D3HRB2 · D3HRB2_LEGLN

Function

function

Lysosomal dipeptide uniporter that selectively exports lysine, arginine or histidine-containing dipeptides with a net positive charge from the lysosome lumen into the cytosol. Could play a role in a specific type of protein O-glycosylation indirectly regulating macrophages migration and tissue invasion. Also essential for liver homeostasis.

Catalytic activity

  • L-alanyl-L-lysine(out) = L-alanyl-L-lysine(in)
  • L-alpha-aminoacyl-L-arginine(out) = L-alpha-aminoacyl-L-arginine(in)
  • L-alpha-aminoacyl-L-histidine(out) = L-alpha-aminoacyl-L-histidine(in)
  • L-alpha-aminoacyl-L-lysine(out) = L-alpha-aminoacyl-L-lysine(in)
  • L-arginyl-L-alpha-amino acid(out) = L-arginyl-L-alpha-amino acid(in)
  • L-arginyl-glycine(out) = L-arginyl-glycine(in)
  • L-aspartyl-L-lysine(out) = L-aspartyl-L-lysine(in)
  • L-histidyl-L-alpha-amino acid(out) = L-histidyl-L-alpha-amino acid(in)
  • L-histidyl-glycine(out) = L-histidyl-glycine(in)
  • L-lysyl-L-alanine(out) = L-lysyl-L-alanine(in)
  • L-lysyl-L-alpha-amino acid(out) = L-lysyl-L-alpha-amino acid(in)
  • L-lysyl-L-lysine(out) = L-lysyl-L-lysine(in)
  • L-lysyl-glycine(out) = L-lysyl-glycine(in)

GO annotations

AspectTerm
Cellular Componentlysosomal membrane
Molecular Functiontransmembrane transporter activity

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Lysosomal dipeptide transporter MFSD1
  • Alternative names
    • Major facilitator superfamily domain-containing protein 1

Gene names

    • Ordered locus names
      LLO_1087

Organism names

Accessions

  • Primary accession
    D3HRB2

Proteomes

Subcellular Location

Lysosome membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane6-33Helical
Transmembrane40-57Helical
Transmembrane63-84Helical
Transmembrane96-121Helical
Transmembrane127-149Helical
Transmembrane175-198Helical
Transmembrane218-236Helical
Transmembrane243-260Helical
Transmembrane266-287Helical
Transmembrane299-321Helical
Transmembrane341-361Helical

Keywords

Interaction

Subunit

Homodimer. Interacts with lysosomal protein GLMP (via lumenal domain); the interaction starts while both proteins are still in the endoplasmic reticulum and is required for stabilization of MFSD1 in lysosomes but has no direct effect on its targeting to lysosomes or transporter activity.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain1-366Major facilitator superfamily (MFS) profile

Sequence similarities

Belongs to the major facilitator superfamily.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    366
  • Mass (Da)
    40,177
  • Last updated
    2010-03-23 v1
  • MD5 Checksum
    4B506191008CA807D55DEAB1E94B98A0
MHEQKLAALTAGLLSSAFYYVYTTMQIPVGLLFDRYNTRILLSLNALICALGCFLFSTGHNLFILFLGRLIIGGGSAFAFVGVTRILRQHYPLRQYAFMIGLSETLGFTVTVFGMVGMGALINQISWQNFIAGAGVIGLLISTLCWKYIPANKPIISNHTQYKGHLLSMLKNKLVWINGLFVGLEFSVITVFAAMWAVPFLQLKLECSLETASILTSMVLFGAGLSCPIFGWLSMYLPQRKPLIHISCLSTAILFLFMLYLPIHSIFIMGFLLFVIGLCCGAYMLAFTIANELAPPESLSACTGFTNTLAMLSAPLLQPLIGYFLDHFKGDTNLHALNDYQLALLVIPAALILASLLSQCLPDKPS

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
FN650140
EMBL· GenBank· DDBJ
CBJ11439.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
Help