D3JZB5 · D3JZB5_9CAUD
- Proteinribonucleoside-triphosphate reductase (thioredoxin)
- Gene53
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids687 (go to sequence)
- Protein existenceInferred from homology
- Annotation score2/5
Function
Catalytic activity
- [thioredoxin]-disulfide + a 2'-deoxyribonucleoside 5'-triphosphate + H2O = [thioredoxin]-dithiol + a ribonucleoside 5'-triphosphate
RHEA-COMP:10700 CHEBI:50058 Position: n/n+3+ CHEBI:61560 + CHEBI:15377 = RHEA-COMP:10698 CHEBI:29950 Position: nCHEBI:29950 Position: n+3+ CHEBI:61557
Cofactor
Features
Showing features for active site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Active site | 372 | |||||
Sequence: C | ||||||
Active site | 374 | |||||
Sequence: E |
GO annotations
Aspect | Term | |
---|---|---|
Molecular Function | cobalamin binding | |
Molecular Function | nucleotide binding | |
Molecular Function | ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor | |
Molecular Function | ribonucleoside-triphosphate reductase activity | |
Biological Process | DNA replication |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameribonucleoside-triphosphate reductase (thioredoxin)
- EC number
Gene names
Organism names
- Organism
- Taxonomic lineageViruses > Duplodnaviria > Heunggongvirae > Uroviricota > Caudoviricetes > Fromanvirus > Fromanvirus redrock
Accessions
- Primary accessionD3JZB5
Proteomes
PTM/Processing
Features
Showing features for disulfide bond.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Disulfide bond | 90↔383 | Redox-active | ||||
Sequence: CWVAGWPEQISGHFEFTFMRLMEGGGVGANYSNHYLDHYGPVQQELFVHIVCDRDHPDYEAMEAAGILSTEYDPDWVGAFEVEDSREGWAAALTDLIDTHYRDEVSHFQRVYDVSRVRPVGAKLKTFGGQASGPQPFAEMLIKVCKILSANVDLPLTGIDAMTIDHAIASCVVAGGVRRSARMSMMHWNDPQIEEFINVKATSGEHWTTNISVEVDDEFWAALKGQSPLWWQEAIGDYTTQEKAERIMEALSVGAVRNGEPGMWDSSLSNVGEPNKVVCTNPCGEITLEPWEPC |
Keywords
- PTM
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 8-80 | Ribonucleotide reductase alpha helical | ||||
Sequence: WGPTGELVYKRTYARTKPDGTKETWPETVERVVDGNLGLVDVRYQLPDERAQLIRLMSEFKILPAGRHLWASG | ||||||
Domain | 139-237 | B12-dependent ribonucleotide reductase insertion | ||||
Sequence: IVCDRDHPDYEAMEAAGILSTEYDPDWVGAFEVEDSREGWAAALTDLIDTHYRDEVSHFQRVYDVSRVRPVGAKLKTFGGQASGPQPFAEMLIKVCKIL | ||||||
Domain | 251-476 | Ribonucleotide reductase large subunit C-terminal | ||||
Sequence: MTIDHAIASCVVAGGVRRSARMSMMHWNDPQIEEFINVKATSGEHWTTNISVEVDDEFWAALKGQSPLWWQEAIGDYTTQEKAERIMEALSVGAVRNGEPGMWDSSLSNVGEPNKVVCTNPCGEITLEPWEPCNLGHINLAAFVTDAGKTDYLDLIRAHRLMTRFLIRATFSAVADPKSREVLDRNRRIGVGHLGVASYLALTGQHYNATAANTRFKKLLRELATE | ||||||
Domain | 498-624 | Ribonucleotide reductase large subunit C-terminal | ||||
Sequence: TIAPTGTVAKLAGVSEGIHPIFAKYFNRRIRFNKVSDFDQLMEMYNQGYHVEDDLFAPNTAVVTIPTKDTLLAAVEALWGPERAESLVQSAGELSLQEMLSVQATYQTCWADNAVSFTANVDPTAYS |
Sequence similarities
Belongs to the class II ribonucleoside-triphosphate reductase family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length687
- Mass (Da)76,245
- Last updated2010-03-23 v1
- Checksum0F3FE0A2B41AECD7
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
GU339467 EMBL· GenBank· DDBJ | ADB93746.1 EMBL· GenBank· DDBJ | Genomic DNA |