D0U4I6 · D0U4I6_9GAMM

Function

function

Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N2-acetylornithine and glutamate.

Miscellaneous

Some bacteria possess a monofunctional ArgJ, i.e., capable of catalyzing only the fifth step of the arginine biosynthetic pathway.

Catalytic activity

Pathway

Amino-acid biosynthesis; L-arginine biosynthesis; L-ornithine and N-acetyl-L-glutamate from L-glutamate and N2-acetyl-L-ornithine (cyclic): step 1/1.
Amino-acid biosynthesis; L-arginine biosynthesis; N2-acetyl-L-ornithine from L-glutamate: step 1/4.

Features

Showing features for site, binding site, active site.

TypeIDPosition(s)Description
Site109Involved in the stabilization of negative charge on the oxyanion by the formation of the oxyanion hole
Site110Involved in the stabilization of negative charge on the oxyanion by the formation of the oxyanion hole
Binding site146substrate
Binding site172substrate
Site182-183Cleavage; by autolysis
Active site183Nucleophile
Binding site183substrate
Binding site265substrate
Binding site389substrate
Binding site394substrate

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular Functionglutamate N-acetyltransferase activity
Molecular FunctionL-glutamate N-acetyltransferase activity
Biological Processarginine biosynthetic process
Biological Processornithine biosynthetic process

Keywords

Enzyme and pathway databases

Protein family/group databases

Names & Taxonomy

Protein names

Including 2 domains:

  • Recommended name
    Glutamate N-acetyltransferase
  • EC number
  • Alternative names
    • Ornithine acetyltransferase
      (OATase
      )
    • Ornithine transacetylase
  • Recommended name
    Amino-acid acetyltransferase
  • EC number
  • Alternative names
    • N-acetylglutamate synthase
      (AGSase
      )

Gene names

    • Name
      argJ
    • ORF names
      SUP05_FGYC13J70035

Organism names

Accessions

  • Primary accession
    D0U4I6

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_50235436791-182Arginine biosynthesis bifunctional protein ArgJ alpha chain
ChainPRO_5023543680183-394Arginine biosynthesis bifunctional protein ArgJ beta chain

Keywords

Interaction

Subunit

Heterotetramer of two alpha and two beta chains.

Family & Domains

Sequence similarities

Belongs to the ArgJ family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    394
  • Mass (Da)
    42,035
  • Last updated
    2009-12-15 v1
  • Checksum
    3311321E3D55C789
MSQSLLNIEGVLSASIDAGIKNNDATDLSIIYLTESTVTAAVFTQNVFCAAPVLVAKNHLNHHPKALLINSGNANAGTGSQGMENTLHTCACLAGELNINTEQVLPFSTGVIGQQLELDKFNQGIPKVVVKLSTDAMGDVAKGILTTDLVEKTASKQFEVNGKTVTISGIAKGSGMIRPDMATMLSFIFTDVESTQAKLQQCLTTSVNQSFNRITVDGDTSTNDACTLSATGASGVDIHDCVDEFQQALNEVTQSLAYQIIKDGEGATKFVEVCVKGGASSEDCLEVAYTVAHSPLVKTALFASDANWGRILAAVGRANISNLKIEDINIYLNEVSIIQAGEPDEHYTEEAGSNEMAKEEIIITIEIGKGDAQESVWTTDFSYDYVKINAEYRT

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
GQ351267
EMBL· GenBank· DDBJ
ACX30518.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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