D3VMV7 · D3VMV7_MACCN
- ProteinCytochrome c oxidase subunit 1
- GeneCOI
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids219 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
Catalytic activity
- 4 Fe(II)-[cytochrome c] + 8 H+(in) + O2 = 4 Fe(III)-[cytochrome c] + 4 H+(out) + 2 H2OThis reaction proceeds in the forward direction.
4 RHEA-COMP:10350 + 8 H+ (in)CHEBI:15378+ CHEBI:15379 = 4 RHEA-COMP:14399 + 4 H+ (out)CHEBI:15378+ 2 CHEBI:15377
Cofactor
Pathway
Energy metabolism; oxidative phosphorylation.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | mitochondrial respiratory chain complex IV | |
Molecular Function | cytochrome-c oxidase activity | |
Molecular Function | heme binding | |
Molecular Function | metal ion binding | |
Biological Process | electron transport coupled proton transport | |
Biological Process | mitochondrial electron transport, cytochrome c to oxygen |
Keywords
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameCytochrome c oxidase subunit 1
- EC number
Gene names
Encoded on
- Mitochondrion
Organism names
- Taxonomic lineageEukaryota > Metazoa > Ecdysozoa > Arthropoda > Crustacea > Multicrustacea > Malacostraca > Eumalacostraca > Eucarida > Decapoda > Pleocyemata > Caridea > Palaemonoidea > Palaemonidae > Macrobrachium
Accessions
- Primary accessionD3VMV7
Subcellular Location
UniProt Annotation
GO Annotation
Mitochondrion inner membrane ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 6-25 | Helical | ||||
Sequence: FGAWAGMVGTSLSLLIRAEL | ||||||
Transmembrane | 37-59 | Helical | ||||
Sequence: IYNVIVTAHAFVMIFFMVMPIMI | ||||||
Transmembrane | 93-113 | Helical | ||||
Sequence: LTLLLSSGMVESGVGTGWTVY | ||||||
Transmembrane | 133-155 | Helical | ||||
Sequence: SLHLAGVSSILGAVNFITTVINM | ||||||
Transmembrane | 167-194 | Helical | ||||
Sequence: LFVWSVFLTAILLLLSLPVLAGAITMLL |
Keywords
- Cellular component
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 1-219 | Cytochrome oxidase subunit I profile | ||||
Sequence: TLYFIFGAWAGMVGTSLSLLIRAELGQPGSLIGNDQIYNVIVTAHAFVMIFFMVMPIMIGGFGNWLVPLMLGAPDMAFPRMNNMSFWLLPPSLTLLLSSGMVESGVGTGWTVYPPLSAGTAHAGASVDLGIFSLHLAGVSSILGAVNFITTVINMRSPGMSMDRLPLFVWSVFLTAILLLLSLPVLAGAITMLLTDRNLNTSFFDPAGGGDPILYQHLF |
Sequence similarities
Belongs to the heme-copper respiratory oxidase family.
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusFragment
- Length219
- Mass (Da)23,401
- Last updated2010-04-20 v1
- Checksum41D6D1BABAAD323D
Features
Showing features for non-terminal residue.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Non-terminal residue | 1 | |||||
Sequence: T | ||||||
Non-terminal residue | 219 | |||||
Sequence: F |
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
FN668959 EMBL· GenBank· DDBJ | CBJ94405.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
FN668960 EMBL· GenBank· DDBJ | CBJ94406.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
FN668961 EMBL· GenBank· DDBJ | CBJ94407.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
FN668963 EMBL· GenBank· DDBJ | CBJ94409.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
FN668964 EMBL· GenBank· DDBJ | CBJ94410.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
FN668965 EMBL· GenBank· DDBJ | CBJ94411.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
FN668966 EMBL· GenBank· DDBJ | CBJ94412.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
FN668967 EMBL· GenBank· DDBJ | CBJ94413.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
FN668968 EMBL· GenBank· DDBJ | CBJ94414.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
FN668970 EMBL· GenBank· DDBJ | CBJ94416.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
FN668971 EMBL· GenBank· DDBJ | CBJ94417.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
FN668972 EMBL· GenBank· DDBJ | CBJ94418.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
FN668975 EMBL· GenBank· DDBJ | CBJ94421.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
FN668977 EMBL· GenBank· DDBJ | CBJ94423.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
FN668978 EMBL· GenBank· DDBJ | CBJ94424.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
FN668980 EMBL· GenBank· DDBJ | CBJ94426.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
FN668981 EMBL· GenBank· DDBJ | CBJ94427.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
FN668982 EMBL· GenBank· DDBJ | CBJ94428.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
FN668983 EMBL· GenBank· DDBJ | CBJ94429.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
FN668985 EMBL· GenBank· DDBJ | CBJ94431.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
FN668986 EMBL· GenBank· DDBJ | CBJ94432.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
FN668987 EMBL· GenBank· DDBJ | CBJ94433.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
FN668988 EMBL· GenBank· DDBJ | CBJ94434.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
FN668989 EMBL· GenBank· DDBJ | CBJ94435.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
FN668990 EMBL· GenBank· DDBJ | CBJ94436.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
FN668992 EMBL· GenBank· DDBJ | CBJ94438.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
FN668993 EMBL· GenBank· DDBJ | CBJ94439.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
FN668994 EMBL· GenBank· DDBJ | CBJ94440.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
FN668995 EMBL· GenBank· DDBJ | CBJ94441.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
FN668996 EMBL· GenBank· DDBJ | CBJ94442.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
FN668997 EMBL· GenBank· DDBJ | CBJ94443.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
FN668998 EMBL· GenBank· DDBJ | CBJ94444.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
FN668999 EMBL· GenBank· DDBJ | CBJ94445.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
FN669000 EMBL· GenBank· DDBJ | CBJ94446.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
FN669001 EMBL· GenBank· DDBJ | CBJ94447.1 EMBL· GenBank· DDBJ | Genomic DNA |