D1CBW4 · D1CBW4_THET1
- ProteinDihydroorotase
- GenepyrC
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids448 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate.
Catalytic activity
- (S)-dihydroorotate + H2O = N-carbamoyl-L-aspartate + H+
Cofactor
Note: Binds 2 Zn2+ ions per subunit.
Pathway
Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 3/3.
Features
Showing features for binding site, active site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 63 | Zn2+ 1 (UniProtKB | ChEBI) | |||
Binding site | 65 | Zn2+ 1 (UniProtKB | ChEBI) | |||
Binding site | 65-67 | substrate | |||
Binding site | 97 | substrate | |||
Binding site | 154 | Zn2+ 1 (UniProtKB | ChEBI) | |||
Binding site | 154 | Zn2+ 2 (UniProtKB | ChEBI) | |||
Binding site | 181 | Zn2+ 2 (UniProtKB | ChEBI) | |||
Binding site | 234 | Zn2+ 2 (UniProtKB | ChEBI) | |||
Binding site | 294 | substrate | |||
Active site | 321 | ||||
Binding site | 321 | Zn2+ 1 (UniProtKB | ChEBI) | |||
Binding site | 325 | substrate | |||
Binding site | 339-340 | substrate | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Molecular Function | allantoinase activity | |
Molecular Function | dihydroorotase activity | |
Molecular Function | zinc ion binding | |
Biological Process | 'de novo' UMP biosynthetic process | |
Biological Process | purine nucleobase catabolic process |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameDihydroorotase
- EC number
- Short namesDHOase
Gene names
Organism names
- Strain
- Taxonomic lineageBacteria > Chloroflexota > Thermobaculum
Accessions
- Primary accessionD1CBW4
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Interaction
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Domain | 55-430 | Amidohydrolase-related | |||
Sequence similarities
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length448
- Mass (Da)48,008
- Last updated2010-01-19 v1
- MD5 Checksum45036D74722F048E222835535A40851E
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
CP001825 EMBL· GenBank· DDBJ | ACZ42279.1 EMBL· GenBank· DDBJ | Genomic DNA |