D2K4C2 · D2K4C2_9TELE
- ProteinRhodopsin
- GeneRH
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids273 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Photoreceptor required for image-forming vision at low light intensity. While most salt water fish species use retinal as chromophore, most freshwater fish use 3-dehydroretinal, or a mixture of retinal and 3-dehydroretinal. Light-induced isomerization of 11-cis to all-trans retinal triggers a conformational change that activates signaling via G-proteins. Subsequent receptor phosphorylation mediates displacement of the bound G-protein alpha subunit by arrestin and terminates signaling.
Features
Showing features for site, binding site.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | membrane | |
Cellular Component | photoreceptor outer segment | |
Molecular Function | G protein-coupled photoreceptor activity | |
Molecular Function | metal ion binding | |
Biological Process | cellular response to light stimulus | |
Biological Process | phototransduction | |
Biological Process | visual perception |
Keywords
- Molecular function
- Biological process
- Ligand
Names & Taxonomy
Protein names
- Recommended nameRhodopsin
Gene names
Organism names
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Actinopterygii > Neopterygii > Teleostei > Neoteleostei > Acanthomorphata > Ovalentaria > Atherinomorphae > Cyprinodontiformes > Poeciliidae > Poeciliinae > Poecilia
Accessions
- Primary accessionD2K4C2
Subcellular Location
UniProt Annotation
GO Annotation
Membrane ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 12-32 | Helical | ||||
Sequence: YMFFLILVGFPINFLTLYVTI | ||||||
Transmembrane | 44-64 | Helical | ||||
Sequence: ILLNLAVADLFMVFGGFTTTI | ||||||
Transmembrane | 84-102 | Helical | ||||
Sequence: YFATLGGEIGLWSLVVLAV | ||||||
Transmembrane | 123-142 | Helical | ||||
Sequence: IMGLVFTWIMANACAAPPLV | ||||||
Transmembrane | 172-192 | Helical | ||||
Sequence: FVIYMFICHFCIPLVIVFFCY | ||||||
Transmembrane | 223-245 | Helical | ||||
Sequence: VVIMVIGFLICWTPYASVAWYIF |
Keywords
- Cellular component
PTM/Processing
Features
Showing features for disulfide bond, modified residue.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Disulfide bond | 79↔156 | |||||
Sequence: CNVEGYFATLGGEIGLWSLVVLAVERWLVVCKPISNFRFGENHAIMGLVFTWIMANACAAPPLVGWSRYIPEGMQCSC | ||||||
Modified residue | 265 | N6-(retinylidene)lysine | ||||
Sequence: K |
Post-translational modification
Contains one covalently linked retinal chromophore.
Keywords
- PTM
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 23-273 | G-protein coupled receptors family 1 profile | ||||
Sequence: INFLTLYVTIEHKKLRTPLNYILLNLAVADLFMVFGGFTTTIYTSMHGYFVLGRLGCNVEGYFATLGGEIGLWSLVVLAVERWLVVCKPISNFRFGENHAIMGLVFTWIMANACAAPPLVGWSRYIPEGMQCSCGIDYYTRAEGFNNESFVIYMFICHFCIPLVIVFFCYGRLLCAVKEAAAAQQESETTQRAEREVTRMVVIMVIGFLICWTPYASVAWYIFTHQGSEFGPLFMTIPAFFAKTASIYNPM |
Sequence similarities
Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.
Keywords
- Domain
Family and domain databases
Protein family/group databases
Sequence
- Sequence statusFragment
- Length273
- Mass (Da)30,779
- Last updated2010-02-09 v1
- Checksum978EC3F2D308A830
Features
Showing features for non-terminal residue.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Non-terminal residue | 1 | |||||
Sequence: V | ||||||
Non-terminal residue | 273 | |||||
Sequence: M |