D3VY07 · D3VY07_9CNID
- ProteinNADH:ubiquinone reductase (H(+)-translocating)
- GeneND2
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids188 (go to sequence)
- Protein existenceInferred from homology
- Annotation score2/5
Function
function
Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
Catalytic activity
- a ubiquinone + 5 H+(in) + NADH = a ubiquinol + 4 H+(out) + NAD+
a ubiquinone RHEA-COMP:9565 + 5 H+ (in)CHEBI:15378+ CHEBI:57945 = a ubiquinol RHEA-COMP:9566 + 4 H+ (out)CHEBI:15378+ CHEBI:57540
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | membrane | |
Cellular Component | mitochondrion | |
Molecular Function | NADH dehydrogenase (ubiquinone) activity |
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameNADH:ubiquinone reductase (H(+)-translocating)
- EC number
Gene names
Encoded on
- Mitochondrion
Organism names
- Taxonomic lineageEukaryota > Metazoa > Cnidaria > Anthozoa > Octocorallia > Scleralcyonacea > Coralliidae > Paragorgia
Accessions
- Primary accessionD3VY07
Subcellular Location
UniProt Annotation
GO Annotation
Membrane ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 6-26 | Helical | ||||
Sequence: PWHPMELTLGLIILIVLMYGL | ||||||
Transmembrane | 33-51 | Helical | ||||
Sequence: LAIFCLGVTLLMGAAGLLA | ||||||
Transmembrane | 57-77 | Helical | ||||
Sequence: CWTQAIKMLVMLSGLAILCML | ||||||
Transmembrane | 89-113 | Helical | ||||
Sequence: LILLVILGNLLLIGSTNLILIYLAL | ||||||
Transmembrane | 140-162 | Helical | ||||
Sequence: YFVLGALSSGLFLFGCALIYGST |
Keywords
- Cellular component
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 10-100 | NADH dehydrogenase subunit 2 N-terminal | ||||
Sequence: MELTLGLIILIVLMYGLKAPTLRLAIFCLGVTLLMGAAGLLAEPHLLCWTQAIKMLVMLSGLAILCMLDHRTSHQSSSLLILLVILGNLLL | ||||||
Domain | 103-173 | NADH:quinone oxidoreductase/Mrp antiporter membrane subunit | ||||
Sequence: STNLILIYLALEMQTLCMFILVAYNKNSLLSAEAGLKYFVLGALSSGLFLFGCALIYGSTGELELQFIRMS |
Sequence similarities
Belongs to the complex I subunit 2 family.
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusFragment
- Length188
- Mass (Da)20,456
- Last updated2010-04-20 v1
- ChecksumF2D7BA8A4BC2FD29
Features
Showing features for non-terminal residue.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Non-terminal residue | 188 | |||||
Sequence: I |
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
GQ293330 EMBL· GenBank· DDBJ | ADC97822.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JX128447 EMBL· GenBank· DDBJ | AFP28837.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JX128450 EMBL· GenBank· DDBJ | AFP28840.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JX128452 EMBL· GenBank· DDBJ | AFP28842.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JX128453 EMBL· GenBank· DDBJ | AFP28843.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JX128454 EMBL· GenBank· DDBJ | AFP28844.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JX128456 EMBL· GenBank· DDBJ | AFP28846.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JX128458 EMBL· GenBank· DDBJ | AFP28848.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JX128460 EMBL· GenBank· DDBJ | AFP28850.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JX128461 EMBL· GenBank· DDBJ | AFP28851.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JX128463 EMBL· GenBank· DDBJ | AFP28853.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JX128464 EMBL· GenBank· DDBJ | AFP28854.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JX128465 EMBL· GenBank· DDBJ | AFP28855.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JX128468 EMBL· GenBank· DDBJ | AFP28858.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JX128471 EMBL· GenBank· DDBJ | AFP28861.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JX128474 EMBL· GenBank· DDBJ | AFP28864.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JX128475 EMBL· GenBank· DDBJ | AFP28865.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JX128476 EMBL· GenBank· DDBJ | AFP28866.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JX128478 EMBL· GenBank· DDBJ | AFP28868.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JX128480 EMBL· GenBank· DDBJ | AFP28870.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JX128481 EMBL· GenBank· DDBJ | AFP28871.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JX128482 EMBL· GenBank· DDBJ | AFP28872.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JX128484 EMBL· GenBank· DDBJ | AFP28874.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JX128486 EMBL· GenBank· DDBJ | AFP28876.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JX128487 EMBL· GenBank· DDBJ | AFP28877.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JX128492 EMBL· GenBank· DDBJ | AFP28882.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JX128495 EMBL· GenBank· DDBJ | AFP28885.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JX128497 EMBL· GenBank· DDBJ | AFP28887.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JX128500 EMBL· GenBank· DDBJ | AFP28890.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JX128501 EMBL· GenBank· DDBJ | AFP28891.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JX128502 EMBL· GenBank· DDBJ | AFP28892.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JX128505 EMBL· GenBank· DDBJ | AFP28895.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JX128509 EMBL· GenBank· DDBJ | AFP28899.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JX128511 EMBL· GenBank· DDBJ | AFP28901.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JX128513 EMBL· GenBank· DDBJ | AFP28903.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JX128516 EMBL· GenBank· DDBJ | AFP28906.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JX128519 EMBL· GenBank· DDBJ | AFP28909.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JX128522 EMBL· GenBank· DDBJ | AFP28912.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JX128523 EMBL· GenBank· DDBJ | AFP28913.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JX128524 EMBL· GenBank· DDBJ | AFP28914.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JX128526 EMBL· GenBank· DDBJ | AFP28916.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JX128527 EMBL· GenBank· DDBJ | AFP28917.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JX128529 EMBL· GenBank· DDBJ | AFP28919.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JX128530 EMBL· GenBank· DDBJ | AFP28920.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JX128532 EMBL· GenBank· DDBJ | AFP28922.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JX128535 EMBL· GenBank· DDBJ | AFP28925.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JX128537 EMBL· GenBank· DDBJ | AFP28927.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JX128538 EMBL· GenBank· DDBJ | AFP28928.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JX128542 EMBL· GenBank· DDBJ | AFP28932.1 EMBL· GenBank· DDBJ | Genomic DNA |