D1MIA2 · D1MIA2_DANRE

Function

function

Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.

Catalytic activity

Cofactor

Protein has several cofactor binding sites:
Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Mn2+ (UniProtKB | Rhea| CHEBI:29035 )

Note: Binds 2 magnesium ions per subunit. Is also active with manganese (in vitro).
Mn2+ (UniProtKB | Rhea| CHEBI:29035 )

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site301Mg2+ 2 (UniProtKB | ChEBI); catalytic
Binding site301Mg2+ 1 (UniProtKB | ChEBI); catalytic
Binding site301-306ATP (UniProtKB | ChEBI)
Binding site302Mg2+ 2 (UniProtKB | ChEBI); catalytic
Binding site343-345ATP (UniProtKB | ChEBI)
Binding site345Mg2+ 2 (UniProtKB | ChEBI); catalytic
Binding site345Mg2+ 1 (UniProtKB | ChEBI); catalytic
Binding site389ATP (UniProtKB | ChEBI)
Binding site913ATP (UniProtKB | ChEBI)
Binding site990-992ATP (UniProtKB | ChEBI)
Binding site997-1001ATP (UniProtKB | ChEBI)
Binding site1036ATP (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentplasma membrane
Molecular Functionadenylate cyclase activity
Molecular FunctionATP binding
Molecular Functionmetal ion binding
Biological Processadenylate cyclase-activating G protein-coupled receptor signaling pathway
Biological ProcesscAMP biosynthetic process
Biological Processintracellular signal transduction

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    adenylate cyclase
  • EC number

Gene names

    • Name
      adcy1a
    • Synonyms
      ADCY1a
      , si:dkey-162m2.1

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Actinopterygii > Neopterygii > Teleostei > Ostariophysi > Cypriniformes > Danionidae > Danioninae > Danio

Accessions

  • Primary accession
    D1MIA2

Proteomes

Organism-specific databases

Subcellular Location

Membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane52-74Helical
Transmembrane86-104Helical
Transmembrane116-135Helical
Transmembrane155-170Helical
Transmembrane177-197Helical
Transmembrane203-224Helical
Transmembrane601-623Helical
Transmembrane629-650Helical
Transmembrane671-692Helical
Transmembrane718-738Helical
Transmembrane745-764Helical

Keywords

  • Cellular component

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain296-423Guanylate cyclase
Domain861-1003Guanylate cyclase

Sequence similarities

Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    1,114
  • Mass (Da)
    124,626
  • Last updated
    2010-01-19 v1
  • Checksum
    2539D429A23FC0C8
MNGPAMEEVPLPRVRTRRRKSRCLAGACERDFDCKELETLFQKYNLKLEQTATLKALAILILAASALALVELLSAGSRFTVSKGSHPVHCVIFTSLFIVTNVKYLQVTQLQQIARLALLFSFTFALLCCPFPLALGHGTQGTHGPDAPSTTPEQGVWQLMLVTFVAYSLLPVRTLLAVLFGVLVAASHFIVTATSVTARRPRVWTPLVANAVLLVGVNLSGVFVRVRTERAQRKAFLQARNCIQQRLQLEDENEKQERLLMSLLPRNVAMEMKEDFLKPPERIFHKIYIQRHDNVSILFADIVGFTSLASQCTAQELVKLLNELFGKFDELATENHCRRIKILGDCYYCVSGLTQPKADHAHCCVEMGLDMIDTITSVAEATEVDLNMRVGLHTGRVLCGVLGLRKWQYDVWSNDVTLANMMEAGGLPGKVHITKATLECLNGDYEVEPGFGHERHAFLSKHAIETFFIVPSHRRKIFPGLILSDIKPAKRMEFKTVCYLLVQLMHCRKMFKAEIPFSNVMTCEDDDKRRALRTASEKLRNRTSFSAGMVQNSPGTRVNRYIGRLIEARQTESEMADLNYITLTYRSREREQRYLQVYDDAFISAVVISLVLTSFFAVVYFLIIPQGLLVVILLVLCLCFHMASVMYLHVTHVQCSPDCLTLQIRTVLCGFLVLLMYSVTQGCVVTCVPWSLEGNSSISMVTVVTVNGTGVGYRVCKYTPYVFLSCVMASLSVALYLRVSSLPKILLLLLLNILHTVVMETSGYRKAVGGGFFHTHGYDPVLAMLLFSGALVLHCRQLDLKLRLDYLWATQAEEERDDMERVKLDNKRILFNLLPAHVAQHFLLSNPRNMDLYYQSYSQVGVLFASIPNFNDFYIELDGNNMGVECLRLLNEIIADFDALMDKECYRDIEKIKTIGSTYMAAVGLVPTEGSKVKKSISAHLCTVADYAIEMFDVLDAINYQSYNDFVLRVGINVGPVVAGVIGARRPQYDIWGNTVNVASRMDSTGVQGKIQVTEDVFRLLSGYYDFNCRGQVSVKGKGQMLTYFLEGRTPQGAQHSRSKSPDQDSSPCIRTKLGSAPAVSSYGVKSHTVGHVGTSNNSILYLPSVSVDMEMEV

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
GU169394
EMBL· GenBank· DDBJ
ACZ48694.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

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