D2NSJ6 · D2NSJ6_ROTMD
- ProteinPyruvate dehydrogenase E1 component
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids910 (go to sequence)
- Protein existencePredicted
- Annotation score2/5
Function
function
Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2.
Catalytic activity
- N6-[(R)-lipoyl]-L-lysyl-[dihydrolipoyllysine-residue acetyltransferase] + pyruvate + H+ = N6-[(R)-S8-acetyldihydrolipoyl]-L-lysyl-[dihydrolipoyllysine-residue acetyltransferase] + CO2
Cofactor
Protein has several cofactor binding sites:
Features
Showing features for binding site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 243 | Mg2+ (UniProtKB | ChEBI) | |||
Binding site | 273 | Mg2+ (UniProtKB | ChEBI) | |||
Binding site | 275 | Mg2+ (UniProtKB | ChEBI) | |||
GO annotations
Aspect | Term | |
---|---|---|
Molecular Function | magnesium ion binding | |
Molecular Function | pyruvate dehydrogenase (acetyl-transferring) activity |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended namePyruvate dehydrogenase E1 component
- EC number
Gene names
Organism names
- Strain
- Taxonomic lineageBacteria > Actinomycetota > Actinomycetes > Micrococcales > Micrococcaceae > Rothia
Accessions
- Primary accessionD2NSJ6
Proteomes
Interaction
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Domain | 148-314 | Transketolase N-terminal | |||
Domain | 493-717 | Pyruvate dehydrogenase E1 component middle | |||
Domain | 732-866 | Transketolase-like C-terminal | |||
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length910
- Mass (Da)101,150
- Last updated2010-03-02 v1
- MD5 ChecksumE8319094A455676F116F500D0BBBBC9C
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AP011540 EMBL· GenBank· DDBJ | BAI64622.1 EMBL· GenBank· DDBJ | Genomic DNA |