D2JYI1 · D2JYI1_HUMAN
- ProteinTGF-beta receptor type-2
- GeneTGFBR2
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids592 (go to sequence)
- Protein existenceInferred from homology
- Annotation score5/5
Function
function
Transmembrane serine/threonine kinase forming with the TGF-beta type I serine/threonine kinase receptor, TGFBR1, the non-promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinogenesis. The formation of the receptor complex composed of 2 TGFBR1 and 2 TGFBR2 molecules symmetrically bound to the cytokine dimer results in the phosphorylation and the activation of TGFRB1 by the constitutively active TGFBR2. Activated TGFBR1 phosphorylates SMAD2 which dissociates from the receptor and interacts with SMAD4. The SMAD2-SMAD4 complex is subsequently translocated to the nucleus where it modulates the transcription of the TGF-beta-regulated genes. This constitutes the canonical SMAD-dependent TGF-beta signaling cascade. Also involved in non-canonical, SMAD-independent TGF-beta signaling pathways.
Catalytic activity
- ATP + L-seryl-[receptor-protein] = ADP + H+ + O-phospho-L-seryl-[receptor-protein]
Cofactor
Mn2+ (UniProtKB | Rhea| CHEBI:29035 )
Features
Showing features for binding site, active site.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | membrane raft | |
Cellular Component | plasma membrane | |
Cellular Component | receptor complex | |
Molecular Function | activin binding | |
Molecular Function | activin receptor activity | |
Molecular Function | ATP binding | |
Molecular Function | metal ion binding | |
Molecular Function | SMAD binding | |
Molecular Function | transforming growth factor beta binding | |
Molecular Function | transforming growth factor beta receptor activity, type II | |
Molecular Function | type I transforming growth factor beta receptor binding | |
Biological Process | apoptotic process | |
Biological Process | cell differentiation | |
Biological Process | heart development | |
Biological Process | positive regulation of metabolic process | |
Biological Process | regulation of multicellular organismal process | |
Biological Process | transforming growth factor beta receptor signaling pathway |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameTGF-beta receptor type-2
- EC number
- Short namesTGFR-2
- Alternative names
Gene names
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo
Accessions
- Primary accessionD2JYI1
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Cell membrane ; Single-pass type I membrane protein
Membrane ; Single-pass type I membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 185-214 | Helical | ||||
Sequence: LLLVIFQVTGISLLPPLGVAISVIIIFYCY |
Keywords
- Cellular component
PTM/Processing
Features
Showing features for signal, chain, disulfide bond.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Signal | 1-23 | |||||
Sequence: MGRGLLRGLWPLHIVLWTRIAST | ||||||
Chain | PRO_5003033108 | 24-592 | TGF-beta receptor type-2 | |||
Sequence: IPPHVQKSDVEMEAQKDEIICPSCNRTAHPLRHINNDMIVTDNNGAVKFPQLCKFCDVRFSTCDNQKSCMSNCSITSICEKPQEVCVAVWRKNDENITLETVCHDPKLPYHDFILEDAASPKCIMKEKKKPGETFFMCSCSSDECNDNIIFSEEYNTSNPDLLLVIFQVTGISLLPPLGVAISVIIIFYCYRVNRQQKLSSTWETGKTRKLMEFSEHCAIILEDDRSDISSTCANNINHNTELLPIELDTLVGKGRFAEVYKAKLKQNTSEQFETVAVKIFPYEEYASWKTEKDIFSDINLKHENILQFLTAEERKTELGKQYWLITAFHAKGNLQEYLTRHVISWEDLRKLGSSLARGIAHLHSDHTPCGRPKMPIVHRDLKSSNILVKNDLTCCLCDFGLSLRLDPTLSVDDLANSGQVGTARYMAPEVLESRMNLENVESFKQTDVYSMALVLWEMTSRCNAVGEVKDYEPPFGSKVREHPCVESMKDNVLRDRGRPEIPSFWLNHQGIQMVCETLTECWDHDPEARLTAQCVAERFSELEHLDRLSGRSCSEEKIPEDGSLNTTK | ||||||
Disulfide bond | 76↔109 | |||||
Sequence: CKFCDVRFSTCDNQKSCMSNCSITSICEKPQEVC | ||||||
Disulfide bond | 79↔96 | |||||
Sequence: CDVRFSTCDNQKSCMSNC | ||||||
Disulfide bond | 86↔92 | |||||
Sequence: CDNQKSC | ||||||
Disulfide bond | 102↔126 | |||||
Sequence: CEKPQEVCVAVWRKNDENITLETVC | ||||||
Disulfide bond | 146↔161 | |||||
Sequence: CIMKEKKKPGETFFMC | ||||||
Disulfide bond | 163↔168 | |||||
Sequence: CSSDEC |
Keywords
- PTM
Expression
Gene expression databases
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 269-569 | Protein kinase | ||||
Sequence: IELDTLVGKGRFAEVYKAKLKQNTSEQFETVAVKIFPYEEYASWKTEKDIFSDINLKHENILQFLTAEERKTELGKQYWLITAFHAKGNLQEYLTRHVISWEDLRKLGSSLARGIAHLHSDHTPCGRPKMPIVHRDLKSSNILVKNDLTCCLCDFGLSLRLDPTLSVDDLANSGQVGTARYMAPEVLESRMNLENVESFKQTDVYSMALVLWEMTSRCNAVGEVKDYEPPFGSKVREHPCVESMKDNVLRDRGRPEIPSFWLNHQGIQMVCETLTECWDHDPEARLTAQCVAERFSELEHL |
Sequence similarities
Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length592
- Mass (Da)67,457
- Last updated2010-02-09 v1
- Checksum8ADCBA70F95E1CBB
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
GU143403 EMBL· GenBank· DDBJ | ACZ58377.1 EMBL· GenBank· DDBJ | Genomic DNA |