D1MCB5 · D1MCB5_HETFO
- ProteinGlucose-6-phosphatase catalytic subunit 1
- Geneg6pc
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids317 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score3/5
Function
function
Hydrolyzes glucose-6-phosphate to glucose in the endoplasmic reticulum. Forms with the glucose-6-phosphate transporter (SLC37A4/G6PT) the complex responsible for glucose production in the terminal step of glycogenolysis and gluconeogenesis. Hence, it is the key enzyme in homeostatic regulation of blood glucose levels.
Catalytic activity
- D-glucose 6-phosphate + H2O = D-glucose + phosphate
Pathway
Carbohydrate biosynthesis; gluconeogenesis.
Features
Showing features for binding site, active site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 83 | substrate | |||
Active site | 119 | Proton donor | |||
Binding site | 171 | substrate | |||
Active site | 177 | Nucleophile | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | endoplasmic reticulum membrane | |
Molecular Function | glucose-6-phosphatase activity | |
Biological Process | gluconeogenesis | |
Biological Process | glucose 6-phosphate metabolic process |
Keywords
- Molecular function
- Biological process
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameGlucose-6-phosphatase catalytic subunit 1
- EC number
- Alternative names
Gene names
Organism names
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Actinopterygii > Neopterygii > Teleostei > Ostariophysi > Siluriformes > Heteropneustidae > Heteropneustes
Accessions
- Primary accessionD1MCB5
Subcellular Location
UniProt Annotation
GO Annotation
Endoplasmic reticulum membrane ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Transmembrane | 29-51 | Helical | |||
Transmembrane | 120-139 | Helical | |||
Transmembrane | 151-172 | Helical | |||
Transmembrane | 178-197 | Helical | |||
Transmembrane | 209-228 | Helical | |||
Transmembrane | 290-307 | Helical | |||
Keywords
- Cellular component
PTM/Processing
Keywords
- PTM
Structure
Family & Domains
Sequence
- Sequence statusFragment
- Length317
- Mass (Da)36,045
- Last updated2013-10-16 v2
- MD5 ChecksumCE731D4DDA5D0E9B393D575D9F0DCC32
Features
Showing features for non-terminal residue.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Non-terminal residue | 317 | ||||
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
GU131155 EMBL· GenBank· DDBJ | ACY78417.2 EMBL· GenBank· DDBJ | mRNA |