenBank· DDBJ | AKG59948.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KR011285 EMBL· GenBank· DDBJ | AKG60022.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KR011286 EMBL· GenBank· DDBJ | AKG60094.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KR011287 EMBL· GenBank· DDBJ | AKG60165.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KR011288 EMBL· GenBank· DDBJ | AKG60238.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KR011289 EMBL· GenBank· DDBJ | AKG60311.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KR011290 EMBL· GenBank· DDBJ | AKG60381.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KR011291 EMBL· GenBank· DDBJ | AKG60451.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KR011292 EMBL· GenBank· DDBJ | AKG60523.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KR011293 EMBL· GenBank· DDBJ | AKG60596.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KR011294 EMBL· GenBank· DDBJ | AKG60669.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KR011295 EMBL· GenBank· DDBJ | AKG60740.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KR011296 EMBL· GenBank· DDBJ | AKG60812.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KR011297 EMBL· GenBank· DDBJ | AKG60882.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KR011298 EMBL· GenBank· DDBJ | AKG60954.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KR011299 EMBL· GenBank· DDBJ | AKG61027.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KR011300 EMBL· GenBank· DDBJ | AKG61099.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KR011301 EMBL· GenBank· DDBJ | AKG61170.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KR011302 EMBL· GenBank· DDBJ | AKG61243.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KR011303 EMBL· GenBank· DDBJ | AKG61316.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KR011304 EMBL· GenBank· DDBJ | AKG61387.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KR011305 EMBL· GenBank· DDBJ | AKG61459.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KR011306 EMBL· GenBank· DDBJ | AKG61532.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KR011307 EMBL· GenBank· DDBJ | AKG61606.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KR011308 EMBL· GenBank· DDBJ | AKG61679.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KR011309 EMBL· GenBank· DDBJ | AKG61751.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KR011310 EMBL· GenBank· DDBJ | AKG61823.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KR011311 EMBL· GenBank· DDBJ | AKG61897.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KR011312 EMBL· GenBank· DDBJ | AKG61969.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KR052507 EMBL· GenBank· DDBJ | AKH80439.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KR052508 EMBL· GenBank· DDBJ | AKH80512.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KT425107 EMBL· GenBank· DDBJ | ALM22608.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KX265022 EMBL· GenBank· DDBJ | ANN83937.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KX265024 EMBL· GenBank· DDBJ | ANN84090.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KX265025 EMBL· GenBank· DDBJ | ANN84167.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KX265026 EMBL· GenBank· DDBJ | ANN84244.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KX265027 EMBL· GenBank· DDBJ | ANN84321.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KX265028 EMBL· GenBank· DDBJ | ANN84398.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KX265029 EMBL· GenBank· DDBJ | ANN84473.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KX265030 EMBL· GenBank· DDBJ | ANN84550.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KX265031 EMBL· GenBank· DDBJ | ANN84627.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KX265033 EMBL· GenBank· DDBJ | ANN84780.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KX265034 EMBL· GenBank· DDBJ | ANN84856.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KX265035 EMBL· GenBank· DDBJ | ANN84933.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KX265036 EMBL· GenBank· DDBJ | ANN85009.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KX265037 EMBL· GenBank· DDBJ | ANN85086.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KX265038 EMBL· GenBank· DDBJ | ANN85162.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KX265039 EMBL· GenBank· DDBJ | ANN85237.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KX265040 EMBL· GenBank· DDBJ | ANN85314.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KX265041 EMBL· GenBank· DDBJ | ANN85391.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KX265042 EMBL· GenBank· DDBJ | ANN85467.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KX265043 EMBL· GenBank· DDBJ | ANN85544.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KX265044 EMBL· GenBank· DDBJ | ANN85621.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KX265045 EMBL· GenBank· DDBJ | ANN85698.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KX265046 EMBL· GenBank· DDBJ | ANN85774.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KX791854 EMBL· GenBank· DDBJ | AOY34171.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KX946970 EMBL· GenBank· DDBJ | AOY36658.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MH160361 EMBL· GenBank· DDBJ | AWO69351.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MH160366 EMBL· GenBank· DDBJ | AWO69840.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MH160382 EMBL· GenBank· DDBJ | AWO71310.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MH160387 EMBL· GenBank· DDBJ | AWO71778.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MG999841 EMBL· GenBank· DDBJ | AWW08134.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MG999865 EMBL· GenBank· DDBJ | AWW10320.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MG999871 EMBL· GenBank· DDBJ | AWW10843.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MG999882 EMBL· GenBank· DDBJ | AWW11890.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MG999894 EMBL· GenBank· DDBJ | AWW12949.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MG999899 EMBL· GenBank· DDBJ | AWW13402.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MK952183 EMBL· GenBank· DDBJ | QFQ61259.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MK952184 EMBL· GenBank· DDBJ | QFQ61333.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MK952185 EMBL· GenBank· DDBJ | QFQ61410.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
LT594111 EMBL· GenBank· DDBJ | SBS69570.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
LT594457 EMBL· GenBank· DDBJ | SBT69369.1 EMBL· GenBank· DDBJ | Genomic DNA |