D2CYA7 · D2CYA7_ANOAL
- ProteinCytochrome c oxidase subunit 1
- GeneCOI
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids353 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
Catalytic activity
- 4 Fe(II)-[cytochrome c] + O2 + 8 H+(in) = 4 Fe(III)-[cytochrome c] + 2 H2O + 4 H+(out)This reaction proceeds in the forward direction.
4 RHEA-COMP:10350 + CHEBI:15379 + 8 H+ (in)CHEBI:15378= 4 RHEA-COMP:14399 + 2 CHEBI:15377 + 4 H+ (out)CHEBI:15378
Cofactor
Pathway
Energy metabolism; oxidative phosphorylation.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | mitochondrial inner membrane | |
Cellular Component | respiratory chain complex IV | |
Molecular Function | cytochrome-c oxidase activity | |
Molecular Function | heme binding | |
Molecular Function | metal ion binding | |
Biological Process | electron transport coupled proton transport | |
Biological Process | mitochondrial electron transport, cytochrome c to oxygen |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameCytochrome c oxidase subunit 1
- EC number
Gene names
Encoded on
- Mitochondrion
Organism names
- Taxonomic lineageEukaryota > Metazoa > Ecdysozoa > Arthropoda > Hexapoda > Insecta > Pterygota > Neoptera > Endopterygota > Diptera > Nematocera > Culicoidea > Culicidae > Anophelinae > Anopheles
Accessions
- Primary accessionD2CYA7
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Mitochondrion inner membrane ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 20-43 | Helical | ||||
Sequence: FSLHLAGISSILGAVNFITTVINM | ||||||
Transmembrane | 55-82 | Helical | ||||
Sequence: LFVWSVVITAVLLLLSLPVLAGAITMLL | ||||||
Transmembrane | 115-131 | Helical | ||||
Sequence: VYILILPGFGMISHIIT | ||||||
Transmembrane | 143-163 | Helical | ||||
Sequence: LGMIYAMLAIGLLGFIVWAHH | ||||||
Transmembrane | 175-197 | Helical | ||||
Sequence: AYFTSATMIIAVPTGIKIFSWLA | ||||||
Transmembrane | 209-231 | Helical | ||||
Sequence: AMLWAFGFVFLFTVGGLTGVVLA | ||||||
Transmembrane | 251-272 | Helical | ||||
Sequence: YVLSMGAVFAIMAGFIHWYPLL | ||||||
Transmembrane | 284-302 | Helical | ||||
Sequence: IQFSMMFVGVNLTFFPQHF | ||||||
Transmembrane | 322-345 | Helical | ||||
Sequence: WNIVSSLGSTISLFAILYFLFIIW |
Keywords
- Cellular component
Interaction
Subunit
Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of a catalytic core of 3 subunits and several supernumerary subunits. The complex exists as a monomer or a dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII).
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 1-353 | Cytochrome oxidase subunit I profile | ||||
Sequence: YPPLSSGIAHAGASVDLAIFSLHLAGISSILGAVNFITTVINMRSPGITLDRMPLFVWSVVITAVLLLLSLPVLAGAITMLLTDRNLNTSFFDPAGGGDPILYQHLFWFFGHPEVYILILPGFGMISHIITQESGKKETFGNLGMIYAMLAIGLLGFIVWAHHMFTVGMDVDTRAYFTSATMIIAVPTGIKIFSWLATLHGTQLTYSPAMLWAFGFVFLFTVGGLTGVVLANSSIDIVLHDTYYVVAHFHYVLSMGAVFAIMAGFIHWYPLLTGLTMNPTWLKIQFSMMFVGVNLTFFPQHFLGLAGMPRRYSDFPDSYLTWNIVSSLGSTISLFAILYFLFIIWESMITQRT |
Sequence similarities
Belongs to the heme-copper respiratory oxidase family.
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusFragment
- Length353
- Mass (Da)38,998
- Last updated2010-02-09 v1
- Checksum0A3E4C4EAB7834B0
Features
Showing features for non-terminal residue.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Non-terminal residue | 1 | |||||
Sequence: Y | ||||||
Non-terminal residue | 353 | |||||
Sequence: T |
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
FJ015158 EMBL· GenBank· DDBJ | ACM48355.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
FJ015159 EMBL· GenBank· DDBJ | ACM48356.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
FJ015160 EMBL· GenBank· DDBJ | ACM48357.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
FJ015161 EMBL· GenBank· DDBJ | ACM48358.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
FJ015162 EMBL· GenBank· DDBJ | ACM48359.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
FJ015163 EMBL· GenBank· DDBJ | ACM48360.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
FJ015164 EMBL· GenBank· DDBJ | ACM48361.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
FJ015166 EMBL· GenBank· DDBJ | ACM48363.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
FJ015167 EMBL· GenBank· DDBJ | ACM48364.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
FJ015168 EMBL· GenBank· DDBJ | ACM48365.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
FJ015169 EMBL· GenBank· DDBJ | ACM48366.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
FJ015170 EMBL· GenBank· DDBJ | ACM48367.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
FJ015171 EMBL· GenBank· DDBJ | ACM48368.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
FJ015172 EMBL· GenBank· DDBJ | ACM48369.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
FJ015173 EMBL· GenBank· DDBJ | ACM48370.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
FJ015174 EMBL· GenBank· DDBJ | ACM48371.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
FJ015175 EMBL· GenBank· DDBJ | ACM48372.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
FJ015177 EMBL· GenBank· DDBJ | ACM48374.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
FJ015179 EMBL· GenBank· DDBJ | ACM48376.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
FJ015181 EMBL· GenBank· DDBJ | ACM48378.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
FJ015182 EMBL· GenBank· DDBJ | ACM48379.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
FJ015183 EMBL· GenBank· DDBJ | ACM48380.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
FJ015184 EMBL· GenBank· DDBJ | ACM48381.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
FJ015185 EMBL· GenBank· DDBJ | ACM48382.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
FJ015187 EMBL· GenBank· DDBJ | ACM48384.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
FJ015188 EMBL· GenBank· DDBJ | ACM48385.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
FJ015189 EMBL· GenBank· DDBJ | ACM48386.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
FJ015190 EMBL· GenBank· DDBJ | ACM48387.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
FJ015191 EMBL· GenBank· DDBJ | ACM48388.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
FJ015192 EMBL· GenBank· DDBJ | ACM48389.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
FJ015193 EMBL· GenBank· DDBJ | ACM48390.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
FJ015194 EMBL· GenBank· DDBJ | ACM48391.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
FJ015195 EMBL· GenBank· DDBJ | ACM48392.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
FJ015196 EMBL· GenBank· DDBJ | ACM48393.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
FJ015197 EMBL· GenBank· DDBJ | ACM48394.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
FJ015198 EMBL· GenBank· DDBJ | ACM48395.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
FJ015199 EMBL· GenBank· DDBJ | ACM48396.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
FJ015202 EMBL· GenBank· DDBJ | ACM48399.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
FJ015203 EMBL· GenBank· DDBJ | ACM48400.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
FJ015204 EMBL· GenBank· DDBJ | ACM48401.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
FJ015205 EMBL· GenBank· DDBJ | ACM48402.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
FJ015206 EMBL· GenBank· DDBJ | ACM48403.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
FJ015207 EMBL· GenBank· DDBJ | ACM48404.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
FJ015208 EMBL· GenBank· DDBJ | ACM48405.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
FJ015212 EMBL· GenBank· DDBJ | ACM48409.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
FJ015213 EMBL· GenBank· DDBJ | ACM48410.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
FJ015214 EMBL· GenBank· DDBJ | ACM48411.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
FJ015215 EMBL· GenBank· DDBJ | ACM48412.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
FJ015216 EMBL· GenBank· DDBJ | ACM48413.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
FJ015217 EMBL· GenBank· DDBJ | ACM48414.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
FJ015218 EMBL· GenBank· DDBJ | ACM48415.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
FJ015219 EMBL· GenBank· DDBJ | ACM48416.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
FJ015220 EMBL· GenBank· DDBJ | ACM48417.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
FJ015221 EMBL· GenBank· DDBJ | ACM48418.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
FJ015222 EMBL· GenBank· DDBJ | ACM48419.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
FJ015223 EMBL· GenBank· DDBJ | ACM48420.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
FJ015225 EMBL· GenBank· DDBJ | ACM48422.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
FJ015226 EMBL· GenBank· DDBJ | ACM48423.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
FJ015227 EMBL· GenBank· DDBJ | ACM48424.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
FJ015228 EMBL· GenBank· DDBJ | ACM48425.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
FJ015229 EMBL· GenBank· DDBJ | ACM48426.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
FJ015230 EMBL· GenBank· DDBJ | ACM48427.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
FJ015231 EMBL· GenBank· DDBJ | ACM48428.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
FJ015232 EMBL· GenBank· DDBJ | ACM48429.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
FJ015233 EMBL· GenBank· DDBJ | ACM48430.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
FJ015235 EMBL· GenBank· DDBJ | ACM48432.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
FJ015237 EMBL· GenBank· DDBJ | ACM48434.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
FJ015238 EMBL· GenBank· DDBJ | ACM48435.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
FJ015239 EMBL· GenBank· DDBJ | ACM48436.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
FJ015240 EMBL· GenBank· DDBJ | ACM48437.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
FJ015241 EMBL· GenBank· DDBJ | ACM48438.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
FJ015243 EMBL· GenBank· DDBJ | ACM48440.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
FJ015244 EMBL· GenBank· DDBJ | ACM48441.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
FJ015245 EMBL· GenBank· DDBJ | ACM48442.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
FJ015246 EMBL· GenBank· DDBJ | ACM48443.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
FJ015247 EMBL· GenBank· DDBJ | ACM48444.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
FJ015249 EMBL· GenBank· DDBJ | ACM48446.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
FJ015250 EMBL· GenBank· DDBJ | ACM48447.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
FJ015251 EMBL· GenBank· DDBJ | ACM48448.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
FJ015252 EMBL· GenBank· DDBJ | ACM48449.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
FJ015254 EMBL· GenBank· DDBJ | ACM48451.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
FJ015256 EMBL· GenBank· DDBJ | ACM48453.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
FJ015257 EMBL· GenBank· DDBJ | ACM48454.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
FJ015258 EMBL· GenBank· DDBJ | ACM48455.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
FJ015259 EMBL· GenBank· DDBJ | ACM48456.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
FJ015260 EMBL· GenBank· DDBJ | ACM48457.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
FJ015261 EMBL· GenBank· DDBJ | ACM48458.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
FJ015262 EMBL· GenBank· DDBJ | ACM48459.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
FJ015263 EMBL· GenBank· DDBJ | ACM48460.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
FJ015264 EMBL· GenBank· DDBJ | ACM48461.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
FJ015265 EMBL· GenBank· DDBJ | ACM48462.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
FJ015266 EMBL· GenBank· DDBJ | ACM48463.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
FJ015267 EMBL· GenBank· DDBJ | ACM48464.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
FJ015268 EMBL· GenBank· DDBJ | ACM48465.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
FJ015269 EMBL· GenBank· DDBJ | ACM48466.1 EMBL· GenBank· DDBJ | Genomic DNA |