D2AA19 · PAGP_SHIF2
- ProteinLipid A acyltransferase PagP
- GenepagP
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids186 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Transfers a fatty acid residue from the sn-1 position of a phospholipid to the N-linked hydroxyfatty acid chain on the proximal unit of lipid A or its precursors.
Catalytic activity
- a lipid A + a 1,2-diacyl-sn-glycero-3-phosphocholine = a hepta-acyl lipid A + a 2-acyl-sn-glycero-3-phosphocholine
Features
Showing features for active site, site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Active site | 58 | |||||
Sequence: H | ||||||
Site | 67 | Role in lipopolysaccharide recognition | ||||
Sequence: K | ||||||
Active site | 101 | |||||
Sequence: D | ||||||
Active site | 102 | |||||
Sequence: S | ||||||
Site | 172 | Role in the phospholipid gating | ||||
Sequence: Y |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cell outer membrane | |
Molecular Function | acyltransferase activity | |
Biological Process | lipid A biosynthetic process |
Keywords
- Molecular function
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameLipid A acyltransferase PagP
- EC number
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageBacteria > Pseudomonadota > Gammaproteobacteria > Enterobacterales > Enterobacteriaceae > Shigella
Accessions
- Primary accessionD2AA19
Proteomes
Subcellular Location
PTM/Processing
Features
Showing features for signal, chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Signal | 1-25 | |||||
Sequence: MNVSKYVAIFSFVFIQLISVGKVFA | ||||||
Chain | PRO_0000414477 | 26-186 | Lipid A acyltransferase PagP | |||
Sequence: NADERMTTFRENIAQTWQQPEHYDLYIPAITWHARFAYDKEKTDRYNERPWGGGFGLSRWDEKGNWHGLYAMAFKDSWNKWEPIAGYGWESTWRPLADENFHLGLGFTAGVTARDNWNYIPLPVLLPLASVGYGPVTFQMTYIPGTYNNGNVYFAWMRFQF |
Interaction
Subunit
Homodimer.
Structure
Sequence
- Sequence statusComplete
- Sequence processingThe displayed sequence is further processed into a mature form.
- Length186
- Mass (Da)21,740
- Last updated2011-12-14 v2
- Checksum3BB35C055A4F6487
Sequence caution
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
CP001383 EMBL· GenBank· DDBJ | ADA73024.1 EMBL· GenBank· DDBJ | Genomic DNA | Different initiation |