D0U4N0 · D0U4N0_9GAMM

Function

function

Catalyzes the NADPH-dependent formation of L-aspartate-semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl-4-phosphate.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.

Catalytic activity

Pathway

Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; (S)-tetrahydrodipicolinate from L-aspartate: step 2/4.
Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-homoserine from L-aspartate: step 2/3.
Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 2/5.

Features

Showing features for binding site, active site.

TypeIDPosition(s)Description
Binding site13-16NADP+ (UniProtKB | ChEBI)
Binding site41-42NADP+ (UniProtKB | ChEBI)
Binding site101phosphate (UniProtKB | ChEBI)
Active site132Acyl-thioester intermediate
Binding site159substrate
Binding site162-163NADP+ (UniProtKB | ChEBI)
Binding site239substrate
Active site246Proton acceptor
Binding site320NADP+ (UniProtKB | ChEBI)

GO annotations

AspectTerm
Molecular Functionaspartate-semialdehyde dehydrogenase activity
Molecular FunctionNAD binding
Molecular FunctionNADP binding
Molecular Functionprotein dimerization activity
Biological Process'de novo' L-methionine biosynthetic process
Biological Processdiaminopimelate biosynthetic process
Biological Processisoleucine biosynthetic process
Biological Processlysine biosynthetic process via diaminopimelate
Biological Processthreonine biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Aspartate-semialdehyde dehydrogenase
  • EC number
  • Short names
    ASA dehydrogenase
    ; ASADH
  • Alternative names
    • Aspartate-beta-semialdehyde dehydrogenase

Gene names

    • Name
      asd
    • ORF names
      Sup05_1334
      , SUP05_FGYC65E210007

Organism names

Accessions

  • Primary accession
    D0U4N0

Proteomes

Interaction

Subunit

Homodimer.

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain6-121Semialdehyde dehydrogenase NAD-binding

Sequence similarities

Belongs to the aspartate-semialdehyde dehydrogenase family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    341
  • Mass (Da)
    37,274
  • Last updated
    2009-12-15 v1
  • Checksum
    79A54BF5014C0711
MSKKYNVAVVGATGAVGETILSILEQRNFPIDNLYPLASANSAGKKVFCQGKSWTVQDLDTFDFSQAQIGLFSAGGNISEKYAPIAAEAGCVVIDNTAHFRRDEGIPLVVPEVNPHAISGYTKRNIIANPNCSTIQMLVALKPIYDAVGIERINVATYQAVSGSGKEAISELIEQTTKLLGGNTEVDVEVYPKQIAFNVIPHIDVFQDNGYTKEEMKMVWETQKIFEDDNILVNPTAVRVPVIYGHSEAINIETKTKITAAEAVEVLSKANGVTVLDKREDGGYATPFVEATNHDDTFVSRIREDISHEKGLNLWVVSDNIRKGAALNSIQIAEILIEEYL

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
GQ351269
EMBL· GenBank· DDBJ
ACX30562.1
EMBL· GenBank· DDBJ
Genomic DNA
GG730003
EMBL· GenBank· DDBJ
EEZ80090.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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