D2THQ7 · D2THQ7_CITRI

Function

function

Catalyzes the formation of a hydroxyacyl-CoA by addition of water on enoyl-CoA. Also exhibits 3-hydroxyacyl-CoA epimerase and 3-hydroxyacyl-CoA dehydrogenase activities.

Catalytic activity

Pathway

Lipid metabolism; fatty acid beta-oxidation.

Features

Showing features for site.

TypeIDPosition(s)Description
Site118Important for catalytic activity
Site140Important for catalytic activity

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular Function3-hydroxyacyl-CoA dehydrogenase activity
Molecular Function3-hydroxybutyryl-CoA epimerase activity
Molecular Functionenoyl-CoA hydratase activity
Molecular FunctionNAD+ binding
Biological Processfatty acid beta-oxidation

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Fatty acid oxidation complex subunit alpha

Including 2 domains:

  • Recommended name
    Enoyl-CoA hydratase/3-hydroxybutyryl-CoA epimerase
  • EC number
  • Recommended name
    3-hydroxyacyl-CoA dehydrogenase
  • EC number

Gene names

    • Name
      fadJ
    • Ordered locus names
      ROD_27451

Organism names

Accessions

  • Primary accession
    D2THQ7

Proteomes

Subcellular Location

Keywords

Interaction

Subunit

Heterotetramer of two alpha chains (FadJ) and two beta chains (FadI).

Protein-protein interaction databases

Family & Domains

Features

Showing features for region, domain.

TypeIDPosition(s)Description
Region1-190Enoyl-CoA hydratase
Region306-7143-hydroxyacyl-CoA dehydrogenase
Domain311-4893-hydroxyacyl-CoA dehydrogenase NAD binding
Domain492-5863-hydroxyacyl-CoA dehydrogenase C-terminal
Domain619-7043-hydroxyacyl-CoA dehydrogenase C-terminal

Sequence similarities

In the N-terminal section; belongs to the enoyl-CoA hydratase/isomerase family.
In the central section; belongs to the 3-hydroxyacyl-CoA dehydrogenase family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    714
  • Mass (Da)
    76,934
  • Last updated
    2010-03-02 v1
  • Checksum
    FF4CC791D02D5754
MDMRSAFTLNLRPDNVAVIAIDVPDEKMNTLKAEFASQVRAILKQLRDNRELRGVVFISAKADNFIAGADINMIGNCASAEEAQALARQGQQLMAEINALSVPVVAAIHGPCLGGGLELALACHARICTDDKKTVLGLPEVQLGLLPGSGGTQRLPRLVGVSTALDMILSGKQLRAKQALKIGLVDEVVPRSILLEAAVERAKQDRTEHRPLPVRERVLAGPLGRALLFRMAGKKTQHKTHGNYPAAERILQVIETGLAQGVSSGYEAEARAFGELAMSPQSRALRAIFFASTDVKKDPGSAESAGPLASVGVLGGGLMGGGIAYVTACKGGLPVRIKDIDAKGINHALKYSWDQLETKVRRRHIKASERDKQLALISGATDYRGFSRRDVIIEAVFEDLALKQRMVAEVEQNCAPHTIFASNTSSLPISDIAANAARPEQVIGLHFFSPVEKMPLVEVIPHASTSGKTIATTVKLAKKQGKTPIVVQDKAGFYVNRILAPYINEAIRMLTEGERVEQIDDALVKFGFPVGPIQLLDEVGIDTGTKIIPVLEAAYGERFSAPANVVTSILNDDRKGRKNGRGFYLYGAKGRKSKKQADPAIYTLIGASGQGRLSARQMAERCVMLMLNEAARCFDEQVIRSARDGDIGAVFGIGFPPFLGGPFRYMDSLGAGEVVAVLQRLASQYGPRFAPCEALLQMAERGESFWKTDATDPK

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
FN543502
EMBL· GenBank· DDBJ
CBG89488.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

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