Essential maintenance is planned to begin on Fri Jan 24 2025. The website may be temporarily unavailable. Please use our fallback: https://wwwdev.ebi.ac.uk/uniprot/front-end/fallback/ in case of any outage.

D3VAI3 · D3VAI3_XENNA

Function

function

Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.

Catalytic activity

Activity regulation

Allosterically activated by N-acetylglucosamine 6-phosphate (GlcNAc6P).

Pathway

Amino-sugar metabolism; N-acetylneuraminate degradation; D-fructose 6-phosphate from N-acetylneuraminate: step 5/5.

Features

Showing features for active site, site.

Type
IDPosition(s)Description
Active site72Proton acceptor; for enolization step
Active site141For ring-opening step
Active site143Proton acceptor; for ring-opening step
Active site148For ring-opening step
Site151Part of the allosteric site
Site158Part of the allosteric site
Site160Part of the allosteric site
Site161Part of the allosteric site

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular Functionglucosamine-6-phosphate deaminase activity
Molecular Functionidentical protein binding
Biological Processcarbohydrate metabolic process
Biological Processglucosamine catabolic process
Biological ProcessN-acetylglucosamine catabolic process
Biological ProcessN-acetylneuraminate catabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Glucosamine-6-phosphate deaminase
  • EC number
  • Alternative names
    • GlcN6P deaminase
      (GNPDA
      )
    • Glucosamine-6-phosphate isomerase

Gene names

    • Name
      nagB
    • Ordered locus names
      XNC1_1356

Organism names

Accessions

  • Primary accession
    D3VAI3

Proteomes

Subcellular Location

Interaction

Subunit

Homohexamer.

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain17-230Glucosamine/galactosamine-6-phosphate isomerase

Sequence similarities

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    268
  • Mass (Da)
    29,955
  • Last updated
    2010-04-20 v1
  • MD5 Checksum
    64B997C0E8312EB00DF15C64E2956B64
MRLIPLTTAGDVGRWSAHYIATKINEFNPTAERPFVLGLPTGSTPLATYRKLITLYQAGKVSFGHVVTFNMDEYIGLPADHPQSYHSFMHQNFFSHIDIPKENINLLNGNAVDIDVECQRYENKIKSYGKIQLFMGGVGNDGHIAFNEPASSLSSRTRIKTLTIETRTANSRFFNNDIAQVPKYALTVGVGTLMDAEEIMILATGMNKAQALQAAIEGHINHMWTVSCLQMHPKSLIVCDEPATMELKVKTVKYFRQLETDIINEFAS

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
FN667742
EMBL· GenBank· DDBJ
CBJ89419.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
Help