D2NQS1 · D2NQS1_ROTMD

Function

function

Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate.

Miscellaneous

The reaction proceeds by a bi uni uni bi ping pong mechanism.

Catalytic activity

Pathway

Cofactor biosynthesis; (R)-pantothenate biosynthesis; (R)-pantothenate from (R)-pantoate and beta-alanine: step 1/1.

Features

Showing features for binding site, active site.

Type
IDPosition(s)Description
Binding site59-66ATP (UniProtKB | ChEBI)
Active site66Proton donor
Binding site90(R)-pantoate (UniProtKB | ChEBI)
Binding site90beta-alanine (UniProtKB | ChEBI)
Binding site183-186ATP (UniProtKB | ChEBI)
Binding site189(R)-pantoate (UniProtKB | ChEBI)
Binding site212ATP (UniProtKB | ChEBI)
Binding site220-223ATP (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytosol
Molecular FunctionATP binding
Molecular Functionpantoate-beta-alanine ligase activity
Biological Processpantothenate biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Pantothenate synthetase
  • EC number
  • Short names
    PS
  • Alternative names
    • Pantoate--beta-alanine ligase
    • Pantoate-activating enzyme

Gene names

    • Name
      panC
    • Ordered locus names
      RMDY18_01650

Organism names

Accessions

  • Primary accession
    D2NQS1

Proteomes

Subcellular Location

Keywords

Interaction

Subunit

Homodimer.

Protein-protein interaction databases

Family & Domains

Sequence similarities

Belongs to the pantothenate synthetase family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    315
  • Mass (Da)
    34,668
  • Last updated
    2010-03-02 v1
  • MD5 Checksum
    F0157EE23B803D99E844C5065D1025E8
MTETSMPRVVTTIADFRTAITESLAAAQEELDRTARQEAEQNGTAVQYTNASLGYVPTMGALHDGHATLLRRAAEQNDVVVASIFVNPLQFGPGEDYEAYPRTLEADAALAGAAGVDIIFTPEVEEMYPDGDPLIRISSGELGTKFEGATRPGHFDGVLAVVNKFFNIIRPVAGNHPVNAYFGQKDAQQYILIQRMVHDFNHDVTMRPVAIVRDDNGLALSSRNSYLSDEERESALVLSRTLAMLRENSLNRGFHEIDLDGARERINSTPGVRLDYLELVDPMTFGEPTEESERVLALVAAFVGPTRLIDNMDLR

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AP011540
EMBL· GenBank· DDBJ
BAI63997.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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