D2KMR8 · D2KMR8_LEIDO
- ProteinSubtilisin
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids1744 (go to sequence)
- Protein existenceInferred from homology
- Annotation score2/5
Function
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | membrane | |
Molecular Function | serine-type endopeptidase activity | |
Biological Process | proteolysis |
Keywords
- Molecular function
Names & Taxonomy
Protein names
- Submitted names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Discoba > Euglenozoa > Kinetoplastea > Metakinetoplastina > Trypanosomatida > Trypanosomatidae > Leishmaniinae > Leishmania
Accessions
- Primary accessionD2KMR8
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 1709-1732 | Helical | ||||
Sequence: WLQHPMVLGQLMVSAAVVMSVWLC |
Keywords
- Cellular component
PTM/Processing
Features
Showing features for signal, chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Signal | 1-28 | |||||
Sequence: MEAVVALRLLTIHILAALLLVLPSFPLA | ||||||
Chain | PRO_5003033688 | 29-1744 | ||||
Sequence: EGPWPLSVQAAHRSTDAHAEGPSIHPRKYYLGKYGAHCIRNLTEFVASEDAAERLACFSGRGVRVALLETGLCAGIAERSRNSVTCTSVVPGVACEDAGCAHGTRSVSVLAGQLTVSAPLPREPLEETAWRNRETHLALADQYIGLAPDSTVRVLRIFDRQGRTNRRHLARALDLLLREAEDGEAGRLHSAWNTSSAHIRRRDETVDVISLSYGSKDYHSSPQVQDRLYRLMHEHGVIVVAAAGNDGARFGSVRSPADMPGVLAVGALRMEWHGRSAQTTQASRTLGDLASSLAAGGGHKSVAHFSGRGPTTWELPFGAGRAKPDLVALGQHVWAVQGVSAAAFSAAAPRARSASPALQLRSASGTSIAAPIVAGVVALCLEAAWSSTSAVALAQNMTGGGSFLDVRQNRLARVSDSLRVREVILRTAVPLGEAAASLPPWPHSAPTTPLHSDSSSTASEAHPRRVLAGVPLLKLYAGYLRLSRVSILSQGAGEVQPLRALHAIVAKAAASSAIDAPEALRNCASFAIPTCVRIGYRIPRCSNSNSSSSSSSGDMSTPQSCQPPHDPDGKAHGDSPLPGRSGMSLDAPPAAYWWPFSDQAVYPGATPVLLNISLHLCPPSSPAAADQGTRDAAAAASGKGARRGSTTHIHVTHVITKVSGHVRAREGHPSRNSSHQCDACPLLFEGAKSRHRAGSTSPTRLLNLTARSASPRASCSDGEVAGEGATVMGPRHTQTAVCSSVKRWSTQQRWIHHLLRVATELTVVASRSQTRANVVEQLSPPPTSFSLSVAVSSPASAHTHLCYDVARETVAVWRKKGKSSPASEKDAAAGRRSADGDDGHDKQHSRDGAQVPADHDRCVPLFHLFRALSVEGALHIFTGSSSSQPALTVPFAVRVVEPPPRVQRVLIDTSLDCFNPTTATSNLFIAGDDPHESDAGGAGAALRRGRQRQRHERAYAEASGGDHPFTNLALLYLYLRHTLGMAVETFPLLHMSTIATSIAASHSPPLWPPAERTSNVSRTAQRAPAGTLAHIGTLIIVDPERPLTRGMRRLLTRAVLGGGADRSADGLNVLLVTDWYSADLAAQLHWARDESLYDAERFSHINGTDATDEVAGADGDRDAVRDLRALRQSENGSTRGLAGSSHVPSWNRWLSEVTVASGSAANSSDCDGAAPLGSEGLLDGTSELPFELSESIVIDGAVLVDAAAPRRRSEPEGNAFASHGGTVTSAKVVALRSLGQLCAAGVLRWRLPAQAAVQRQAGRATAVGASKGVREPNVYPSGNGTCSTGDASNTSAMPSTQEGEAVICNVMPSWAQQQRRLVKRTVVSTRDGSAPAAVVEDGWEDVPVANGDGRLVRIGGLEAAEVSTMAPAATGASDATQSLTHGVLGFLTLPPSSTLVSTVSANRFRPGRIAIFTDSDCLSASDHHAQAALDELEALLYPPSASPSLPVTTCATWDCFSRTPDGQRLLQAESAQSSVCVEVVKELLLWLHTGNLHRWRDSAQLQCEARTWARARHRSTADTTPGAGSVLEPKAGEDSVEGDRETANFDELLGTAPERAHVGEVVWRLWASLVESTERDAASFLVEGPKEGTRFQGDYAAHQESAAANVMRALMVKYHGDWRAHLLDHNVSPPSTGAAGDSYSQSLRPARGRRSGIATVQQPEQHISLIESLLPLCGMLNALRWLQHPMVLGQLMVSAAVVMSVWLCRAGGGRWRGQRA |
Structure
Family & Domains
Features
Showing features for domain, region, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 128-456 | Peptidase S8/S53 | ||||
Sequence: CAHGTRSVSVLAGQLTVSAPLPREPLEETAWRNRETHLALADQYIGLAPDSTVRVLRIFDRQGRTNRRHLARALDLLLREAEDGEAGRLHSAWNTSSAHIRRRDETVDVISLSYGSKDYHSSPQVQDRLYRLMHEHGVIVVAAAGNDGARFGSVRSPADMPGVLAVGALRMEWHGRSAQTTQASRTLGDLASSLAAGGGHKSVAHFSGRGPTTWELPFGAGRAKPDLVALGQHVWAVQGVSAAAFSAAAPRARSASPALQLRSASGTSIAAPIVAGVVALCLEAAWSSTSAVALAQNMTGGGSFLDVRQNRLARVSDSLRVREVILRTA | ||||||
Region | 466-489 | Disordered | ||||
Sequence: LPPWPHSAPTTPLHSDSSSTASEA | ||||||
Compositional bias | 475-489 | Polar residues | ||||
Sequence: TTPLHSDSSSTASEA | ||||||
Compositional bias | 571-591 | Polar residues | ||||
Sequence: NSNSSSSSSSGDMSTPQSCQP | ||||||
Region | 571-610 | Disordered | ||||
Sequence: NSNSSSSSSSGDMSTPQSCQPPHDPDGKAHGDSPLPGRSG | ||||||
Region | 648-675 | Disordered | ||||
Sequence: SSPAAADQGTRDAAAAASGKGARRGSTT | ||||||
Region | 843-881 | Disordered | ||||
Sequence: KKGKSSPASEKDAAAGRRSADGDDGHDKQHSRDGAQVPA | ||||||
Compositional bias | 856-881 | Basic and acidic residues | ||||
Sequence: AAGRRSADGDDGHDKQHSRDGAQVPA | ||||||
Region | 953-986 | Disordered | ||||
Sequence: IAGDDPHESDAGGAGAALRRGRQRQRHERAYAEA | ||||||
Region | 1297-1322 | Disordered | ||||
Sequence: VREPNVYPSGNGTCSTGDASNTSAMP | ||||||
Compositional bias | 1304-1322 | Polar residues | ||||
Sequence: PSGNGTCSTGDASNTSAMP | ||||||
Region | 1539-1568 | Disordered | ||||
Sequence: ARHRSTADTTPGAGSVLEPKAGEDSVEGDR |
Sequence similarities
Belongs to the peptidase S8 family.
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusComplete
- Length1,744
- Mass (Da)184,712
- Last updated2010-02-09 v1
- Checksum9A312BA038EBFCCA
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 475-489 | Polar residues | ||||
Sequence: TTPLHSDSSSTASEA | ||||||
Compositional bias | 571-591 | Polar residues | ||||
Sequence: NSNSSSSSSSGDMSTPQSCQP | ||||||
Compositional bias | 856-881 | Basic and acidic residues | ||||
Sequence: AAGRRSADGDDGHDKQHSRDGAQVPA | ||||||
Compositional bias | 1304-1322 | Polar residues | ||||
Sequence: PSGNGTCSTGDASNTSAMP |