D3RKJ0 · YMDB_KLEVT
- ProteinO-acetyl-ADP-ribose deacetylase
- GeneymdB
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids175 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Deacetylates O-acetyl-ADP ribose to yield ADP-ribose and free acetate. Down-regulates ribonuclease 3 (RNase III) activity. Acts by interacting directly with the region of the ribonuclease that is required for dimerization/activation.
Catalytic activity
- 3''-O-acetyl-ADP-D-ribose + H2O = acetate + ADP-D-ribose + H+
Features
Showing features for binding site, active site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 11-12 | substrate | ||||
Sequence: DI | ||||||
Binding site | 25 | substrate | ||||
Sequence: N | ||||||
Binding site | 33-35 | substrate | ||||
Sequence: GVD | ||||||
Active site | 35 | Proton acceptor | ||||
Sequence: D | ||||||
Binding site | 122-126 | substrate | ||||
Sequence: STGVY |
GO annotations
Aspect | Term | |
---|---|---|
Molecular Function | O-acetyl-ADP-ribose deacetylase activity | |
Molecular Function | purine nucleoside binding | |
Molecular Function | ribonuclease inhibitor activity | |
Biological Process | purine nucleoside metabolic process |
Keywords
- Molecular function
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameO-acetyl-ADP-ribose deacetylase
- EC number
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageBacteria > Pseudomonadota > Gammaproteobacteria > Enterobacterales > Enterobacteriaceae > Klebsiella/Raoultella group > Klebsiella
Accessions
- Primary accessionD3RKJ0
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000409480 | 1-175 | O-acetyl-ADP-ribose deacetylase | |||
Sequence: MAVQPEVILGDITTLEVDVIVNAANPSLLGGGGVDGAIHRAAGPALLAACKQVLQQQGECPPGHAVITIAGDLPASAVIHTVGPVWHGGDRMEAQTLADAYKNSLQLAAANNYRSIAFPAISTGVYGYPKEEAAEIAVRTVTAFLTRYNPLERVLFVCFDEETAAIYRRLLASYP |
Interaction
Subunit
Homodimer. Interacts with RNase III.
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 1-175 | Macro | ||||
Sequence: MAVQPEVILGDITTLEVDVIVNAANPSLLGGGGVDGAIHRAAGPALLAACKQVLQQQGECPPGHAVITIAGDLPASAVIHTVGPVWHGGDRMEAQTLADAYKNSLQLAAANNYRSIAFPAISTGVYGYPKEEAAEIAVRTVTAFLTRYNPLERVLFVCFDEETAAIYRRLLASYP |
Sequence similarities
Belongs to the YmdB family.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length175
- Mass (Da)18,457
- Last updated2010-04-20 v1
- ChecksumA77CD2C9F8EA3AE1
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
CP001891 EMBL· GenBank· DDBJ | ADC59201.1 EMBL· GenBank· DDBJ | Genomic DNA |