D1KBH2 · D1KBH2_9GAMM

Function

function

Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.

Cofactor

Zn2+ (UniProtKB | Rhea| CHEBI:29105 )

Note: Binds 1 zinc ion per subunit.

Features

Showing features for binding site, active site.

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Type
IDPosition(s)Description
Binding site191-198ATP (UniProtKB | ChEBI)
Binding site413Zn2+ (UniProtKB | ChEBI); catalytic
Active site414
Binding site417Zn2+ (UniProtKB | ChEBI); catalytic
Binding site491Zn2+ (UniProtKB | ChEBI); catalytic

GO annotations

AspectTerm
Cellular Componentplasma membrane
Molecular FunctionATP binding
Molecular FunctionATP hydrolysis activity
Molecular FunctionATP-dependent peptidase activity
Molecular Functionmetalloendopeptidase activity
Molecular Functionzinc ion binding
Biological Processprotein catabolic process
Biological Processproteolysis

Keywords

Enzyme and pathway databases

Protein family/group databases

Names & Taxonomy

Protein names

  • Recommended name
    ATP-dependent zinc metalloprotease FtsH
  • EC number

Gene names

    • Name
      ftsH
    • ORF names
      Sup05_0050

Organism names

Accessions

  • Primary accession
    D1KBH2

Proteomes

Subcellular Location

Cell membrane
; Multi-pass membrane protein
Membrane

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane100-118Helical

Keywords

Interaction

Subunit

Homohexamer.

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain, region.

Type
IDPosition(s)Description
Domain183-322AAA+ ATPase
Region612-641Disordered

Sequence similarities

Belongs to the AAA ATPase family.
In the C-terminal section; belongs to the peptidase M41 family.
In the central section; belongs to the AAA ATPase family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    641
  • Mass (Da)
    69,119
  • Last updated
    2010-01-19 v1
  • Checksum
    BE809D5BC389BB3F
MVKNLLLWLVLGSVLTSIFSQFQLSEQKNDVTYSQFIQSVKQGDVSQVTIAGSHIKGVGAGGEEFSTYSPGDLGLMGDLLDNGVNVIAKPPEQEGFFKQLIISLAPILLLIGVILYTMKGAGGAMGGKNPMSFGKSKARLITKDESNVTFKDVAGVDEAKAEVMELVDFLSDPGKFTKVGGKIPKGVLMVGPPGTGKTLLAKAIAGEADVPFFFISGSDFVEMFVGVGASRVRDMFEQAKKSAPCIIFIDEIDAVGRQRGAGMGGGHDEREQTLNQMLVEMDGFEGNEGIIVIAATNRPDVLDPALLRPGRFDRQVTVGLPDINGRDAILKVHMRKLPIAKNVKSINIAKGTPGFSGADLANLANEAALIAAGKGKDLVGMQEFEKAKDKIMMGSERKSMVMDEAEKEMTAYHEAGHAIVGRLVPEHDPVYKVSIIPRGRALGVTMFLPEKDSYSISKRKLNSQVSSLFGGRIAEELIYGTDSVTTGASNDIERATEIAHKMVKHWGMSKALGPLAYGEDDGEVFLGRQVTKHKHISDKTFDLIDIEIRKIIDVNYDIAYKILEENKDILHAMAKSLIEIETIDKDQIDDLMNRKPMREAAVIIDSDVASTELGSGVDVPKDTSSDSDEKPLGGSGTQQTA

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
GG729979
EMBL· GenBank· DDBJ
EEZ80515.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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