D2H5P6 · ZFY26_AILME
- ProteinZinc finger FYVE domain-containing protein 26
- GeneZFYVE26
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids2543 (go to sequence)
- Protein existenceInferred from homology
- Annotation score4/5
Function
function
Phosphatidylinositol 3-phosphate-binding protein required for the abscission step in cytokinesis: recruited to the midbody during cytokinesis and acts as a regulator of abscission. May also be required for efficient homologous recombination DNA double-strand break repair (By similarity).
Features
Showing features for binding site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 1822 | Zn2+ 1 (UniProtKB | ChEBI) | ||||
Sequence: C | ||||||
Binding site | 1825 | Zn2+ 1 (UniProtKB | ChEBI) | ||||
Sequence: C | ||||||
Binding site | 1839 | Zn2+ 2 (UniProtKB | ChEBI) | ||||
Sequence: C | ||||||
Binding site | 1842 | Zn2+ 2 (UniProtKB | ChEBI) | ||||
Sequence: C | ||||||
Binding site | 1847 | Zn2+ 1 (UniProtKB | ChEBI) | ||||
Sequence: C | ||||||
Binding site | 1850 | Zn2+ 1 (UniProtKB | ChEBI) | ||||
Sequence: C | ||||||
Binding site | 1868 | Zn2+ 2 (UniProtKB | ChEBI) | ||||
Sequence: C | ||||||
Binding site | 1871 | Zn2+ 2 (UniProtKB | ChEBI) | ||||
Sequence: C |
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | centrosome | |
Cellular Component | early endosome | |
Cellular Component | late endosome | |
Cellular Component | lysosome | |
Cellular Component | midbody | |
Molecular Function | metal ion binding | |
Molecular Function | phosphatidylinositol-3-phosphate binding | |
Molecular Function | protein kinase binding | |
Biological Process | autophagosome organization | |
Biological Process | double-strand break repair via homologous recombination | |
Biological Process | lysosome organization | |
Biological Process | mitotic cytokinesis | |
Biological Process | regulation of cytokinesis |
Keywords
- Biological process
- Ligand
Names & Taxonomy
Protein names
- Recommended nameZinc finger FYVE domain-containing protein 26
Gene names
Organism names
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Laurasiatheria > Carnivora > Caniformia > Ursidae > Ailuropoda
Accessions
- Primary accessionD2H5P6
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Note: Localizes to the centrosome during all stages of the cell cycle. Recruited to the midbody during cytokinesis by KIF13A (By similarity).
Keywords
- Cellular component
PTM/Processing
Features
Showing features for chain, modified residue.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000408350 | 1-2543 | Zinc finger FYVE domain-containing protein 26 | |||
Sequence: MHHPFGKEETASQKQLFGFFCECLRRGEWELAQACVPQLHEAQGDIPKKVEDILQALVVCPDQLRCGQDIDPQRLAWVWFLVLEKWFSQEKKLLPSVFRRKLEFLLLSEDLRRDIPEDILKELYEALAQDTGGPVLDGNQKRESWTPRLSSEAVSVFWDLLRQAPQLAQALLELLRTKDDSAGLSGWSLQKALVDRVRRALGAVQGPTTGPAGIVDAIYGALRSLRCPAEPLGGELRLLCEELLEACRAEGSPLQEEQVLSCLLHKAGRSLVSLYGHIYAEKATEKPAKAVHLGKVSPDHLDPEQAMLALFCNPDPSQAWKSAYFYCLSNSKHFLEQILVTALALLKEEDFPSLGCLLDREFRPLSRLLVLLGWMHCQSLASAKRLLQTLHRAQDQGCDKLLRDACDGLWAHLEVLEWCVQQSSNPIPKRDLLCHLHGGDSHSVLYSLHHLTNLPALREEDVLKLLQKVPAKDPQQEQDSAEAPVPEHLSRCQNLTLYQSFCAMKYAIYALCVNSHQHSQCQECRDSPSEDPALAAEPANDSLSSPGASDLFSTYLARCQQYLCNVPDSLCLELLENIFSLLLITSADLHPEPHLPEDYAEDEDIEGKGLLGLRSPSESPQHIAQPERKSEQGCQEVPRSLACTVPNCLKTEPKESSPGLHGHSFLDLKHFTSGISGFLADEFAIGAFFRLLQEQLDKLSSHSPPEKPKLPEGQSCSGSRDGLQSRLHRFSKVLSEAQWRYKVVTSNQGSEEQPSRRYWPIATGHPSLRRGRRTRRSRPDGRDRSSNPSLESTSSELSTSTSEGSLNAVSGRNELDGRLQPQSQNSLIPMMFSPPESLLASCILRGNFAEAHQVVFMFNLKSSPSSGELMFMERYQEVIQELSRVEHKIENQNSDGGSSTIRRTGSGRSTLQAIGSAAAAGMVFYSISDVTDKLLSTSGEPIPTLQEDFWISNTLVEPTAPLREVLEDLSPPAMAAFDLACSQCQLWKTCKQLLETAERRLNVSLESRGRRLDHILLSADGIRGFPVVLQQISKILNYPLTSAGQSKSESVEEKGAGPPRCSIAELLQMCWPSLTEDCVASHATLSQQLDQVLQVLREALQRPEPRSTPLSSLVEQAAQKAPEAEAHPVHIQTQLLQKNLGKQTPAGSRQTDYMGTFFSYCNTMAAVLLRSLSSEPDHMEVKVGNPFVLLQQSSSQLVSHLLLERQVPPDRLAALLAREGLSLSVPKVIVNCCCEPLALCSSRQSQQTSSLLTHLDVLVQLHTSHCLEDLPLSTLSSPKPTGNSTLERKPHSSPRDSSLPAFTSSALAFLKSRSKLLATVACLGASQGPKLTKPSLSWKELRGRREVPLSAEQVAQECERLLEQFPMLKASLLAAWEPLRRSTEQGQSLAVSLCGRASLSTVLLGLHSPSALDVLTEAFEEALVARDWSRALQLTEVYGRDVDDLSNIKDAVLSCATACDKEGWRFLFPVKDASLRSRLTLQFVDRWPLEWCLEILAYCISDTAVQGGLKCELQRKLAELRVYQKILGLQATPVWCDWQSLRNCCIEDPSAVMNMILEAKEYGLCEEWGCLYPIPREHLISLHQKHLLHLLERGDHEKALQLLRKIPDPTMCLEVTEQSLDQHPSLAASHFLANYLTTHFYGELTAVRHHEIQALYMGSKVLLTLPEPHRASYSHLSSNPLLMLEQLLMNMKVDWATVAVQTLHQLLAGQEIGFTMDDIDSLLSIYAGKALDFPYSLREKRSDSLTHLQEVSQPSDLVTLSRSPSGEFSVAAAVAAPGVSTIHSPSPRERSFPESQPPPEFVPPATPPGRPQWVPDESASICMVCCRERFTMFNRRHHCRRCGRLVCSACSTKKMVVEGCRESPTRVCDQCYSYYNKDVPEENAGQPEAPDSSKSESPPYSAVVRVPKAAEVEWILDLNEEENELVRSEFYYEQSPSASLCIAILNLHRDSIACGHQLIEHCCRLSQGLTNPEVDAGLLTDIMKQLLFSAKMMFVKAGRSQDLALCDSYISKVDVLNILVAASYRHVPPLDQILQPAAVTRLRNQLLEAEYYQLGVEISTKTGLDPTGAWHAWGMACLKAGNLTAAREKFGRCLKPPFDLNQLSHGSRLVQDVVEYLESTVRPLLSLQDDDYFATLKELEATLRTQSLSLEVIPEGKIMNNTYYQECLFYLHNYSTNLAIISFYMRHSCMREALLHLLNKESPPEVFIEGIFQPSYKSGKLHTLENLLESIDPTLETWGKYLIAACQHLQKKNYYHILYELQQFMKDQVRAAMTCIRFFSHKAKTYTELGEKLSWLLKAKDHLKIYLQDTSRSTRRKKTTFFQKKMTAADVSRHMNTLQLQMEVTRFLHRCESAGTSQITTLPLPTLFGNNHMKMDVACKVMLGGKNVEDGFGIAFRVLQDFQLDAAATYCRAARQLVEREKYSEIQQLLKCVSESGMAATSDGDTILLNCLEAFKRIPPQELEGLIQAIHSDDNKVQAYLTCCKLRSAYLIAVKQEHSRATVLVQQVQQAAKSSGDAVVQDICAQWLLTSHTRGSHGSGSRK | ||||||
Modified residue | 297 | Phosphoserine | ||||
Sequence: S | ||||||
Modified residue | 615 | Phosphoserine | ||||
Sequence: S | ||||||
Modified residue | 619 | Phosphoserine | ||||
Sequence: S | ||||||
Modified residue | 703 | Phosphoserine | ||||
Sequence: S | ||||||
Modified residue | 802 | Phosphoserine | ||||
Sequence: S | ||||||
Modified residue | 1744 | Phosphoserine | ||||
Sequence: S | ||||||
Modified residue | 1765 | Phosphoserine | ||||
Sequence: S | ||||||
Modified residue | 1784 | Phosphoserine | ||||
Sequence: S | ||||||
Modified residue | 1786 | Phosphoserine | ||||
Sequence: S |
Keywords
- PTM
Interaction
Subunit
Interacts with AP5Z1, AP5B1, AP5S1 and SPG11. Interacts with TTC19 and KIF13A (By similarity).
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for region, compositional bias, coiled coil, zinc finger.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 523-545 | Disordered | ||||
Sequence: ECRDSPSEDPALAAEPANDSLSS | ||||||
Region | 609-636 | Disordered | ||||
Sequence: GLLGLRSPSESPQHIAQPERKSEQGCQE | ||||||
Region | 699-722 | Disordered | ||||
Sequence: LSSHSPPEKPKLPEGQSCSGSRDG | ||||||
Region | 744-820 | Disordered | ||||
Sequence: VTSNQGSEEQPSRRYWPIATGHPSLRRGRRTRRSRPDGRDRSSNPSLESTSSELSTSTSEGSLNAVSGRNELDGRLQ | ||||||
Compositional bias | 786-809 | Polar residues | ||||
Sequence: SNPSLESTSSELSTSTSEGSLNAV | ||||||
Coiled coil | 870-897 | |||||
Sequence: MFMERYQEVIQELSRVEHKIENQNSDGG | ||||||
Compositional bias | 1272-1288 | Polar residues | ||||
Sequence: LSTLSSPKPTGNSTLER | ||||||
Region | 1272-1299 | Disordered | ||||
Sequence: LSTLSSPKPTGNSTLERKPHSSPRDSSL | ||||||
Region | 1780-1812 | Disordered | ||||
Sequence: STIHSPSPRERSFPESQPPPEFVPPATPPGRPQ | ||||||
Compositional bias | 1791-1811 | Pro residues | ||||
Sequence: SFPESQPPPEFVPPATPPGRP | ||||||
Zinc finger | 1816-1876 | FYVE-type | ||||
Sequence: DESASICMVCCRERFTMFNRRHHCRRCGRLVCSACSTKKMVVEGCRESPTRVCDQCYSYYN |
Domain
The FYVE-type zinc finger mediates binding to phosphatidylinositol 3-phosphate and recruitment to the midbody during cytokinesis.
Sequence similarities
Belongs to the ZFYVE26 family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length2,543
- Mass (Da)283,930
- Last updated2010-02-09 v1
- ChecksumA589BB2417A0D2E3
Computationally mapped potential isoform sequences
There is 1 potential isoform mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
G1M6Z2 | G1M6Z2_AILME | ZFYVE26 | 2545 |
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 786-809 | Polar residues | ||||
Sequence: SNPSLESTSSELSTSTSEGSLNAV | ||||||
Compositional bias | 1272-1288 | Polar residues | ||||
Sequence: LSTLSSPKPTGNSTLER | ||||||
Compositional bias | 1791-1811 | Pro residues | ||||
Sequence: SFPESQPPPEFVPPATPPGRP |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
GL192509 EMBL· GenBank· DDBJ | EFB24961.1 EMBL· GenBank· DDBJ | Genomic DNA |