D3YPJ7 · D3YPJ7_HHV1

Function

function

Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.
Ribonucleoside-diphosphate reductase holoenzyme provides the precursors necessary for viral DNA synthesis. Allows virus growth in non-dividing cells, as well as reactivation from latency in infected hosts. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.

Catalytic activity

Features

Showing features for binding site, site, active site.

111371002003004005006007008009001,0001,100
TypeIDPosition(s)Description
Binding site566substrate
Binding site581-582substrate
Site582Important for hydrogen atom transfer
Binding site612substrate
Active site791Proton acceptor
Binding site791-795substrate
Active site793Cysteine radical intermediate
Active site795Proton acceptor
Site808Important for hydrogen atom transfer
Binding site968-972substrate
Site1111Important for electron transfer
Site1112Important for electron transfer
Site1132Interacts with thioredoxin/glutaredoxin
Site1135Interacts with thioredoxin/glutaredoxin

GO annotations

AspectTerm
Cellular Componentribonucleoside-diphosphate reductase complex
Molecular FunctionATP binding
Molecular Functionribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor
Biological Processdeoxyribonucleotide biosynthetic process
Biological ProcessDNA replication
Biological Processviral process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Ribonucleoside-diphosphate reductase large subunit
  • EC number
  • Short names
    R1
  • Alternative names
    • Ribonucleotide reductase large subunit

Gene names

    • Name
      UL39
    • Synonyms
      RIR1
    • ORF names
      HHV1gp057
      , hmpv207_0039

Organism names

Accessions

  • Primary accession
    D3YPJ7

Proteomes

PTM/Processing

Features

Showing features for disulfide bond.

TypeIDPosition(s)Description
Disulfide bond582↔808Redox-active

Keywords

Expression

Keywords

Interaction

Subunit

Heterotetramer composed of a homodimer of the large subunit (R1) and a homodimer of the small subunit (R2). Larger multisubunit protein complex are also active, composed of (R1)n(R2)n.

Structure

3D structure databases

Family & Domains

Features

Showing features for region, compositional bias, domain.

TypeIDPosition(s)Description
Region1-32Disordered
Region124-159Disordered
Compositional bias128-142Polar residues
Region173-315Disordered
Domain946-968Ribonucleotide reductase large subunit

Sequence similarities

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    1,137
  • Mass (Da)
    123,993
  • Last updated
    2010-04-20 v1
  • Checksum
    776BCEC51E8B707D
MASRPAASSPVEARAPVGGQEAGGPSAATQGEAAGAPLAHGHHVYCQRVNGVMVLSDKTPGSASYRISDSNFVQCGSNCTMIIDGDVVRGRPQDPGAAASPAPFVAVTNIGAGSDGGTAVVAFGGTPRRSAGTSTGTQTADVPTEALGGPPPPPRFTLGGGCCSCRDTRRRSAVFGGEGDPVGPAEFVSDDRSSDSDSDDSEDTDSETLSHASSDVSGGATYDDALDSDSSSDDSLQIDGPVCRPWSNDTAPLDVCPGTPGPGADAGGPSAVDPHAPTPEAGAGLAADPAVARDDAEGLSDPRPRLGTGTAYPVPLELTPENAEAVARFLGDAVNREPALMLEYFCRCAREETKRVPPRTFGSPPRLTEDDFGLLNYALVEMQRLCLDVPPVPPNAYMPYYLREYVTRLVNGFKPLVSRSARLYRILGVLVHLRIRTREASFEEWLRSKEVALDFGLTERLREHEAQLVILAQALDHYDCLIHSTPHTLVERGLQSALKYEEFYLKRFGGHYMESVFQMYTRIAGFLACRATRGMRHIALGREGSWWEMFKFFFHRLYDHQIVPSTPAMLNLGTRNYYTSSCYLVNPQATTNKATLRAITSNVSAILARNGGIGLCVQAFNDSGPGTASVMPALKVLDSLVAAHNKESARPTGACVYLEPWHTDVRAVLRMKGVLAGEEAQRCDNIFSALWMPDLFFKRLIRHLDGEKNVTWTLFDRDTSMSLADFHGEEFEKLYQHLEVMGFGEQIPIQELAYGIVRSAATTGSPFVMFKDAVNRHYIYDTQGAAIAGSNLCTEIVHPASKRSSGVCNLGSVNLARCVSRQTFDFGRLRDAVQACVLMVNIMIDSTLQPTPQCTRGNDNLRSMGIGMQGLHTACLKLGLDLESAEFQDLNKHIAEVMLLSAMKTSNALCVRGARPFNHFKRSMYRAGRFHWERFPDARPRYEGEWEMLRQSMMKHGLRNSQFVALMPTAASAQISDVSEGFAPLFTNLFSKVTRDGETLRPNTLLLKELERTFSGKRLLEVMDSLDAKQWSVAQALPCLEPTHPLRRFKTAFDYDQKLLIDLCADRAPYVDHSQSMTLYVTEKADGTLPASTLVRLLVHAYKRGLKTGMYYCKVRKATNSGVFGGDDNIVCTSCAL

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias128-142Polar residues

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
GU734772
EMBL· GenBank· DDBJ
ADD60115.1
EMBL· GenBank· DDBJ
Genomic DNA
JN420340
EMBL· GenBank· DDBJ
AER37905.1
EMBL· GenBank· DDBJ
Genomic DNA
JN420342
EMBL· GenBank· DDBJ
AER38046.1
EMBL· GenBank· DDBJ
Genomic DNA
JQ730035
EMBL· GenBank· DDBJ
AFK50386.1
EMBL· GenBank· DDBJ
Genomic DNA
JX142173
EMBL· GenBank· DDBJ
AFP86403.1
EMBL· GenBank· DDBJ
Genomic DNA
KR011274
EMBL· GenBank· DDBJ
AKG59222.1
EMBL· GenBank· DDBJ
Genomic DNA
KR011275
EMBL· GenBank· DDBJ
AKG59294.1
EMBL· GenBank· DDBJ
Genomic DNA
KR011276
EMBL· GenBank· DDBJ
AKG59367.1
EMBL· GenBank· DDBJ
Genomic DNA
KR011277
EMBL· GenBank· DDBJ
AKG59439.1
EMBL· GenBank· DDBJ
Genomic DNA
KR011278
EMBL· GenBank· DDBJ
AKG59511.1
EMBL· GenBank· DDBJ
Genomic DNA
KR011279
EMBL· GenBank· DDBJ
AKG59586.1
EMBL· GenBank· DDBJ
Genomic DNA
KR011280
EMBL· GenBank· DDBJ
AKG59658.1
EMBL· GenBank· DDBJ
Genomic DNA
KR011281
EMBL· GenBank· DDBJ
AKG59731.1
EMBL· GenBank· DDBJ
Genomic DNA
KR011282
EMBL· GenBank· DDBJ
AKG59802.1
EMBL· GenBank· DDBJ
Genomic DNA
KR011283
EMBL· GenBank· DDBJ
AKG59874.1
EMBL· GenBank· DDBJ
Genomic DNA
KR011284
EMBL· GenBank· DDBJ
AKG59948.1
EMBL· GenBank· DDBJ
Genomic DNA
KR011285
EMBL· GenBank· DDBJ
AKG60022.1
EMBL· GenBank· DDBJ
Genomic DNA
KR011286
EMBL· GenBank· DDBJ
AKG60094.1
EMBL· GenBank· DDBJ
Genomic DNA
KR011287
EMBL· GenBank· DDBJ
AKG60165.1
EMBL· GenBank· DDBJ
Genomic DNA
KR011288
EMBL· GenBank· DDBJ
AKG60238.1
EMBL· GenBank· DDBJ
Genomic DNA
KR011289
EMBL· GenBank· DDBJ
AKG60311.1
EMBL· GenBank· DDBJ
Genomic DNA
KR011290
EMBL· GenBank· DDBJ
AKG60381.1
EMBL· GenBank· DDBJ
Genomic DNA
KR011291
EMBL· GenBank· DDBJ
AKG60451.1
EMBL· GenBank· DDBJ
Genomic DNA
KR011292
EMBL· GenBank· DDBJ
AKG60523.1
EMBL· GenBank· DDBJ
Genomic DNA
KR011293
EMBL· GenBank· DDBJ
AKG60596.1
EMBL· GenBank· DDBJ
Genomic DNA
KR011294
EMBL· GenBank· DDBJ
AKG60669.1
EMBL· GenBank· DDBJ
Genomic DNA
KR011295
EMBL· GenBank· DDBJ
AKG60740.1
EMBL· GenBank· DDBJ
Genomic DNA
KR011296
EMBL· GenBank· DDBJ
AKG60812.1
EMBL· GenBank· DDBJ
Genomic DNA
KR011297
EMBL· GenBank· DDBJ
AKG60882.1
EMBL· GenBank· DDBJ
Genomic DNA
KR011298
EMBL· GenBank· DDBJ
AKG60954.1
EMBL· GenBank· DDBJ
Genomic DNA
KR011299
EMBL· GenBank· DDBJ
AKG61027.1
EMBL· GenBank· DDBJ
Genomic DNA
KR011300
EMBL· GenBank· DDBJ
AKG61099.1
EMBL· GenBank· DDBJ
Genomic DNA
KR011301
EMBL· GenBank· DDBJ
AKG61170.1
EMBL· GenBank· DDBJ
Genomic DNA
KR011302
EMBL· GenBank· DDBJ
AKG61243.1
EMBL· GenBank· DDBJ
Genomic DNA
KR011303
EMBL· GenBank· DDBJ
AKG61316.1
EMBL· GenBank· DDBJ
Genomic DNA
KR011304
EMBL· GenBank· DDBJ
AKG61387.1
EMBL· GenBank· DDBJ
Genomic DNA
KR011305
EMBL· GenBank· DDBJ
AKG61459.1
EMBL· GenBank· DDBJ
Genomic DNA
KR011306
EMBL· GenBank· DDBJ
AKG61532.1
EMBL· GenBank· DDBJ
Genomic DNA
KR011307
EMBL· GenBank· DDBJ
AKG61606.1
EMBL· GenBank· DDBJ
Genomic DNA
KR011308
EMBL· GenBank· DDBJ
AKG61679.1
EMBL· GenBank· DDBJ
Genomic DNA
KR011309
EMBL· GenBank· DDBJ
AKG61751.1
EMBL· GenBank· DDBJ
Genomic DNA
KR011310
EMBL· GenBank· DDBJ
AKG61823.1
EMBL· GenBank· DDBJ
Genomic DNA
KR011311
EMBL· GenBank· DDBJ
AKG61897.1
EMBL· GenBank· DDBJ
Genomic DNA
KR011312
EMBL· GenBank· DDBJ
AKG61969.1
EMBL· GenBank· DDBJ
Genomic DNA
KR052507
EMBL· GenBank· DDBJ
AKH80439.1
EMBL· GenBank· DDBJ
Genomic DNA
KR052508
EMBL· GenBank· DDBJ
AKH80512.1
EMBL· GenBank· DDBJ
Genomic DNA
KT425107
EMBL· GenBank· DDBJ
ALM22608.1
EMBL· GenBank· DDBJ
Genomic DNA
KX265022
EMBL· GenBank· DDBJ
ANN83937.1
EMBL· GenBank· DDBJ
Genomic DNA
KX265024
EMBL· GenBank· DDBJ
ANN84090.1
EMBL· GenBank· DDBJ
Genomic DNA
KX265025
EMBL· GenBank· DDBJ
ANN84167.1
EMBL· GenBank· DDBJ
Genomic DNA
KX265026
EMBL· GenBank· DDBJ
ANN84244.1
EMBL· GenBank· DDBJ
Genomic DNA
KX265027
EMBL· GenBank· DDBJ
ANN84321.1
EMBL· GenBank· DDBJ
Genomic DNA
KX265028
EMBL· GenBank· DDBJ
ANN84398.1
EMBL· GenBank· DDBJ
Genomic DNA
KX265029
EMBL· GenBank· DDBJ
ANN84473.1
EMBL· GenBank· DDBJ
Genomic DNA
KX265030
EMBL· GenBank· DDBJ
ANN84550.1
EMBL· GenBank· DDBJ
Genomic DNA
KX265031
EMBL· GenBank· DDBJ
ANN84627.1
EMBL· GenBank· DDBJ
Genomic DNA
KX265033
EMBL· GenBank· DDBJ
ANN84780.1
EMBL· GenBank· DDBJ
Genomic DNA
KX265034
EMBL· GenBank· DDBJ
ANN84856.1
EMBL· GenBank· DDBJ
Genomic DNA
KX265035
EMBL· GenBank· DDBJ
ANN84933.1
EMBL· GenBank· DDBJ
Genomic DNA
KX265036
EMBL· GenBank· DDBJ
ANN85009.1
EMBL· GenBank· DDBJ
Genomic DNA
KX265037
EMBL· GenBank· DDBJ
ANN85086.1
EMBL· GenBank· DDBJ
Genomic DNA
KX265038
EMBL· GenBank· DDBJ
ANN85162.1
EMBL· GenBank· DDBJ
Genomic DNA
KX265039
EMBL· GenBank· DDBJ
ANN85237.1
EMBL· GenBank· DDBJ
Genomic DNA
KX265040
EMBL· GenBank· DDBJ
ANN85314.1
EMBL· GenBank· DDBJ
Genomic DNA
KX265041
EMBL· GenBank· DDBJ
ANN85391.1
EMBL· GenBank· DDBJ
Genomic DNA
KX265042
EMBL· GenBank· DDBJ
ANN85467.1
EMBL· GenBank· DDBJ
Genomic DNA
KX265043
EMBL· GenBank· DDBJ
ANN85544.1
EMBL· GenBank· DDBJ
Genomic DNA
KX265044
EMBL· GenBank· DDBJ
ANN85621.1
EMBL· GenBank· DDBJ
Genomic DNA
KX265045
EMBL· GenBank· DDBJ
ANN85698.1
EMBL· GenBank· DDBJ
Genomic DNA
KX265046
EMBL· GenBank· DDBJ
ANN85774.1
EMBL· GenBank· DDBJ
Genomic DNA
KX791854
EMBL· GenBank· DDBJ
AOY34171.1
EMBL· GenBank· DDBJ
Genomic DNA
KX946970
EMBL· GenBank· DDBJ
AOY36658.1
EMBL· GenBank· DDBJ
Genomic DNA
MH160361
EMBL· GenBank· DDBJ
AWO69351.1
EMBL· GenBank· DDBJ
Genomic DNA
MH160366
EMBL· GenBank· DDBJ
AWO69840.1
EMBL· GenBank· DDBJ
Genomic DNA
MH160382
EMBL· GenBank· DDBJ
AWO71310.1
EMBL· GenBank· DDBJ
Genomic DNA
MH160387
EMBL· GenBank· DDBJ
AWO71778.1
EMBL· GenBank· DDBJ
Genomic DNA
MG999841
EMBL· GenBank· DDBJ
AWW08134.1
EMBL· GenBank· DDBJ
Genomic DNA
MG999865
EMBL· GenBank· DDBJ
AWW10320.1
EMBL· GenBank· DDBJ
Genomic DNA
MG999871
EMBL· GenBank· DDBJ
AWW10843.1
EMBL· GenBank· DDBJ
Genomic DNA
MG999882
EMBL· GenBank· DDBJ
AWW11890.1
EMBL· GenBank· DDBJ
Genomic DNA
MG999894
EMBL· GenBank· DDBJ
AWW12949.1
EMBL· GenBank· DDBJ
Genomic DNA
MG999899
EMBL· GenBank· DDBJ
AWW13402.1
EMBL· GenBank· DDBJ
Genomic DNA
MK952183
EMBL· GenBank· DDBJ
QFQ61259.1
EMBL· GenBank· DDBJ
Genomic DNA
MK952184
EMBL· GenBank· DDBJ
QFQ61333.1
EMBL· GenBank· DDBJ
Genomic DNA
MK952185
EMBL· GenBank· DDBJ
QFQ61410.1
EMBL· GenBank· DDBJ
Genomic DNA
LT594111
EMBL· GenBank· DDBJ
SBS69570.1
EMBL· GenBank· DDBJ
Genomic DNA
LT594457
EMBL· GenBank· DDBJ
SBT69369.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

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