D2JBE4 · D2JBE4_ENTFC

Function

function

Cell wall formation.

Catalytic activity

Cofactor

Protein has several cofactor binding sites:
Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Mn2+ (UniProtKB | Rhea| CHEBI:29035 )

Note: Binds 2 magnesium or manganese ions per subunit.
Mn2+ (UniProtKB | Rhea| CHEBI:29035 )

Pathway

Cell wall biogenesis; peptidoglycan biosynthesis.

Features

Showing features for active site, binding site.

Type
IDPosition(s)Description
Active site16
Binding site133ATP (UniProtKB | ChEBI)
Binding site169-171ATP (UniProtKB | ChEBI)
Active site177
Binding site177-178ATP (UniProtKB | ChEBI)
Binding site207-214ATP (UniProtKB | ChEBI)
Binding site292Mg2+ 1 (UniProtKB | ChEBI)
Binding site304-305ATP (UniProtKB | ChEBI)
Binding site305Mg2+ 2 (UniProtKB | ChEBI)
Binding site305Mg2+ 1 (UniProtKB | ChEBI)
Binding site307Mg2+ 2 (UniProtKB | ChEBI)
Active site316

GO annotations

AspectTerm
Cellular Componentcytosol
Molecular FunctionATP binding
Molecular FunctionD-alanine-D-alanine ligase activity
Molecular Functionmetal ion binding
Biological Processcell wall organization
Biological Processpeptidoglycan biosynthetic process
Biological Processregulation of cell shape

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    D-alanine--D-alanine ligase
  • EC number
  • Alternative names
    • D-Ala-D-Ala ligase
    • D-alanylalanine synthetase

Gene names

    • Name
      vanA
    • Synonyms
      ddl
      , vanB
    • ORF names
      B1P95_18715
      , Efm32007tn_0006
      , GBM44_15900
      , GBM73_16395
      , JCP85_16105
      , SAP083A_022

Encoded on

  • Plasmid p5753cA
  • Plasmid p87_1_57kb
  • Plasmid pF856
  • Plasmid pS177

Organism names

  • Taxonomic identifier
  • Strains
    • 5753c
    • S177
    • VREfm 320/07
    • LIM1759
    • VRECG10
  • Taxonomic lineage
    Bacteria > Bacillota > Bacilli > Lactobacillales > Enterococcaceae > Enterococcus

Accessions

  • Primary accession
    D2JBE4

Proteomes

Subcellular Location

Keywords

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain137-338ATP-grasp

Sequence similarities

Belongs to the D-alanine--D-alanine ligase family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    343
  • Mass (Da)
    37,415
  • Last updated
    2010-02-09 v1
  • Checksum
    5AA4993B24F0056E
MNRIKVAILFGGCSEEHDVSVKSAIEIAANINKEKYEPLYIGITKSGVWKMCEKPCAEWENDNCYSAVLSPDKKMHGLLVKKNHEYEINHVDVAFSALHGKSGEDGSIQGLFELSGIPFVGCDIQSSAICMDKSLTYIVAKNAGIATPAFWVINKDDRPVAATFTYPVFVKPARSGSSFGVKKVNSADELDYAIESARQYDSKILIEQAVSGCEVGCAVLGNSAALAVGEVDQIRLQYGIFRIHQEVEPEKGSENAVITVPADLSAEERGRIQETAKKIYKALGCRGLARVDMFLQDNGRIVLNEVNTLPGFTSYSRYPRMMAAAGIALPELIDRLIVLALKG

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
GQ900435
EMBL· GenBank· DDBJ
ADA62243.1
EMBL· GenBank· DDBJ
Genomic DNA
HQ115078
EMBL· GenBank· DDBJ
ADV60062.1
EMBL· GenBank· DDBJ
Genomic DNA
JQ663598
EMBL· GenBank· DDBJ
AFV27319.1
EMBL· GenBank· DDBJ
Genomic DNA
KR349520
EMBL· GenBank· DDBJ
AKL90235.1
EMBL· GenBank· DDBJ
Genomic DNA
WEFP01000006
EMBL· GenBank· DDBJ
KAB7572422.1
EMBL· GenBank· DDBJ
Genomic DNA
WEGG01000006
EMBL· GenBank· DDBJ
KAB7614050.1
EMBL· GenBank· DDBJ
Genomic DNA
MVGJ01000665
EMBL· GenBank· DDBJ
OOL76090.1
EMBL· GenBank· DDBJ
Genomic DNA
CP066461
EMBL· GenBank· DDBJ
QQF34307.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

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