D0R3H9 · D0R3H9_LACJF

Function

function

Catalyzes the reversible phosphorylation of UMP to UDP.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.

Catalytic activity

Activity regulation

Allosterically activated by GTP. Inhibited by UTP.

Pathway

Pyrimidine metabolism; CTP biosynthesis via de novo pathway; UDP from UMP (UMPK route): step 1/1.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site12-15ATP (UniProtKB | ChEBI)
Binding site54UMP (UniProtKB | ChEBI)
Binding site55ATP (UniProtKB | ChEBI)
Binding site59ATP (UniProtKB | ChEBI)
Binding site74UMP (UniProtKB | ChEBI)
Binding site135-142UMP (UniProtKB | ChEBI)
Binding site163ATP (UniProtKB | ChEBI)
Binding site169ATP (UniProtKB | ChEBI)
Binding site172ATP (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular FunctionATP binding
Molecular FunctionUMP kinase activity
Biological Process'de novo' CTP biosynthetic process
Biological Processphosphorylation
Biological ProcessUDP biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Uridylate kinase
  • EC number
  • Short names
    UK
  • Alternative names
    • Uridine monophosphate kinase
      (UMP kinase
      ; UMPK
      )

Gene names

    • Name
      pyrH
    • Ordered locus names
      FI9785_768

Organism names

Accessions

  • Primary accession
    D0R3H9

Proteomes

Subcellular Location

Keywords

Interaction

Subunit

Homohexamer.

Family & Domains

Features

Showing features for domain, region.

Type
IDPosition(s)Description
Domain7-217Aspartate/glutamate/uridylate kinase
Region20-25Involved in allosteric activation by GTP

Sequence similarities

Belongs to the UMP kinase family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    241
  • Mass (Da)
    25,931
  • Last updated
    2009-12-15 v1
  • MD5 Checksum
    BBC6D9019F925CFEDDF7A91C24E9239D
MSQVKYKRIILKVSGEALAGEKGTGINPEVIKHLAEEIKSVHDMGVEIGIVCGGGNMWRGETGANLGMERAQADYMGMLATIMNGLALQDGLENLGVPTRVQTSIEMRQIAEPYIRRKAIRHLEKGRVVIFGGGTGNPYFSTDTTAALRAAEINADVILMAKNGVDGVYSADPKVDPNAKKYSELTQLDLISKNLKVMDSTASSLSMDNNIPLVVFNVNKPGNIKKVVMGENIGTVIKGDK

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
FN298497
EMBL· GenBank· DDBJ
CAX66642.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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