D3HKL6 · D3HKL6_LEGLN

Function

function

Lysosomal dipeptide uniporter that selectively exports lysine, arginine or histidine-containing dipeptides with a net positive charge from the lysosome lumen into the cytosol. Could play a role in a specific type of protein O-glycosylation indirectly regulating macrophages migration and tissue invasion. Also essential for liver homeostasis.

Catalytic activity

  • L-alanyl-L-lysine(out) = L-alanyl-L-lysine(in)
  • L-alpha-aminoacyl-L-arginine(out) = L-alpha-aminoacyl-L-arginine(in)
  • L-alpha-aminoacyl-L-histidine(out) = L-alpha-aminoacyl-L-histidine(in)
  • L-alpha-aminoacyl-L-lysine(out) = L-alpha-aminoacyl-L-lysine(in)
  • L-arginyl-L-alpha-amino acid(out) = L-arginyl-L-alpha-amino acid(in)
  • L-arginyl-glycine(out) = L-arginyl-glycine(in)
  • L-aspartyl-L-lysine(out) = L-aspartyl-L-lysine(in)
  • L-histidyl-L-alpha-amino acid(out) = L-histidyl-L-alpha-amino acid(in)
  • L-histidyl-glycine(out) = L-histidyl-glycine(in)
  • L-lysyl-L-alanine(out) = L-lysyl-L-alanine(in)
  • L-lysyl-L-alpha-amino acid(out) = L-lysyl-L-alpha-amino acid(in)
  • L-lysyl-L-lysine(out) = L-lysyl-L-lysine(in)
  • L-lysyl-glycine(out) = L-lysyl-glycine(in)

GO annotations

AspectTerm
Cellular Componentlysosomal membrane
Molecular Functiontransmembrane transporter activity

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Lysosomal dipeptide transporter MFSD1
  • Alternative names
    • Major facilitator superfamily domain-containing protein 1

Gene names

    • Ordered locus names
      LLO_2560

Organism names

Accessions

  • Primary accession
    D3HKL6

Proteomes

Subcellular Location

Lysosome membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane7-25Helical
Transmembrane45-62Helical
Transmembrane82-105Helical
Transmembrane111-132Helical
Transmembrane167-190Helical
Transmembrane222-240Helical
Transmembrane260-280Helical
Transmembrane292-310Helical
Transmembrane316-337Helical
Transmembrane349-372Helical
Transmembrane404-423Helical

Keywords

Interaction

Subunit

Homodimer. Interacts with lysosomal protein GLMP (via lumenal domain); the interaction starts while both proteins are still in the endoplasmic reticulum and is required for stabilization of MFSD1 in lysosomes but has no direct effect on its targeting to lysosomes or transporter activity.

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain13-428Major facilitator superfamily (MFS) profile

Sequence similarities

Belongs to the major facilitator superfamily.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    432
  • Mass (Da)
    47,379
  • Last updated
    2010-03-23 v1
  • MD5 Checksum
    05BA423A8DD4AF9FFF181EDF41F217A7
MLSENRRNYALIGWLICGLGAMFYSYEYLLRIAPSAMETALREHFNLSATGFGNISSVYYYAYVPMQLPVGIMMDRYGPRRLLTFACLICVIGTFLFTGTTSFWVAAAGRFLVGLGSAFAFVGVLKLATIWLPENKLAMVSGITSALGTVGAMLGDNFLEIFVHRLGWIKTLHMTAFFGIVLTFILWLGIHDKKGRYRQSGTVSSFKKGMIDLGIIARNKQIWVNGLFGCLVYLPTTVFAELWGIPYLRHAHGLSAHGAGLANSLLFLGFTLGAPLMGYFSDRIARRKLPMLLGSSVATVLMVVILYFPGLSESNVQILMFFLGLFYSAQAIVFAVGRELSPGEAAGTAMALTNMIVMLGGMLLQPLVGYLLDFSYSLRSGASLTTALAVENVHKLYNMTDYRIALAFIPIGMCIAALLTFFLKETHAHAPK

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
FN650140
EMBL· GenBank· DDBJ
CBJ12982.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

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