D1L2W4 · TUBE1_BPK32

Function

function

Structural component of the tail, which functions as a receptor binding protein (RBP) and mediates the attachment to the host capsular exopolysaccharides (PubMed:28533535).
Displays a depolymerase activity that specifically degrades the polysaccharides of Klebsiella pneumoniae capsule, which allows the phage to reach the host cell membrane and bind the entry receptor (PubMed:28533535).
Hydrolyzes maltose (PubMed:29273737).
Does not hydrolyze alpha-lactose, beta-lactose, trehalose, melibiose, cellobiose (PubMed:29273737).
Displays amylase activity (PubMed:29273737).

pH Dependence

Optimum pH is 5.5-6.0.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentvirion component
Molecular Functionhydrolase activity, acting on glycosyl bonds
Biological Processadhesion receptor-mediated virion attachment to host cell
Biological Processsymbiont entry into host cell via disruption of host cell envelope
Biological Processsymbiont entry into host cell via disruption of host cell glycocalyx

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Tail tubular protein A
  • Short names
    TTPA
  • Alternative names
    • Depolymerase
      (EC:3.2.1.-
      ) . EC:3.2.1.- (UniProtKB | ENZYME | Rhea)
    • Gene product 31
      (gp31
      )

Gene names

    • Name
      31

Organism names

Accessions

  • Primary accession
    D1L2W4

Proteomes

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00004587301-192Tail tubular protein A

Interaction

Subunit

Homotetramer.

Structure

Family & Domains

Sequence similarities

Belongs to the tail tubular protein gp11 family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    192
  • Mass (Da)
    21,375
  • Last updated
    2010-01-19 v1
  • Checksum
    D6DD559907EB6F7E
MNMQDAYFGSAAELDAVNEMLAAIGESPVTTLDEDGSADVANARRILNRINRQIQSKGWAFNINESATLTPDVSTGLIPFRPAYLSILGGQYVNRGGWVYDKSTGTDTFSGPITVTLITLQDYDEMPECFRQWIVTKASRQFNSRFFGAEDVENSLAQEEMEARMACNEYEMDFGQYNMLDGDAYVQGLIGR

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
GQ413937
EMBL· GenBank· DDBJ
ACY66693.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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