Lineage-specific biology revealed by a finished genome assembly of the mouse.Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L.[...], Ponting C.P.View abstractCited forNUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]StrainC57BL/6JCategorySequencesSourceUniProtKB unreviewed (TrEMBL)PubMedEurope PMCPLoS Biol. 7:E1000112-E1000112 (2009)Cited in99+99+
Direct Submission.Campello L., Esteve-Rudd J., Cuenca N., Martin-Nieto J.Cited forNUCLEOTIDE SEQUENCEStrainC57BL/6JTissueRetinaCategorySequencesSourceUniProtKB unreviewed (TrEMBL)Submission Submitted to EMBL/GenBank/DDBJ databases (DEC-2009)Cited in1
Modernizing reference genome assemblies.Church D.M., Schneider V.A., Graves T., Auger K., Cunningham F., Bouk N., Chen H.C., Agarwala R., McLaren W.M.[...], Hubbard T.Cited forNUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]StrainC57BL/6JCategorySequencesSourceUniProtKB unreviewed (TrEMBL)PubMedEurope PMCPLoS Biol 9:e1001091-e1001091 (2011)Cited in99+
No title available.EnsemblCited forIDENTIFICATIONStrainC57BL/6JSourceUniProtKB unreviewed (TrEMBL)Submission Submitted to UniProtKB (AUG-2024)Cited in99+
Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism.Kitada T., Asakawa S., Hattori N., Matsumine H., Yamamura Y., Minoshima S., Yokochi M., Mizuno Y., Shimizu N.View abstractCategorySequencesSourceMGI: 1355296PubMedEurope PMCNature 392:605-608 (1998)Cited in11Mapped to11
Inhibition of NLRP3 inflammasome ameliorates LPS-induced neuroinflammatory injury in mice via PINK1/Parkin pathway.Wang A., Zhong G., Ying M., Fang Z., Chen Y., Wang H., Wang C., Liu C., Guo Y.View abstractAnnotationInhibition of NLRP3 inflammasome ameliorates LPS-induced neuroinflammatory injury in mice via PINK1/Parkin pathway.SourceGeneRif: 50873PubMedEurope PMCNeuropharmacology 257:110063-110063 (2024)Mapped to11
Mitochondrial DNA Instability Supersedes Parkin Mutations in Driving Mitochondrial Proteomic Alterations and Functional Deficits in Polg Mutator Mice.Trease A.J., Totusek S., Lichter E.Z., Stauch K.L., Fox H.S.View abstractCategoryNamesSourceMGI: 1355296PubMedEurope PMCInt J Mol Sci 25:6441-6441 (2024)Mapped to11
The PINK1/Parkin pathway of mitophagy exerts a protective effect during prion disease.Ward A., Jessop F., Faris R., Hollister J., Shoup D., Race B., Bosio C.M., Priola S.A.View abstractCategoryNamesSourceMGI: 1355296PubMedEurope PMCPLoS One 19:e0298095-e0298095 (2024)Mapped to17
Ubiquitin Ligase Parkin Regulates the Stability of SARS-CoV-2 Main Protease and Suppresses Viral Replication.Zhou L., Liu R., Pathak H., Wang X., Jeong G.H., Kumari P., Kumar M., Yin J.View abstractAnnotationUbiquitin Ligase Parkin Regulates the Stability of SARS-CoV-2 Main Protease and Suppresses Viral Replication.CategoryNamesSourceGeneRif: 50873PubMedEurope PMCACS Infect Dis 10:879-889 (2024)Mapped to11
Parkin depletion prevents the age-related alterations in the FGF21 system and the decline in white adipose tissue thermogenic function in mice.Delgado-Angles A., Blasco-Roset A., Godoy-Nieto F.J., Cairo M., Villarroya F., Giralt M., Villarroya J.View abstractAnnotationParkin depletion prevents the age-related alterations in the FGF21 system and the decline in white adipose tissue thermogenic function in mice.CategoriesPTM / Processing, Phenotypes & VariantsSourceGeneRif: 50873, MGI: 1355296PubMedEurope PMCJ Physiol Biochem 80:41-51 (2024)Mapped to17
C-type natriuretic peptide improves maternally aged oocytes quality by inhibiting excessive PINK1/Parkin-mediated mitophagy.Zhang H., Li C., Liu Q., Li J., Wu H., Xu R., Sun Y., Cheng M., Zhao X.[...], Ma B.View abstractAnnotationC-type natriuretic peptide improves maternally aged oocytes quality by inhibiting excessive PINK1/Parkin-mediated mitophagy.CategoryFunctionSourceGeneRif: 50873PubMedEurope PMCElife 12:RP88523-RP88523 (2023)Mapped to18
Blockade of Hepatocyte PCSK9 Ameliorates Hepatic Ischemia-Reperfusion Injury by Promoting Pink1-Parkin-Mediated Mitophagy.Zhang Y., Wang Z., Jia C., Yu W., Li X., Xia N., Nie H., Wikana L.P., Chen M.[...], Pu L.View abstractAnnotationBlockade of Hepatocyte PCSK9 Ameliorates Hepatic Ischemia-Reperfusion Injury by Promoting Pink1-Parkin-Mediated Mitophagy.CategoryFunctionSourceGeneRif: 50873PubMedEurope PMCCell Mol Gastroenterol Hepatol 17:149-169 (2024)Mapped to13
PA2G4/EBP1 ubiquitination by PRKN/PARKIN promotes mitophagy protecting neuron death in cerebral ischemia.Hwang I., Kim B.S., Lee H.Y., Cho S.W., Lee S.E., Ahn J.Y.View abstractAnnotationPA2G4/EBP1 ubiquitination by PRKN/PARKIN promotes mitophagy protecting neuron death in cerebral ischemia.CategoryFunctionSourceGeneRif: 50873PubMedEurope PMCAutophagy 20:365-379 (2024)Mapped to11
Critical roles of parkin and PINK1 in coxsackievirus B3-induced viral myocarditis.Jin U., Park S.J., Lee B.G., Kim J.B., Kim S.J., Joe E.H., Woo H.G., Park S.M.View abstractAnnotationCritical roles of parkin and PINK1 in coxsackievirus B3-induced viral myocarditis.CategoryFunctionSourceGeneRif: 50873PubMedEurope PMCMicrobes Infect 25:105211-105211 (2023)Mapped to15
Longitudinal in vivo metabolic labeling reveals tissue-specific mitochondrial proteome turnover rates and proteins selectively altered by parkin deficiency.Stauch K.L., Totusek S., Trease A.J., Estrella L.D., Emanuel K., Fangmeier A., Fox H.S.View abstractCategoryNamesSourceMGI: 1355296PubMedEurope PMCSci Rep 13:11414-11414 (2023)Mapped to11
Effects of Parkin on the Mitochondrial Genome in the Heart and Brain of Mitochondrial Mutator Mice.Lichter E.Z., Trease A.J., Cooper K., Stauch K.L., Fox H.S.View abstractAnnotationEffects of Parkin on the Mitochondrial Genome in the Heart and Brain of Mitochondrial Mutator Mice.CategoryFunctionSourceGeneRif: 50873PubMedEurope PMCAdv Biol (Weinh) 7:e2300154-e2300154 (2023)Mapped to11
Autophagy prevents early proinflammatory responses and neutrophil recruitment during Mycobacterium tuberculosis infection without affecting pathogen burden in macrophages.Kinsella R.L., Kimmey J.M., Smirnov A., Woodson R., Gaggioli M.R., Chavez S.M., Kreamalmeyer D., Stallings C.L.View abstractCategoryNamesSourceMGI: 1355296PubMedEurope PMCPLoS Biol 21:e3002159-e3002159 (2023)Mapped to41
HYPERBILIRUBINEMIA AGGRAVATES RENAL ISCHEMIA REPERFUSION INJURY BY EXACERBATING PINK1-PARKIN-MEDIATED MITOPHAGY.Liao P., Wang X., Dong H., Chai D., Yue Z., Lyu L.View abstractAnnotationHYPERBILIRUBINEMIA AGGRAVATES RENAL ISCHEMIA REPERFUSION INJURY BY EXACERBATING PINK1-PARKIN-MEDIATED MITOPHAGY.CategoryPhenotypes & VariantsSourceGeneRif: 50873PubMedEurope PMCShock 60:262-271 (2023)Mapped to15
Alpha-synuclein-associated changes in PINK1-PRKN-mediated mitophagy are disease context dependent.Hou X., Chen T.H., Koga S., Bredenberg J.M., Faroqi A.H., Delenclos M., Bu G., Wszolek Z.K., Carr J.A.[...], Springer W.View abstractAnnotationAlpha-synuclein-associated changes in PINK1-PRKN-mediated mitophagy are disease context dependent.CategoryFunctionSourceGeneRif: 50873PubMedEurope PMCBrain Pathol 33:e13175-e13175 (2023)Mapped to48
Reduced mitophagy is an early feature of NAFLD and liver-specific PARKIN knockout hastens the onset of steatosis, inflammation and fibrosis.Undamatla R., Fagunloye O.G., Chen J., Edmunds L.R., Murali A., Mills A., Xie B., Pangburn M.M., Sipula I.[...], Jurczak M.J.View abstractAnnotationReduced mitophagy is an early feature of NAFLD and liver-specific PARKIN knockout hastens the onset of steatosis inflammation and fibrosis.CategoriesFunction, Phenotypes & VariantsSourceGeneRif: 50873, MGI: 1355296PubMedEurope PMCSci Rep 13:7575-7575 (2023)Mapped to15
Parkin regulates microglial NLRP3 and represses neurodegeneration in Parkinson's disease.Yan Y.Q., Zheng R., Liu Y., Ruan Y., Lin Z.H., Xue N.J., Chen Y., Zhang B.R., Pu J.L.View abstractAnnotationParkin regulates microglial NLRP3 and represses neurodegeneration in Parkinson's disease.CategoriesFunction, Phenotypes & VariantsSourceGeneRif: 50873PubMedEurope PMCAging Cell 22:e13834-e13834 (2023)Mapped to12
Mitophagy alleviates cisplatin-induced renal tubular epithelial cell ferroptosis through ROS/HO-1/GPX4 axis.Lin Q., Li S., Jin H., Cai H., Zhu X., Yang Y., Wu J., Qi C., Shao X.[...], Ni Z.View abstractCategoryNamesSourceMGI: 1355296PubMedEurope PMCInt J Biol Sci 19:1192-1210 (2023)Mapped to20
Dysfunction in parkin aggravates inflammatory bone erosion by reinforcing osteoclast activity.Kim E.Y., Kim J.E., Kim Y.E., Choi B., Sohn D.H., Park S.O., Chung Y.H., Kim Y., Robinson W.H.[...], Chang E.J.View abstractCategoryNamesSourceMGI: 1355296PubMedEurope PMCCell Biosci 13:48-48 (2023)Mapped to11
RhoA rescues cardiac senescence by regulating Parkin-mediated mitophagy.Soh J.E.C., Shimizu A., Molla M.R., Zankov D.P., Nguyen L.K.C., Khan M.R., Tesega W.W., Chen S., Tojo M.[...], Ogita H.View abstractAnnotationRhoA rescues cardiac senescence by regulating Parkin-mediated mitophagy.CategoryFunctionSourceGeneRif: 50873, MGI: 1355296PubMedEurope PMCJ Biol Chem 299:102993-102993 (2023)Mapped to20
Mitochondrial fragmentation and donut formation enhance mitochondrial secretion to promote osteogenesis.Suh J., Kim N.K., Shim W., Lee S.H., Kim H.J., Moon E., Sesaki H., Jang J.H., Kim J.E., Lee Y.S.View abstractCategoriesFunction, Subcellular LocationSourceMGI: 1355296PubMedEurope PMCCell Metab 35:345-360.e7 (2023)Mapped to66