D1CBW4 · D1CBW4_THET1

Function

function

Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate.

Catalytic activity

Cofactor

Zn2+ (UniProtKB | Rhea| CHEBI:29105 )

Note: Binds 2 Zn2+ ions per subunit.

Pathway

Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 3/3.

Features

Showing features for binding site, active site.

144850100150200250300350400
Type
IDPosition(s)Description
Binding site63Zn2+ 1 (UniProtKB | ChEBI)
Binding site65Zn2+ 1 (UniProtKB | ChEBI)
Binding site65-67substrate
Binding site97substrate
Binding site154Zn2+ 1 (UniProtKB | ChEBI)
Binding site154Zn2+ 2 (UniProtKB | ChEBI)
Binding site181Zn2+ 2 (UniProtKB | ChEBI)
Binding site234Zn2+ 2 (UniProtKB | ChEBI)
Binding site294substrate
Active site321
Binding site321Zn2+ 1 (UniProtKB | ChEBI)
Binding site325substrate
Binding site339-340substrate

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular Functionallantoinase activity
Molecular Functiondihydroorotase activity
Molecular Functionzinc ion binding
Biological Process'de novo' UMP biosynthetic process
Biological Processpurine nucleobase catabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Dihydroorotase
  • EC number
  • Short names
    DHOase

Gene names

    • Name
      pyrC
    • Ordered locus names
      Tter_1372

Organism names

Accessions

  • Primary accession
    D1CBW4

Proteomes

Subcellular Location

Interaction

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain55-430Amidohydrolase-related

Sequence similarities

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    448
  • Mass (Da)
    48,008
  • Last updated
    2010-01-19 v1
  • MD5 Checksum
    45036D74722F048E222835535A40851E
MSRLLLSGARIVCPYTSIDSTGDVLIEDGRVAAVCIGKSLDVDQAESVDCKGLVLSPAFVDVHVHLREPGEEHKETIASGASAALAGGFTTICAMPNTNPAIDNSRLVRWVIDRANGTGIRVLPIGAITIARQGKVPVDYEAMVKAGAVAFSDDGSPVMNSRMMRLALLYSRTLGVPISSHCEDTELSAKGCMHDGAVSARLGLPGIPASAEEAMIYRDLSLAAETGGHIHIAHVSTSGGVEAIRHAKKIGVRVTAEATPHHFTFTDEWVAGWRDSSTDRCLSISAYDTNAKVNPPLRSREHVEAVIDGLVDGTIDAIATDHAPHSVLEKDCPFEEAAFGISGLETALPLSLELVRTGRISMMKMVSLLTISPAKAFGIDHWGIEEGRDANLVLFDPNLKWTVTPSALLSKGKNTPLIGRQVMGRVLMTISGNKRYVREELKAKWKQH

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP001825
EMBL· GenBank· DDBJ
ACZ42279.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

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