D1CB15 · D1CB15_THET1

Function

function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Catalytic activity

Pathway

One-carbon metabolism; tetrahydrofolate interconversion.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site169-171NADP+ (UniProtKB | ChEBI)
Binding site194NADP+ (UniProtKB | ChEBI)
Binding site235NADP+ (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytosol
Molecular Functionmethenyltetrahydrofolate cyclohydrolase activity
Molecular Functionmethylenetetrahydrofolate dehydrogenase (NADP+) activity
Biological ProcessL-histidine biosynthetic process
Biological Processmethionine biosynthetic process
Biological Processpurine nucleotide biosynthetic process
Biological Processtetrahydrofolate interconversion

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Bifunctional protein FolD

Including 2 domains:

  • Recommended name
    Methylenetetrahydrofolate dehydrogenase
  • EC number
  • Recommended name
    Methenyltetrahydrofolate cyclohydrolase
  • EC number

Gene names

    • Name
      folD
    • Ordered locus names
      Tter_1064

Organism names

Accessions

  • Primary accession
    D1CB15

Proteomes

Subcellular Location

Interaction

Subunit

Homodimer.

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain9-124Tetrahydrofolate dehydrogenase/cyclohydrolase catalytic
Domain127-282Tetrahydrofolate dehydrogenase/cyclohydrolase NAD(P)-binding

Sequence similarities

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    285
  • Mass (Da)
    30,568
  • Last updated
    2010-01-19 v1
  • Checksum
    35B32FA107AD96F6
MVNGPDNILDGKAVAKTIRQQLESQIQAFQTSRGYVPNLAVVLPSEEPDACLYAQNLQKWFQKLGLGCFVHQLSSSITQEDLCAYIRSLCSSADVHGVMIQMPLPDGVSYLSVAEALDPMKDVEGIHPYNFGLLSIGNPQVVPSTPMAAATLIDHYGIDVSGKNVVVIGRSNVVGKPFAQLMLMKHASVSVLHSRSKSIRDYTLNADIVAVAVGRPNTLTADMVREGVIVIDFGINFVNDRLVGDVDFEAVSPLASFITPVPGGIGPLTNLMLASNLIKLALTQP

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP001825
EMBL· GenBank· DDBJ
ACZ41980.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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