D1CBD4 · D1CBD4_THET1

Function

function

Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine.

Catalytic activity

Cofactor

Protein has several cofactor binding sites:
Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Note: Binds 1 Mg2+ ion per subunit.
[4Fe-4S] cluster (UniProtKB | Rhea| CHEBI:49883 )

Note: Binds 1 [4Fe-4S] cluster per subunit.

Pathway

Purine metabolism; IMP biosynthesis via de novo pathway; N1-(5-phospho-D-ribosyl)glycinamide from 5-phospho-alpha-D-ribose 1-diphosphate: step 1/2.

Features

Showing features for active site, binding site.

TypeIDPosition(s)Description
Active site20Nucleophile
Binding site254[4Fe-4S] cluster (UniProtKB | ChEBI)
Binding site302Mg2+ (UniProtKB | ChEBI)
Binding site364Mg2+ (UniProtKB | ChEBI)
Binding site365Mg2+ (UniProtKB | ChEBI)
Binding site401[4Fe-4S] cluster (UniProtKB | ChEBI)
Binding site461[4Fe-4S] cluster (UniProtKB | ChEBI)
Binding site464[4Fe-4S] cluster (UniProtKB | ChEBI)

GO annotations

AspectTerm
Molecular Function4 iron, 4 sulfur cluster binding
Molecular Functionamidophosphoribosyltransferase activity
Molecular Functionmagnesium ion binding
Biological Process'de novo' IMP biosynthetic process
Biological Processglutamine metabolic process
Biological Processpurine nucleobase biosynthetic process

Keywords

Enzyme and pathway databases

Protein family/group databases

Names & Taxonomy

Protein names

  • Recommended name
    Amidophosphoribosyltransferase
  • EC number
  • Short names
    ATase
  • Alternative names
    • Glutamine phosphoribosylpyrophosphate amidotransferase
      (GPATase
      )

Gene names

    • Name
      purF
    • Ordered locus names
      Tter_1191

Organism names

Accessions

  • Primary accession
    D1CBD4

Proteomes

Interaction

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain20-238Glutamine amidotransferase type-2

Sequence similarities

In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    485
  • Mass (Da)
    53,140
  • Last updated
    2010-01-19 v1
  • Checksum
    9DA01C3318A0CE71
MLCKPVDYNLLQMDALHEECGVIGIWQPREVFDTANYLVLGLTELQHRGQESAGIAVYDGNSIHTHIGMGKVREVFRDGPPPIQGKTGIGHVRYSTTGSSCVENAGPFLVGQHPLQMALAHNGNISNSEELKALMPDETFVSNTDSEVVARLIIRAPGSSLAEKLCSVVPMLRGAYSFVMLYDGKLYALRDPLGMRPLAFGKIGDAWILASESAAIEKLGGEYIRDVLPGELVEIGRDGVRSKIIASSDRHAFCVFEYIYFAGAATTIEGKYVYSVRQALGRKLAQEHPVFDADLVGGVPDSAIPAAIAYASECGLPYEEVFIKSRYAERSFIKPDQRLRRLEVDLKFSIVKPNVEDKKIVIVDDSIVRGNTMKRAVSALRRYGAKEVHLRITSPPLKHPCYYGIDIKSDEDLIAAHSTVQEIADYIGVDSLGYLSLQGLAEVITDKLGQEALSLFHATHCYGCFDAVGYPYSKLSPEPAYSSST

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP001825
EMBL· GenBank· DDBJ
ACZ42099.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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