D2Y3G0 · D2Y3G0_CYPCA

Function

function

Receptor for pituitary gland growth hormone (GH1) involved in regulating postnatal body growth. On ligand binding, couples to the JAK2/STAT5 pathway.
The soluble form (GHBP) acts as a reservoir of growth hormone in plasma and may be a modulator/inhibitor of GH signaling.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentexternal side of plasma membrane
Molecular Functioncytokine receptor activity

Keywords

  • Molecular function

Names & Taxonomy

Protein names

  • Submitted names
    • Growth hormone receptor type 2b

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Actinopterygii > Neopterygii > Teleostei > Ostariophysi > Cypriniformes > Cyprinidae > Cyprininae > Cyprinus

Accessions

  • Primary accession
    D2Y3G0

Subcellular Location

Membrane
; Single-pass type I membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane239-261Helical

Keywords

  • Cellular component

PTM/Processing

Features

Showing features for signal, chain.

Type
IDPosition(s)Description
Signal1-19
ChainPRO_500303894920-569

Family & Domains

Features

Showing features for domain, compositional bias, region.

Type
IDPosition(s)Description
Domain131-235Fibronectin type-III
Compositional bias336-355Polar residues
Region336-384Disordered
Compositional bias356-380Basic and acidic residues
Region470-489Disordered
Region539-569Disordered

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    569
  • Mass (Da)
    63,651
  • Last updated
    2010-03-02 v1
  • Checksum
    02BAA497E1527912
METTLFIFILLTCAVATQSVPPTIQGQTSTLPHLTGCFSRELMTFRCQWETGSLQNHTEPEDLSLFYMLEKDSKKWMECPSYSSIRKNECYFDSSNTIIWFPYVVQLRSRSLDVVYDEMSFNVEDIVFPDPPVGLNWTLLSMGSTGLINDVVVSWDPPPSAAENVKTGWIQLVYETQYREKGSDHWNSLDNGKDTQAYIYALHSNIEYEVRVRSKMRGYNFGVFSESIFILIPNKESRIPITAVLVFAAVGIAIILMLVVVSRQQKLMVIFLPPIPGPKIKGIDPVLLLKGQLTEFTSILGAHPSLWPELYSNDPWVEFIEVDIDEPHESQEELLITDSPVSDSPQMSSSFRDDDSGRASCCDPDLSDHDQADLHHPSTSSHDGFHALARAQSGPQQPAAFSSQDTTWSNSLYSQVIDVTHHGGVVLSPEEKETMALKDKNHNKGKEIQQLVVIPDERGYTSEFVASTISTHHNKPNPPTDQLQSQEQHGAFRDLQKLSTETVTSTQSTAFPIPANPTSPEYTMVDGVDWKNSLLLKPNTPTAPQKAAVKTLPTPEEYLTPDLLDNVTP

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias336-355Polar residues
Compositional bias356-380Basic and acidic residues

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
GU296685
EMBL· GenBank· DDBJ
ADB66162.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
Help