D3E3N9 · EF2_METRM

Function

function

Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.

Features

Showing features for binding site.

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TypeIDPosition(s)Description
Binding site28-35GTP (UniProtKB | ChEBI)
Binding site94-98GTP (UniProtKB | ChEBI)
Binding site148-151GTP (UniProtKB | ChEBI)

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentcytosol
Cellular Componentribonucleoprotein complex
Molecular FunctionGTP binding
Molecular FunctionGTPase activity
Molecular Functiontranslation elongation factor activity

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Elongation factor 2
  • Short names
    EF-2

Gene names

    • Name
      fusA
    • Ordered locus names
      mru_1300

Organism names

Accessions

  • Primary accession
    D3E3N9

Proteomes

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for chain, modified residue.

TypeIDPosition(s)Description
ChainPRO_00004089611-731Elongation factor 2
Modified residue598Diphthamide

Interaction

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain19-234tr-type G

Sequence similarities

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    731
  • Mass (Da)
    80,730
  • Last updated
    2010-03-23 v1
  • Checksum
    B39176940F169A92
MSRRDKMIAKIKELMYKPEYIRNIGICAHIDHGKTTLSDNLLAGAGLISEDLAGEALGMDTKKDEQERGITIDAANASMVQEYEGEQYLINLIDTPGHVDFGGDVTRAMRAVDGAVVVVCAVDGVMPQTETVLKQALRENVKPVLFINKVDRLINELKLGPEELLKQLTSIIVEVNALIKSLAPKDKKNEWMVNVEEGSVAFGSAFKNWAINIPKMQETKFTFKDIIDYCNEGKEDELKQLLPLTEVLLNMVVKHLPSPNVAQVYRVPKIWDGDIESEVGQTMIKMSPDGPLAGMITNVAVDKHAGIVATCRIYGGTLEKSSEIYLVGSHGKARVQQAGIFMGAETIDTGKVPVGNIAYLTGVKGASAGETICSADCIIDEFEPIDHISEPVVTVAVEAKNTKDLPKLIEVLRQVSKEDPTIKVEINETTGEQLISGMGELHLEVVTNRIINDKKLEILVSEPIIVYKESVLGHSPVIEGKSPNKHNRFYIDVQPLDKPLYDALIEGDLKEGRIKTKETAQDFIELGMDKEEARRVWDVYNRSMFINMTRGIQYLDEVKELLLEGFEAALKDGPLANEEAVGLKFILSDAKLHEDAVHRGPAQVLPAIKKAIYASIMSANPCLLEPIQKVFISAPLEYMGNCNKDIQNRRGRIIGQETKGVIAEMDFEVPIAKMFGFAGDIRSATGGKGDFSTEMKGFETLPIYLQDDIVRQIRTRKGLSPEPYGPEHYSA

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP001719
EMBL· GenBank· DDBJ
ADC47150.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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