D3SXU2 · D3SXU2_NATMM

Function

function

Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.

Catalytic activity

Cofactor

Protein has several cofactor binding sites:
Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

a divalent metal cation (UniProtKB | Rhea| CHEBI:60240 )

Features

Showing features for active site, binding site.

TypeIDPosition(s)Description
Active site65Proton acceptor
Binding site65-66NAD+ (UniProtKB | ChEBI)
Binding site134-135NAD+ (UniProtKB | ChEBI)
Binding site150NAD+ (UniProtKB | ChEBI)
Binding site410Mg2+ 1 (UniProtKB | ChEBI); catalytic
Binding site426Mg2+ 1 (UniProtKB | ChEBI); catalytic
Binding site428Mg2+ 1 (UniProtKB | ChEBI); catalytic
Binding site429Mg2+ 1 (UniProtKB | ChEBI); catalytic
Binding site546Mg2+ 1 (UniProtKB | ChEBI); catalytic

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular FunctionATP binding
Molecular Functioninositol monophosphate 1-phosphatase activity
Molecular Functionmetal ion binding
Molecular FunctionNAD+ kinase activity
Biological Processinositol metabolic process
Biological ProcessNAD metabolic process
Biological ProcessNADP biosynthetic process
Biological Processphosphatidylinositol phosphate biosynthetic process
Biological Processsignal transduction

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    NAD kinase
  • EC number
  • Alternative names
    • ATP-dependent NAD kinase

Gene names

    • Name
      nadK
    • ORF names
      C500_02375
    • Ordered locus names
      Nmag_0394

Organism names

Accessions

  • Primary accession
    D3SXU2

Proteomes

Subcellular Location

Keywords

PTM/Processing

Proteomic databases

Interaction

Protein-protein interaction databases

Family & Domains

Features

Showing features for region, compositional bias.

TypeIDPosition(s)Description
Region305-340Disordered
Compositional bias325-340Polar residues

Sequence similarities

Belongs to the NAD kinase family.
Belongs to the inositol monophosphatase superfamily.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    607
  • Mass (Da)
    64,875
  • Last updated
    2010-04-20 v1
  • Checksum
    C3D8137CC0499808
MQGRRLATTEEIVAIVSPDSDDVVARLESWTAERDISLSTVAVGDDIDHVYDENRATLGVTIGGDGTFFEGIKTFAPRNVPQIGVNTGTLAFLARVEPEDLEAALDEIIHGRAKVDSRQQVVVHGEGIDATGINDVMVEHVPPENPIDRKITQLDVYADDEYIGEFEGTGLAVSTPTGSTGISLSANGPIHYPVDNHTLQLVPLHTHQIGVRPIIVSSSTELRLVTRGPATLLVDGGRANATLETGEEVLITGAERLAHVVRTSYDDHFFTAISKKLGWGIRDVDEPQRQSTTAAREQAGDFAAESVGDDHGLPPGPAPTPSPSRAPGSDSTTPALTDGDSSTVLEHAHTIATEAAEAAGEPLRELHGQVETVDVKSNKSDIVTEADHQANRIITTVIDNEFPDHGIVSEEQPRRNGKNGYTWVVDPLDGTGNFAHGNPNYSISIALLENGTPAMGVVYVPETDELFSAIAGIGAWRDGDPIETTDRDRLDESMLISGYDPDGTFLSHFYQESRGVRRLGSAALNLCYLASGSADATWEHDTYPWDIAGGLVIARAAGATITDERGEPFVFDLATDKRTALLGSNGPLHPALLEHLGTGLPDRSGDR

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias325-340Polar residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP001932
EMBL· GenBank· DDBJ
ADD03982.1
EMBL· GenBank· DDBJ
Genomic DNA
AOHS01000009
EMBL· GenBank· DDBJ
ELY33641.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

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