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D1MCB5 · D1MCB5_HETFO

Function

function

Hydrolyzes glucose-6-phosphate to glucose in the endoplasmic reticulum. Forms with the glucose-6-phosphate transporter (SLC37A4/G6PT) the complex responsible for glucose production in the terminal step of glycogenolysis and gluconeogenesis. Hence, it is the key enzyme in homeostatic regulation of blood glucose levels.

Catalytic activity

Pathway

Carbohydrate biosynthesis; gluconeogenesis.

Features

Showing features for binding site, active site.

131720406080100120140160180200220240260280300
Type
IDPosition(s)Description
Binding site83substrate
Active site119Proton donor
Binding site171substrate
Active site177Nucleophile

GO annotations

AspectTerm
Cellular Componentendoplasmic reticulum membrane
Molecular Functionglucose-6-phosphatase activity
Biological Processgluconeogenesis
Biological Processglucose 6-phosphate metabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Glucose-6-phosphatase catalytic subunit 1
  • EC number
  • Alternative names
    • Glucose-6-phosphatase

Gene names

    • Name
      g6pc

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Actinopterygii > Neopterygii > Teleostei > Ostariophysi > Siluriformes > Heteropneustidae > Heteropneustes

Accessions

  • Primary accession
    D1MCB5

Subcellular Location

Endoplasmic reticulum membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane29-51Helical
Transmembrane120-139Helical
Transmembrane151-172Helical
Transmembrane178-197Helical
Transmembrane209-228Helical
Transmembrane290-307Helical

Keywords

PTM/Processing

Keywords

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain57-197Phosphatidic acid phosphatase type 2/haloperoxidase

Sequence similarities

Belongs to the glucose-6-phosphatase family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Fragment
  • Length
    317
  • Mass (Da)
    36,045
  • Last updated
    2013-10-16 v2
  • MD5 Checksum
    CE731D4DDA5D0E9B393D575D9F0DCC32
MEEVMDKMHGYGVTATQYLQTNYKDAQGWFLFVSFAADLRNTFFIFFPIWFHFRPSVGIKLIWVAVVGNWHNGDLKWILFGERPYWWVHETPYYSNTSVPHIEQFPMTCETGPGSPSGHAMGAAGVYYAMVTSILTIMLSRKTTCPTKALYLRVTLWTLFWTVQICVCLSRVFLAAHFPHQVIAGVITGMIVAEVFNRQRWIYYASLQRYFNITLFLLAFAVGFYVLLKAVGVDLLWTLEKAQTWCVNPAWVHLDTTPFASLLRNMGPLFGLGLGLHSPLYTDSMMGSKAFVRIGCVLGSLLLLHLFDSIKPPTHTA

Features

Showing features for non-terminal residue.

TypeIDPosition(s)Description
Non-terminal residue317

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
GU131155
EMBL· GenBank· DDBJ
ACY78417.2
EMBL· GenBank· DDBJ
mRNA

Similar Proteins

Disclaimer

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