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D2RLU3 · D2RLU3_ACIFV

Function

function

Catalyzes the hydrolysis of UDP-3-O-myristoyl-N-acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis.
Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs.

Catalytic activity

Cofactor

Zn2+ (UniProtKB | Rhea| CHEBI:29105 )

Pathway

Glycolipid biosynthesis; lipid IV(A) biosynthesis; lipid IV(A) from (3R)-3-hydroxytetradecanoyl-[acyl-carrier-protein] and UDP-N-acetyl-alpha-D-glucosamine: step 2/6.

Features

Showing features for binding site, active site.

Type
IDPosition(s)Description
Binding site80Zn2+ (UniProtKB | ChEBI)
Binding site235Zn2+ (UniProtKB | ChEBI)
Binding site239Zn2+ (UniProtKB | ChEBI)
Active site261Proton donor
Active site349

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular Function(3R)-hydroxyacyl-[acyl-carrier-protein] dehydratase activity
Molecular Functionmetal ion binding
Molecular FunctionUDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
Molecular FunctionUDP-3-O-acyl-N-acetylglucosamine deacetylase activity
Biological Processfatty acid biosynthetic process
Biological Processlipid A biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Multifunctional fusion protein

Including 2 domains:

  • Recommended name
    3-hydroxyacyl-[acyl-carrier-protein] dehydratase FabZ
  • EC number
  • Alternative names
    • (3R)-hydroxymyristoyl-[acyl-carrier-protein] dehydratase
    • Beta-hydroxyacyl-ACP dehydratase
      ((3R)-hydroxymyristoyl-ACP dehydrase
      )
  • Recommended name
    UDP-3-O-acyl-N-acetylglucosamine deacetylase
  • EC number
  • Short names
    UDP-3-O-acyl-GlcNAc deacetylase
  • Alternative names
    • UDP-3-O-[R-3-hydroxymyristoyl]-N-acetylglucosamine deacetylase

Gene names

    • Name
      fabZ
    • Synonyms
      lpxC
    • Ordered locus names
      Acfer_1689

Organism names

Accessions

  • Primary accession
    D2RLU3

Proteomes

Subcellular Location

Keywords

Interaction

Protein-protein interaction databases

Family & Domains

Sequence similarities

Belongs to the LpxC family.
Belongs to the thioester dehydratase family. FabZ subfamily.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    445
  • Mass (Da)
    49,213
  • Last updated
    2010-03-02 v1
  • MD5 Checksum
    DC7734674C64B9C9FF0BBAD2E55F5FBA
MTSEKQHTLKQAASCDGIGLHSGKLVEMTLRPAPVDTGIVFIRTDMEGRPQVHAVAANITATTRATTLTENGASVTTIEHLMAALAILKIDNCYVEMSSAEPPVGDGSAQAFIDQILKAGIAEQDAERQVYHVDRAFSHYDGDRSIVVLPYEGFRITFTSINPHPLLGTQVMDVEDKGENFLKEVAAARTVAFEDEIAQLQKMGLGLGGTLENVVVFGKDKILSIPRFPDELIRHKILDVIGDMYLLGPIHAHIICMKSGHAFNDNVSRQIDEYRRLHEYQPRHTPVPGKEKKEVRSKDMITLDIQEIQKILPHRYPMLLVDRIIELEPMKRAVGIKNITMNEPQFIGHFPGNPIMPGVLLIEAMAQVGGVTLLYPEENRGKIAVFGKIDKVRFRRPIKPGDQLVTTAIITKIKGNMGVAHCEGTVDGEPACEGDFFFALAENKQ

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP001859
EMBL· GenBank· DDBJ
ADB48045.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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