D3E2P9 · D3E2P9_METRM
- ProteinMethionine--tRNA ligase
- GenemetG
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids691 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.
Catalytic activity
- tRNA(Met) + L-methionine + ATP = L-methionyl-tRNA(Met) + AMP + diphosphate
Cofactor
Note: Binds 1 zinc ion per subunit.
Features
Showing features for binding site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 143 | Zn2+ (UniProtKB | ChEBI) | |||
Binding site | 146 | Zn2+ (UniProtKB | ChEBI) | |||
Binding site | 155 | Zn2+ (UniProtKB | ChEBI) | |||
Binding site | 158 | Zn2+ (UniProtKB | ChEBI) | |||
Binding site | 328 | ATP (UniProtKB | ChEBI) | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | aminoacyl-tRNA synthetase multienzyme complex | |
Cellular Component | cytosol | |
Molecular Function | ATP binding | |
Molecular Function | metal ion binding | |
Molecular Function | methionine-tRNA ligase activity | |
Molecular Function | tRNA binding | |
Biological Process | methionyl-tRNA aminoacylation |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameMethionine--tRNA ligase
- EC number
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageArchaea > Euryarchaeota > Methanomada group > Methanobacteria > Methanobacteriales > Methanobacteriaceae > Methanobrevibacter
Accessions
- Primary accessionD3E2P9
Proteomes
Subcellular Location
Interaction
Structure
Family & Domains
Features
Showing features for motif, region, domain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Motif | 11-21 | 'HIGH' region | |||
Motif | 325-329 | 'KMSKS' region | |||
Region | 549-584 | Disordered | |||
Domain | 595-691 | TRNA-binding | |||
Sequence similarities
Belongs to the class-I aminoacyl-tRNA synthetase family. MetG type 1 subfamily.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length691
- Mass (Da)78,921
- Last updated2010-03-23 v1
- MD5 ChecksumE986C26D3555AB30A90A48D6C365D02F
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
CP001719 EMBL· GenBank· DDBJ | ADC46810.1 EMBL· GenBank· DDBJ | Genomic DNA |