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D2UDR7 · D2UDR7_XANAP

Function

function

Endoribonuclease that plays a central role in RNA processing and decay. Required for the maturation of 5S and 16S rRNAs and the majority of tRNAs. Also involved in the degradation of most mRNAs.

Catalytic activity

  • Endonucleolytic cleavage of single-stranded RNA in A- and U-rich regions.
    EC:3.1.26.12 (UniProtKB | ENZYME | Rhea)

Cofactor

Protein has several cofactor binding sites:
Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Note: Binds 1 Mg2+ ion per subunit.
Zn2+ (UniProtKB | Rhea| CHEBI:29105 )

Note: Binds 2 Zn2+ ions per homotetramer.

Features

Showing features for binding site.

111121002003004005006007008009001,0001,100
TypeIDPosition(s)Description
Binding site301Mg2+ (UniProtKB | ChEBI); catalytic
Binding site344Mg2+ (UniProtKB | ChEBI); catalytic
Binding site402Zn2+ (UniProtKB | ChEBI); ligand shared between dimeric partners
Binding site405Zn2+ (UniProtKB | ChEBI); ligand shared between dimeric partners

GO annotations

AspectTerm
Cellular Componentcytoplasm
Cellular Componentcytoplasmic side of plasma membrane
Molecular Functionmagnesium ion binding
Molecular Functionribonuclease E activity
Molecular FunctionRNA endonuclease activity
Molecular FunctionrRNA binding
Molecular FunctiontRNA binding
Molecular Functionzinc ion binding
Biological ProcessmRNA catabolic process
Biological ProcessrRNA processing
Biological ProcesstRNA processing

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Ribonuclease E
  • EC number
  • Short names
    RNase E

Gene names

    • Name
      rne
    • Ordered locus names
      XALc_1617

Organism names

Accessions

  • Primary accession
    D2UDR7

Proteomes

Subcellular Location

Cytoplasm
Cell inner membrane
; Peripheral membrane protein

Keywords

Interaction

Subunit

Component of the RNA degradosome, which is a multiprotein complex involved in RNA processing and mRNA degradation. Within the RNA degradosome, RNase E assembles into a homotetramer formed by a dimer of dimers.

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain, region, compositional bias.

Type
IDPosition(s)Description
Domain39-118S1 motif
Region402-405Required for zinc-mediated homotetramerization and catalytic activity
Region526-557Disordered
Compositional bias578-596Polar residues
Region578-710Disordered
Compositional bias597-612Basic and acidic residues
Compositional bias628-669Polar residues
Compositional bias677-696Polar residues
Region752-894Disordered
Compositional bias764-778Polar residues
Compositional bias867-885Basic and acidic residues
Region1026-1051Disordered
Region1063-1112Disordered
Compositional bias1072-1094Polar residues
Compositional bias1096-1112Basic and acidic residues

Sequence similarities

Belongs to the RNase E/G family. RNase E subfamily.
Belongs to the RNase E/G family. RNase G subfamily.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    1,112
  • Mass (Da)
    120,522
  • Last updated
    2010-03-02 v1
  • MD5 Checksum
    15DE52AF2BD868EC56AACC76582E66EB
MKRMLINATQAEELRVAIVDGQTLYDIDIEQPSKEQKKSNIYKGRITRLEPSLEAAFVEYGGERHGFLPLKEISRDYFQAGVDHNKATIRELLREGQEVVVQVDKEERGNKGAALTTFISLAGRYMVLMPNSPSAGGVSRRIEGEDRAALKEALDKLTIPDDMGVIIRTAGVGRDAEELQWDLEYLLQVWKSIAEAALAKPAPFLIYQESRLIIRALRDYLRADIGEILVDTVEMYGDAKEFMQQVMPQSLRKLKHYTDDIPLFNRFQIESQIEAAYERSVRLPSGGSIVVDQTEALTAVDVNSSRATKGSDIEDTAFQTNLEAAEEVARQLRLRDLGGLVVIDFIDMASNKHQREVENRLQNALKYDRARVQIGRISRFGLLEMSRQRLRPSLGESSQIVCPRCDGHGRMRSVESLSLSIIRVAEEHAMKENTGQVLVQAPVEIANYLLNEKRRALSEIEKRHDAPIVIVADEQLQTPHYEVTRLRENELGEESTKPSYQRGTPRKLPVHALTKAQLNIPPAPAVTHVQHSQPAPLRETAEATTAAPALMPPPPSVTATPAIGIVGWLKRIFGASENQAQAPTAPEPAQRQRPQDGNRNRNGDRHDRNARRNGGQGGNAGRGNGGGNGRRTGNNGAVQSGGQQNPSPKLPRNEQTSQQAKQQQTPKPPKQQQQNPPRQPKPQQEASQAAVQNEKSQRQARTDENAKQVASVPVAPVALAQDAATFAPPVAVGDIPQRQEAQAVTSLAPLVAATPHANGDEHESVLETGQSVLASENSDGDDVNGEAGGRRRRGRRGGRRRRRGNGETGVIGEGEVAGLDDIDLNAADNDGETTPAPNRSQPEFDFDDDVTVDSTNVKPQSPFKETPAPQEKREPQPRRERPAIDTQAATHQTATASSAFVDNAPPQGVTLTQAIVAAPPPTHETAEGIAQLTTAMGTADHAASDASGAHTDAASATLIVDKTTPTMRMESAAEQLPAIAPTTASDAAPTAPVKMIEQPKAADTPAPAAGVVATPMRGADPFGMTAPASAATRETATNASQRHDDPAPVKPTYAPVQTTLLDVLKPNTHETVPRHNVGTTSTPVAGTTPVVVQPSRKTEGEDDENKEQQDRS

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias578-596Polar residues
Compositional bias597-612Basic and acidic residues
Compositional bias628-669Polar residues
Compositional bias677-696Polar residues
Compositional bias764-778Polar residues
Compositional bias867-885Basic and acidic residues
Compositional bias1072-1094Polar residues
Compositional bias1096-1112Basic and acidic residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
FP565176
EMBL· GenBank· DDBJ
CBA16116.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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