D2QB22 · D2QB22_BIFDB
- ProteinDeoxyuridine 5'-triphosphate nucleotidohydrolase
- Genedut
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids158 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.
Catalytic activity
- dUTP + H2O = dUMP + diphosphate + H+
Cofactor
Pathway
Pyrimidine metabolism; dUMP biosynthesis; dUMP from dCTP (dUTP route): step 2/2.
Features
Showing features for binding site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 75-77 | substrate | ||||
Sequence: RSG | ||||||
Binding site | 88 | substrate | ||||
Sequence: N | ||||||
Binding site | 92-94 | substrate | ||||
Sequence: TID |
GO annotations
Aspect | Term | |
---|---|---|
Molecular Function | dUTP diphosphatase activity | |
Molecular Function | magnesium ion binding | |
Biological Process | dUMP biosynthetic process | |
Biological Process | dUTP catabolic process |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameDeoxyuridine 5'-triphosphate nucleotidohydrolase
- EC number
- Short namesdUTPase
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageBacteria > Actinomycetota > Actinomycetes > Bifidobacteriales > Bifidobacteriaceae > Bifidobacterium
Accessions
- Primary accessionD2QB22
Proteomes
Interaction
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 30-154 | dUTPase-like | ||||
Sequence: YAHAGDAGADLKTTEEVTLEPFQRALVPTGVAIALPAGYVALVHPRSGLAVKRGVTVLNAPGTIDAGYRGEIKVPLINLDPEHTVTFQPGDRIAQLVIQRYVEARFVPAASLPGSDRAERGFGST |
Sequence similarities
Belongs to the dUTPase family.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length158
- Mass (Da)16,868
- Last updated2010-03-02 v1
- ChecksumE726042A352C5357
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
CP001750 EMBL· GenBank· DDBJ | ADB10008.1 EMBL· GenBank· DDBJ | Genomic DNA |