D2CYA7 · D2CYA7_ANOAL

Function

function

Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.

Catalytic activity

Cofactor

heme (UniProtKB | Rhea| CHEBI:30413 )

Pathway

Energy metabolism; oxidative phosphorylation.

GO annotations

AspectTerm
Cellular Componentmitochondrial inner membrane
Cellular Componentrespiratory chain complex IV
Molecular Functioncytochrome-c oxidase activity
Molecular Functionheme binding
Molecular Functionmetal ion binding
Biological Processelectron transport coupled proton transport
Biological Processmitochondrial electron transport, cytochrome c to oxygen

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Cytochrome c oxidase subunit 1
  • EC number

Gene names

    • Name
      COI

Encoded on

  • Mitochondrion

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Ecdysozoa > Arthropoda > Hexapoda > Insecta > Pterygota > Neoptera > Endopterygota > Diptera > Nematocera > Culicoidea > Culicidae > Anophelinae > Anopheles

Accessions

  • Primary accession
    D2CYA7

Organism-specific databases

Subcellular Location

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane20-43Helical
Transmembrane55-82Helical
Transmembrane115-131Helical
Transmembrane143-163Helical
Transmembrane175-197Helical
Transmembrane209-231Helical
Transmembrane251-272Helical
Transmembrane284-302Helical
Transmembrane322-345Helical

Keywords

Interaction

Subunit

Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of a catalytic core of 3 subunits and several supernumerary subunits. The complex exists as a monomer or a dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII).

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain1-353Cytochrome oxidase subunit I profile

Sequence similarities

Belongs to the heme-copper respiratory oxidase family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Fragment
  • Length
    353
  • Mass (Da)
    38,998
  • Last updated
    2010-02-09 v1
  • Checksum
    0A3E4C4EAB7834B0
YPPLSSGIAHAGASVDLAIFSLHLAGISSILGAVNFITTVINMRSPGITLDRMPLFVWSVVITAVLLLLSLPVLAGAITMLLTDRNLNTSFFDPAGGGDPILYQHLFWFFGHPEVYILILPGFGMISHIITQESGKKETFGNLGMIYAMLAIGLLGFIVWAHHMFTVGMDVDTRAYFTSATMIIAVPTGIKIFSWLATLHGTQLTYSPAMLWAFGFVFLFTVGGLTGVVLANSSIDIVLHDTYYVVAHFHYVLSMGAVFAIMAGFIHWYPLLTGLTMNPTWLKIQFSMMFVGVNLTFFPQHFLGLAGMPRRYSDFPDSYLTWNIVSSLGSTISLFAILYFLFIIWESMITQRT

Features

Showing features for non-terminal residue.

TypeIDPosition(s)Description
Non-terminal residue1
Non-terminal residue353

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
FJ015158
EMBL· GenBank· DDBJ
ACM48355.1
EMBL· GenBank· DDBJ
Genomic DNA
FJ015159
EMBL· GenBank· DDBJ
ACM48356.1
EMBL· GenBank· DDBJ
Genomic DNA
FJ015160
EMBL· GenBank· DDBJ
ACM48357.1
EMBL· GenBank· DDBJ
Genomic DNA
FJ015161
EMBL· GenBank· DDBJ
ACM48358.1
EMBL· GenBank· DDBJ
Genomic DNA
FJ015162
EMBL· GenBank· DDBJ
ACM48359.1
EMBL· GenBank· DDBJ
Genomic DNA
FJ015163
EMBL· GenBank· DDBJ
ACM48360.1
EMBL· GenBank· DDBJ
Genomic DNA
FJ015164
EMBL· GenBank· DDBJ
ACM48361.1
EMBL· GenBank· DDBJ
Genomic DNA
FJ015166
EMBL· GenBank· DDBJ
ACM48363.1
EMBL· GenBank· DDBJ
Genomic DNA
FJ015167
EMBL· GenBank· DDBJ
ACM48364.1
EMBL· GenBank· DDBJ
Genomic DNA
FJ015168
EMBL· GenBank· DDBJ
ACM48365.1
EMBL· GenBank· DDBJ
Genomic DNA
FJ015169
EMBL· GenBank· DDBJ
ACM48366.1
EMBL· GenBank· DDBJ
Genomic DNA
FJ015170
EMBL· GenBank· DDBJ
ACM48367.1
EMBL· GenBank· DDBJ
Genomic DNA
FJ015171
EMBL· GenBank· DDBJ
ACM48368.1
EMBL· GenBank· DDBJ
Genomic DNA
FJ015172
EMBL· GenBank· DDBJ
ACM48369.1
EMBL· GenBank· DDBJ
Genomic DNA
FJ015173
EMBL· GenBank· DDBJ
ACM48370.1
EMBL· GenBank· DDBJ
Genomic DNA
FJ015174
EMBL· GenBank· DDBJ
ACM48371.1
EMBL· GenBank· DDBJ
Genomic DNA
FJ015175
EMBL· GenBank· DDBJ
ACM48372.1
EMBL· GenBank· DDBJ
Genomic DNA
FJ015177
EMBL· GenBank· DDBJ
ACM48374.1
EMBL· GenBank· DDBJ
Genomic DNA
FJ015179
EMBL· GenBank· DDBJ
ACM48376.1
EMBL· GenBank· DDBJ
Genomic DNA
FJ015181
EMBL· GenBank· DDBJ
ACM48378.1
EMBL· GenBank· DDBJ
Genomic DNA
FJ015182
EMBL· GenBank· DDBJ
ACM48379.1
EMBL· GenBank· DDBJ
Genomic DNA
FJ015183
EMBL· GenBank· DDBJ
ACM48380.1
EMBL· GenBank· DDBJ
Genomic DNA
FJ015184
EMBL· GenBank· DDBJ
ACM48381.1
EMBL· GenBank· DDBJ
Genomic DNA
FJ015185
EMBL· GenBank· DDBJ
ACM48382.1
EMBL· GenBank· DDBJ
Genomic DNA
FJ015187
EMBL· GenBank· DDBJ
ACM48384.1
EMBL· GenBank· DDBJ
Genomic DNA
FJ015188
EMBL· GenBank· DDBJ
ACM48385.1
EMBL· GenBank· DDBJ
Genomic DNA
FJ015189
EMBL· GenBank· DDBJ
ACM48386.1
EMBL· GenBank· DDBJ
Genomic DNA
FJ015190
EMBL· GenBank· DDBJ
ACM48387.1
EMBL· GenBank· DDBJ
Genomic DNA
FJ015191
EMBL· GenBank· DDBJ
ACM48388.1
EMBL· GenBank· DDBJ
Genomic DNA
FJ015192
EMBL· GenBank· DDBJ
ACM48389.1
EMBL· GenBank· DDBJ
Genomic DNA
FJ015193
EMBL· GenBank· DDBJ
ACM48390.1
EMBL· GenBank· DDBJ
Genomic DNA
FJ015194
EMBL· GenBank· DDBJ
ACM48391.1
EMBL· GenBank· DDBJ
Genomic DNA
FJ015195
EMBL· GenBank· DDBJ
ACM48392.1
EMBL· GenBank· DDBJ
Genomic DNA
FJ015196
EMBL· GenBank· DDBJ
ACM48393.1
EMBL· GenBank· DDBJ
Genomic DNA
FJ015197
EMBL· GenBank· DDBJ
ACM48394.1
EMBL· GenBank· DDBJ
Genomic DNA
FJ015198
EMBL· GenBank· DDBJ
ACM48395.1
EMBL· GenBank· DDBJ
Genomic DNA
FJ015199
EMBL· GenBank· DDBJ
ACM48396.1
EMBL· GenBank· DDBJ
Genomic DNA
FJ015202
EMBL· GenBank· DDBJ
ACM48399.1
EMBL· GenBank· DDBJ
Genomic DNA
FJ015203
EMBL· GenBank· DDBJ
ACM48400.1
EMBL· GenBank· DDBJ
Genomic DNA
FJ015204
EMBL· GenBank· DDBJ
ACM48401.1
EMBL· GenBank· DDBJ
Genomic DNA
FJ015205
EMBL· GenBank· DDBJ
ACM48402.1
EMBL· GenBank· DDBJ
Genomic DNA
FJ015206
EMBL· GenBank· DDBJ
ACM48403.1
EMBL· GenBank· DDBJ
Genomic DNA
FJ015207
EMBL· GenBank· DDBJ
ACM48404.1
EMBL· GenBank· DDBJ
Genomic DNA
FJ015208
EMBL· GenBank· DDBJ
ACM48405.1
EMBL· GenBank· DDBJ
Genomic DNA
FJ015212
EMBL· GenBank· DDBJ
ACM48409.1
EMBL· GenBank· DDBJ
Genomic DNA
FJ015213
EMBL· GenBank· DDBJ
ACM48410.1
EMBL· GenBank· DDBJ
Genomic DNA
FJ015214
EMBL· GenBank· DDBJ
ACM48411.1
EMBL· GenBank· DDBJ
Genomic DNA
FJ015215
EMBL· GenBank· DDBJ
ACM48412.1
EMBL· GenBank· DDBJ
Genomic DNA
FJ015216
EMBL· GenBank· DDBJ
ACM48413.1
EMBL· GenBank· DDBJ
Genomic DNA
FJ015217
EMBL· GenBank· DDBJ
ACM48414.1
EMBL· GenBank· DDBJ
Genomic DNA
FJ015218
EMBL· GenBank· DDBJ
ACM48415.1
EMBL· GenBank· DDBJ
Genomic DNA
FJ015219
EMBL· GenBank· DDBJ
ACM48416.1
EMBL· GenBank· DDBJ
Genomic DNA
FJ015220
EMBL· GenBank· DDBJ
ACM48417.1
EMBL· GenBank· DDBJ
Genomic DNA
FJ015221
EMBL· GenBank· DDBJ
ACM48418.1
EMBL· GenBank· DDBJ
Genomic DNA
FJ015222
EMBL· GenBank· DDBJ
ACM48419.1
EMBL· GenBank· DDBJ
Genomic DNA
FJ015223
EMBL· GenBank· DDBJ
ACM48420.1
EMBL· GenBank· DDBJ
Genomic DNA
FJ015225
EMBL· GenBank· DDBJ
ACM48422.1
EMBL· GenBank· DDBJ
Genomic DNA
FJ015226
EMBL· GenBank· DDBJ
ACM48423.1
EMBL· GenBank· DDBJ
Genomic DNA
FJ015227
EMBL· GenBank· DDBJ
ACM48424.1
EMBL· GenBank· DDBJ
Genomic DNA
FJ015228
EMBL· GenBank· DDBJ
ACM48425.1
EMBL· GenBank· DDBJ
Genomic DNA
FJ015229
EMBL· GenBank· DDBJ
ACM48426.1
EMBL· GenBank· DDBJ
Genomic DNA
FJ015230
EMBL· GenBank· DDBJ
ACM48427.1
EMBL· GenBank· DDBJ
Genomic DNA
FJ015231
EMBL· GenBank· DDBJ
ACM48428.1
EMBL· GenBank· DDBJ
Genomic DNA
FJ015232
EMBL· GenBank· DDBJ
ACM48429.1
EMBL· GenBank· DDBJ
Genomic DNA
FJ015233
EMBL· GenBank· DDBJ
ACM48430.1
EMBL· GenBank· DDBJ
Genomic DNA
FJ015235
EMBL· GenBank· DDBJ
ACM48432.1
EMBL· GenBank· DDBJ
Genomic DNA
FJ015237
EMBL· GenBank· DDBJ
ACM48434.1
EMBL· GenBank· DDBJ
Genomic DNA
FJ015238
EMBL· GenBank· DDBJ
ACM48435.1
EMBL· GenBank· DDBJ
Genomic DNA
FJ015239
EMBL· GenBank· DDBJ
ACM48436.1
EMBL· GenBank· DDBJ
Genomic DNA
FJ015240
EMBL· GenBank· DDBJ
ACM48437.1
EMBL· GenBank· DDBJ
Genomic DNA
FJ015241
EMBL· GenBank· DDBJ
ACM48438.1
EMBL· GenBank· DDBJ
Genomic DNA
FJ015243
EMBL· GenBank· DDBJ
ACM48440.1
EMBL· GenBank· DDBJ
Genomic DNA
FJ015244
EMBL· GenBank· DDBJ
ACM48441.1
EMBL· GenBank· DDBJ
Genomic DNA
FJ015245
EMBL· GenBank· DDBJ
ACM48442.1
EMBL· GenBank· DDBJ
Genomic DNA
FJ015246
EMBL· GenBank· DDBJ
ACM48443.1
EMBL· GenBank· DDBJ
Genomic DNA
FJ015247
EMBL· GenBank· DDBJ
ACM48444.1
EMBL· GenBank· DDBJ
Genomic DNA
FJ015249
EMBL· GenBank· DDBJ
ACM48446.1
EMBL· GenBank· DDBJ
Genomic DNA
FJ015250
EMBL· GenBank· DDBJ
ACM48447.1
EMBL· GenBank· DDBJ
Genomic DNA
FJ015251
EMBL· GenBank· DDBJ
ACM48448.1
EMBL· GenBank· DDBJ
Genomic DNA
FJ015252
EMBL· GenBank· DDBJ
ACM48449.1
EMBL· GenBank· DDBJ
Genomic DNA
FJ015254
EMBL· GenBank· DDBJ
ACM48451.1
EMBL· GenBank· DDBJ
Genomic DNA
FJ015256
EMBL· GenBank· DDBJ
ACM48453.1
EMBL· GenBank· DDBJ
Genomic DNA
FJ015257
EMBL· GenBank· DDBJ
ACM48454.1
EMBL· GenBank· DDBJ
Genomic DNA
FJ015258
EMBL· GenBank· DDBJ
ACM48455.1
EMBL· GenBank· DDBJ
Genomic DNA
FJ015259
EMBL· GenBank· DDBJ
ACM48456.1
EMBL· GenBank· DDBJ
Genomic DNA
FJ015260
EMBL· GenBank· DDBJ
ACM48457.1
EMBL· GenBank· DDBJ
Genomic DNA
FJ015261
EMBL· GenBank· DDBJ
ACM48458.1
EMBL· GenBank· DDBJ
Genomic DNA
FJ015262
EMBL· GenBank· DDBJ
ACM48459.1
EMBL· GenBank· DDBJ
Genomic DNA
FJ015263
EMBL· GenBank· DDBJ
ACM48460.1
EMBL· GenBank· DDBJ
Genomic DNA
FJ015264
EMBL· GenBank· DDBJ
ACM48461.1
EMBL· GenBank· DDBJ
Genomic DNA
FJ015265
EMBL· GenBank· DDBJ
ACM48462.1
EMBL· GenBank· DDBJ
Genomic DNA
FJ015266
EMBL· GenBank· DDBJ
ACM48463.1
EMBL· GenBank· DDBJ
Genomic DNA
FJ015267
EMBL· GenBank· DDBJ
ACM48464.1
EMBL· GenBank· DDBJ
Genomic DNA
FJ015268
EMBL· GenBank· DDBJ
ACM48465.1
EMBL· GenBank· DDBJ
Genomic DNA
FJ015269
EMBL· GenBank· DDBJ
ACM48466.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

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