D1CD51 · D1CD51_THET1

Function

function

Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions.

Catalytic activity

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Note: Binds 1 Mg2+ ion per subunit.

Features

Showing features for binding site, active site.

Type
IDPosition(s)Description
Binding site10-15substrate
Binding site43Mg2+ (UniProtKB | ChEBI)
Active site72Proton acceptor
Binding site72Mg2+ (UniProtKB | ChEBI)
Binding site73substrate
Binding site155-158substrate
Binding site178substrate
Binding site183-184substrate

GO annotations

AspectTerm
Cellular Componentcytosol
Molecular FunctiondITP diphosphatase activity
Molecular FunctionITP diphosphatase activity
Molecular Functionmetal ion binding
Molecular Functionnucleotide binding
Molecular Functionribonucleoside triphosphate phosphatase activity
Molecular FunctionXTP diphosphatase activity
Biological Processnucleotide metabolic process
Biological Processpurine nucleoside triphosphate catabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    dITP/XTP pyrophosphatase
  • EC number
  • Alternative names
    • Non-canonical purine NTP pyrophosphatase
    • Non-standard purine NTP pyrophosphatase
    • Nucleoside-triphosphate diphosphatase
    • Nucleoside-triphosphate pyrophosphatase
      (NTPase
      )

Gene names

    • Ordered locus names
      Tter_1810

Organism names

Accessions

  • Primary accession
    D1CD51

Proteomes

Subcellular Location

Interaction

Subunit

Homodimer.

Protein-protein interaction databases

Family & Domains

Sequence similarities

Belongs to the HAM1 NTPase family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    202
  • Mass (Da)
    22,403
  • Last updated
    2010-01-19 v1
  • Checksum
    02A832DD1806E3B8
MKLSKLLIASDNPGKLAEYQELLSGLGIEIVSMRDAGIERAPEETGSTFEENALIKARYCWNMTGISSIADDSGLEVAALGGEPGVRSKRWAGEQISDAERNKLLIERLNKASSSNKSARFVCVIALIDRYGNEHLFRGEVEGVIIDHPRGSHGFGYDPIFYLPELGKTFAELDMLEKNRVSHRARAAQLAVDWIKRNLDKL

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP001825
EMBL· GenBank· DDBJ
ACZ42716.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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