D2QCW2 · D2QCW2_SPILD

Function

function

Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.

Catalytic activity

Pathway

Cofactor biosynthesis; pyridoxine 5'-phosphate biosynthesis; pyridoxine 5'-phosphate from D-erythrose 4-phosphate: step 5/5.

Features

Showing features for binding site, active site, site.

Type
IDPosition(s)Description
Binding site73-amino-2-oxopropyl phosphate (UniProtKB | ChEBI)
Binding site183-amino-2-oxopropyl phosphate (UniProtKB | ChEBI)
Active site43Proton acceptor
Binding site451-deoxy-D-xylulose 5-phosphate (UniProtKB | ChEBI)
Binding site501-deoxy-D-xylulose 5-phosphate (UniProtKB | ChEBI)
Active site70Proton acceptor
Binding site1001-deoxy-D-xylulose 5-phosphate (UniProtKB | ChEBI)
Site151Transition state stabilizer
Active site190Proton donor
Binding site1913-amino-2-oxopropyl phosphate (UniProtKB | ChEBI)
Binding site213-2143-amino-2-oxopropyl phosphate (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytosol
Molecular Functionpyridoxine 5'-phosphate synthase activity
Biological Processpyridoxine biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Pyridoxine 5'-phosphate synthase
  • EC number
  • Short names
    PNP synthase

Gene names

    • Name
      pdxJ
    • Ordered locus names
      Slin_4990

Organism names

Accessions

  • Primary accession
    D2QCW2

Proteomes

Subcellular Location

Keywords

Interaction

Subunit

Homooctamer; tetramer of dimers.

Protein-protein interaction databases

Family & Domains

Sequence similarities

Belongs to the PNP synthase family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    245
  • Mass (Da)
    27,218
  • Last updated
    2010-03-02 v1
  • Checksum
    3A68D81A83CBA769
MTRLSVNINKIATIRNARGGNNPDLVKVALDCERFGAQGITVHPRPDERHIRYQDVLDLHEVVTTEFNIEGNPDERFIELVKRVKPAQVTLVPDAVDAITSNAGWDTIRHADHLRKLVDTFKADGIRVSIFVDADERMVEGAKAVGTDRIELYTEPYAAHYAENREAAVAPFVRAAQRANQLGLGLNAGHDLSLENLRFFDEQVPGLEEVSIGHALVCDALYFGLENTIQMYLRCLDRTGGPAGF

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP001769
EMBL· GenBank· DDBJ
ADB40968.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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