D2K4A6 · D2K4A6_9TELE

Function

function

Photoreceptor required for image-forming vision at low light intensity. While most salt water fish species use retinal as chromophore, most freshwater fish use 3-dehydroretinal, or a mixture of retinal and 3-dehydroretinal. Light-induced isomerization of 11-cis to all-trans retinal triggers a conformational change that activates signaling via G-proteins. Subsequent receptor phosphorylation mediates displacement of the bound G-protein alpha subunit by arrestin and terminates signaling.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.

Features

Showing features for site, binding site.

127320406080100120140160180200220240260
TypeIDPosition(s)Description
Site82Plays an important role in the conformation switch to the active conformation
Binding site170Zn2+ (UniProtKB | ChEBI)
Binding site248Zn2+ (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentmembrane
Cellular Componentphotoreceptor outer segment
Molecular FunctionG protein-coupled photoreceptor activity
Molecular Functionmetal ion binding
Biological Processcellular response to light stimulus
Biological Processphototransduction
Biological Processvisual perception

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Rhodopsin

Gene names

    • Name
      RH

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Actinopterygii > Neopterygii > Teleostei > Neoteleostei > Acanthomorphata > Ovalentaria > Atherinomorphae > Cyprinodontiformes > Poeciliidae > Poeciliinae > Cnesterodon

Accessions

  • Primary accession
    D2K4A6

Subcellular Location

Membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane12-32Helical
Transmembrane44-64Helical
Transmembrane84-102Helical
Transmembrane123-142Helical
Transmembrane172-192Helical
Transmembrane223-245Helical

Keywords

PTM/Processing

Features

Showing features for disulfide bond, modified residue.

TypeIDPosition(s)Description
Disulfide bond79↔156
Modified residue265N6-(retinylidene)lysine

Post-translational modification

Contains one covalently linked retinal chromophore.

Keywords

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain23-273G-protein coupled receptors family 1 profile

Sequence similarities

Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.

Keywords

Family and domain databases

Protein family/group databases

Sequence

  • Sequence status
    Fragment
  • Length
    273
  • Mass (Da)
    30,823
  • Last updated
    2010-02-09 v1
  • Checksum
    978E2C335D9DC964
VSPAAYFCLGAYMFFLILVGFPINFLTLYVTIEHKKLRTPLNYILLNLAVADLFMVFGGFTTTIYTSMHGYFVLGRLGCNVEGYFATLGGEIGLWSLVVLAVERWLVVCKPISNFRFSENHAIMGLVFTWIMANACAAPPLLGWSRYIPEGMQCSCGIDYYTRAEGFNNESFVIYMFICHFCIPLVIVFFCYGRLLCAVKEAAAAQQESETTQRAEREVTRMVVIMVIGFLICWTPYASVAWYIFTHQGSEFGPLFMTIPAFFAKTASIYNPM

Features

Showing features for non-terminal residue.

TypeIDPosition(s)Description
Non-terminal residue1
Non-terminal residue273

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
GU179271
EMBL· GenBank· DDBJ
ACZ64905.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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