D3E3M2 · ARFB_METRM

Function

function

Catalyzes the hydrolysis of the formamide of 2-amino-5-formylamino-6-ribosylamino-4(3H)-pyrimidinone 5'-monophosphate (FAPy) to form 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate (APy).

Catalytic activity

Cofactor

Protein has several cofactor binding sites:
Fe2+ (UniProtKB | Rhea| CHEBI:29033 )

Note: Requires one Fe2+ ion for activity.
Fe2+ (UniProtKB | Rhea| CHEBI:29033 )

Zn2+ (UniProtKB | Rhea| CHEBI:29105 )

Note: Requires an additional second metal ion that could be Fe2+ or Zn2+.

Pathway

Cofactor biosynthesis; coenzyme F420 biosynthesis.
Cofactor biosynthesis; riboflavin biosynthesis.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site29Fe cation 1 (UniProtKB | ChEBI)
Binding site31Fe cation 2 (UniProtKB | ChEBI)
Binding site40Fe cation 1 (UniProtKB | ChEBI)
Binding site40Fe cation 2 (UniProtKB | ChEBI)
Binding site109Fe cation 1 (UniProtKB | ChEBI)

GO annotations

AspectTerm
Molecular Function2-amino-5-formylamino-6-(5-phosphoribosylamino)pyrimidin-4(3H)-one formate-lyase activity
Molecular Functionferrous iron binding
Biological ProcessF420-0 metabolic process
Biological Processriboflavin biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    2-amino-5-formylamino-6-ribosylaminopyrimidin-4(3H)-one 5'-monophosphate deformylase
  • EC number
  • Short names
    FAPy deformylase
  • Alternative names
    • Formamide hydrolase

Gene names

    • Name
      arfB
    • Ordered locus names
      mru_1283

Organism names

Accessions

  • Primary accession
    D3E3M2

Proteomes

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00004069181-2342-amino-5-formylamino-6-ribosylaminopyrimidin-4(3H)-one 5'-monophosphate deformylase

Interaction

Subunit

Homodimer.

Protein-protein interaction databases

Family & Domains

Sequence similarities

Belongs to the creatininase superfamily. FAPy deformylase family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    234
  • Mass (Da)
    25,457
  • Last updated
    2010-03-23 v1
  • Checksum
    86D2559AF142AED3
MVELRVNAGNVKNPNVHKIGIIALGSHLENHGPALPIDTDAKIASHIAFQASLESGAKFLGVIYPAHELKEINHGIHVSLEDLTDEIVKVLKSAKKFLRISSVIIVNGHGGNLPIVTTLYDIEERTGLLITLNSKIIESEGPHGGSGELSMAKALGIIDESQVENQTNLEEYGEVGLYMFGEARRNDPNIEEGALDVEENGVYVDDVYGQELLKLAINSVLLDVEKQLDSHYGY

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP001719
EMBL· GenBank· DDBJ
ADC47133.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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