Genetic polymorphisms in the opioid receptor delta 1 (OPRD1) gene are associated with methadone dose in methadone maintenance treatment for heroin dependence.
Genotype distribution and allelic frequency analyses showed that the minor C allele of rs2234918 in OPRD1 is over-represented in the heroin dependence (HD) group. C allele carriers have a 1.42 times greater risk for HD compared to T/T homozygotes. OPRD1 gene may not only play a role in the pathogenesis of HD but also affect the response to life stress among patients with HD in our Han Chinese population.
During prolonged hypoxia/ischemia delta-opioid receptor (DOR) neuroprotection involves a variety of signaling pathways. The data suggest that DOR may display its neuroprotective role via the BDNF-TrkB pathway. (review)
Site-specific O-glycosylation of N-terminal serine residues by polypeptide GalNAc-transferase 2 modulates human delta-opioid receptor turnover at the plasma membrane.
Results from the present study suggest that in patients with hip osteoarthritis genetic variants in OPRM1 and OPRD1 may contribute to the pain phenotype.
Homozygotes AA at rs6265 (BDNF) TT at rs16917234 (BDNF) and CC at rs508448 (OPRD1) also appeared as risk factors for the endophenotype earlier age of onset for heroin use.
Functional activity of Dynorphin 1-17 and fragments (1-6 1-7 and 1-9) were screened over a range of concentrations against forskolin stimulated human embryonic kidney 293 (HEK) cells stably transfected with one of KOP MOP or DOP
A polymorphism in OPRD1 appears to be associated with both cocaine dependence and cocaine use during treatment in African-Americans. Follow-up studies to confirm the effect on cocaine use are warranted.
The study successfully developed a population PKPD model for oxycodone across three experimental pain types and investigated the association between 18 SNPs across all three opioid receptor genes (OPRM1 OPRK1 OPRD1) and analgesic response from oxycodone. None of the selected polymorphisms were significantly associated with analgesic response of oxycodone.
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