D1CBD1 · D1CBD1_THET1

Function

function

Catalyzes the transfer of a methyl group from 5-methyltetrahydrofolate to homocysteine resulting in methionine formation.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.

Catalytic activity

Cofactor

Protein has several cofactor binding sites:
Zn2+ (UniProtKB | Rhea| CHEBI:29105 )

Note: Binds 1 zinc ion per subunit.
Zn2+ (UniProtKB | Rhea| CHEBI:29105 )

Note: Binds 2 Zn2+ ions per subunit.

Pathway

Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-methionine from L-homocysteine (MetE route): step 1/1.

Features

Showing features for binding site, active site.

TypeIDPosition(s)Description
Binding site16-195-methyltetrahydropteroyltri-L-glutamate (UniProtKB | ChEBI)
Binding site195-methyltetrahydropteroyltri-L-glutamate (UniProtKB | ChEBI)
Binding site1155-methyltetrahydropteroyltri-L-glutamate (UniProtKB | ChEBI)
Binding site1205-methyltetrahydropteroyltri-L-glutamate (UniProtKB | ChEBI)
Binding site439-441L-homocysteine (UniProtKB | ChEBI)
Binding site439-441L-methionine (UniProtKB | ChEBI)
Binding site492L-homocysteine (UniProtKB | ChEBI)
Binding site492L-methionine (UniProtKB | ChEBI)
Binding site5695-methyltetrahydropteroyltri-L-glutamate (UniProtKB | ChEBI)
Binding site607L-homocysteine (UniProtKB | ChEBI)
Binding site607L-methionine (UniProtKB | ChEBI)
Binding site6135-methyltetrahydropteroyltri-L-glutamate (UniProtKB | ChEBI)
Binding site649Zn2+ 1 (UniProtKB | ChEBI); catalytic
Binding site649Zn2+ (UniProtKB | ChEBI); catalytic
Binding site651Zn2+ 1 (UniProtKB | ChEBI); catalytic
Binding site651Zn2+ (UniProtKB | ChEBI); catalytic
Binding site664Zn2+ 1 (UniProtKB | ChEBI); catalytic
Binding site673Zn2+ (UniProtKB | ChEBI); catalytic
Binding site673Zn2+ 1 (UniProtKB | ChEBI); catalytic
Active site702Proton donor
Binding site734Zn2+ 1 (UniProtKB | ChEBI); catalytic
Binding site734Zn2+ (UniProtKB | ChEBI); catalytic

GO annotations

AspectTerm
Molecular Function5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase activity
Molecular Functionzinc ion binding
Biological Processmethionine biosynthetic process
Biological Processmethylation

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase
  • EC number
  • Alternative names
    • Cobalamin-independent methionine synthase
    • Methionine synthase, vitamin-B12 independent isozyme

Gene names

    • Name
      metE
    • Ordered locus names
      Tter_1188

Organism names

Accessions

  • Primary accession
    D1CBD1

Proteomes

Interaction

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain5-316Cobalamin-independent methionine synthase MetE N-terminal
Domain434-756Cobalamin-independent methionine synthase MetE C-terminal/archaeal

Sequence similarities

Belongs to the vitamin-B12 independent methionine synthase family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    767
  • Mass (Da)
    87,671
  • Last updated
    2010-01-19 v1
  • Checksum
    D0936C11619CBFCD
MALATIHGYPRIGKNRELKKALESYWAGKISKEDLLKTAKEIQVNNWQTQKSVGIDLIPSGDFSLYDHVLDTTALLGTIPPRFRHDTQSVDLDTYFAMARGRSGDKAANAMDMTKWFDTNYHYIVPELYPDQEFKLSSSKFYDDFQLAKDIGISTKPVLVGPATYLLLSRSEGGHFNPLLTLSDKITPIYIEVINQLANLGAEWIQLDEPVLVEDRTQEELDAIRRIYDRIASNTSIQIILSTYFGHLGDSYQQVVNLPVSAIGLDLVRGHQNLEYIRKLGFPQDKYLVAGVVDGRNVWTTDLHAKLEQLEFLATEVGSDKLMVSSSCSLLHVPIDVNLETHIDDELKSWLAFAEQKLEEIVLLRDGINLGRDAIKDKLEANAEVIQKRNASIRRFNPEVREKITSIKESDYTRYPDYKSRIETQRNTLPLPLLPTTTIGSFPQIPELRQIRRKFENGDISQQEYEGYLENKIRELIELQEDLGLDVFVHGEYERNDMVQYFGEQLDGFAFTRHGWVQSYGSRYVRPPIIYGDVNRPAPMTVRWITFAQSLTEKPVKGMLTGPVTILNWSFVRDDQPRSETCLQIARAIREEVLDLESAGIKIIQIDEPAIREGLPLRKSEWKEYLDWAVKCFRYSSSGVRPETQIHTHMCYSEFGDIIEAISDMDADVLYIENARSDLEMLEVFRQHGYDKGVGPGVYDVHSPRVPTVEEMADNIRATLTVLRPEQVWVNPDCGLKTRRPEEATPSLRNMVQAANQVREEMLSRIS

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP001825
EMBL· GenBank· DDBJ
ACZ42096.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

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