D3JZW5 · D3JZW5_HUMAN

  • Protein
    Parkin RBR E3 ubiquitin protein ligase
  • Gene
    PRKN
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    1/5

Function

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Molecular Functionligase activity

Keywords

Names & Taxonomy

Protein names

  • Submitted names
    • Parkin RBR E3 ubiquitin protein ligase
    • Truncated parkin variant SV4,8DEL
    • Truncated parkin variant SV4DEL
      (EC:6.3.2.19
      )

Gene names

    • Name
      PRKN
    • Synonyms
      PARK2

Organism names

  • Taxonomic identifier
  • Organism
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo

Accessions

  • Primary accession
    D3JZW5

Proteomes

Organism-specific databases

Disease & Variants

Variants

We now provide the "Disease & Variants" viewer in its own tab.

The viewer provides 221 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

Genetic variation databases

Expression

Gene expression databases

Family & Domains

Features

Showing features for domain, region.

TypeIDPosition(s)Description
Domain1-72Ubiquitin-like
Region77-112Disordered
Region124-143Disordered

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    143
  • Mass (Da)
    15,521
  • Last updated
    2010-03-23 v1
  • Checksum
    B97B8299DB799341
MIVFVRFNSSHGFPVEVDSDTSIFQLKEVVAKRQGVPADQLRVIFAGKELRNDWTVQNCDLDQQSIVHIVQRPWRKGQEMNATGGDDPRNAAGGCEREPQSLTRVDLSSSVLPGDSVGLAVILHTDSRKDSPPAGSPGSILLG

Computationally mapped potential isoform sequences

There are 6 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
O60260PRKN_HUMANPRKN465
A0A6I8PII0A0A6I8PII0_HUMANPRKN115
A0A6I8PRS9A0A6I8PRS9_HUMANPRKN63
D3K2X1D3K2X1_HUMANPRKN95
B1AKC3B1AKC3_HUMANPRKN368
A0A669KBE3A0A669KBE3_HUMANPRKN362

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AL035697
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
AL078583
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
AL132982
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
AL138716
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
AL445215
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
KF458345
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
KF458347
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
KF495747
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
GU345838
EMBL· GenBank· DDBJ
ADB90269.1
EMBL· GenBank· DDBJ
mRNA
GU361466
EMBL· GenBank· DDBJ
ADB91978.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

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