D0L235 · D0L235_HALNC

Function

function

Cell wall formation. Synthesis of cross-linked peptidoglycan from the lipid intermediates. The enzyme has a penicillin-insensitive transglycosylase N-terminal domain (formation of linear glycan strands) and a penicillin-sensitive transpeptidase C-terminal domain (cross-linking of the peptide subunits).

Catalytic activity

Pathway

Cell wall biogenesis; peptidoglycan biosynthesis.

GO annotations

AspectTerm
Cellular Componentplasma membrane
Molecular Functionpenicillin binding
Molecular Functionpeptidoglycan glycosyltransferase activity
Molecular Functionserine-type D-Ala-D-Ala carboxypeptidase activity
Biological Processpeptidoglycan biosynthetic process
Biological Processproteolysis
Biological Processresponse to antibiotic

Keywords

Enzyme and pathway databases

Protein family/group databases

Names & Taxonomy

Protein names

  • Recommended name
    Penicillin-binding protein 1A
  • EC number

Gene names

    • Ordered locus names
      Hneap_1936

Organism names

Accessions

  • Primary accession
    D0L235

Proteomes

Subcellular Location

Cell inner membrane
; Single-pass type II membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane7-29Helical

Keywords

Interaction

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain55-229Glycosyl transferase family 51
Domain317-423Penicillin-binding protein OB-like
Domain427-683Penicillin-binding protein transpeptidase

Sequence similarities

In the C-terminal section; belongs to the transpeptidase family.
In the N-terminal section; belongs to the glycosyltransferase 51 family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    790
  • Mass (Da)
    86,138
  • Last updated
    2009-12-15 v1
  • Checksum
    55C852FA433108EE
MKLIKFVVYVFGFLLIFSVGGVGILYQIYNNQLPDVQDLAAVQYQIPMRIYDADGGLIAEFGEKRRFPVTYAELPKVVVDAFTSAEDGGFFEHGGVDVQSLFRAAYELVKTGHKGQGGSTITMQVARNFFLGRQKTYSRKLMEILLAIKIEHTLSKEQILTLYLNKIFLGNRTYGVKAAAQVYFGKSLDKLTVAEAAMLASLPKAPSSVNPVSNPDKALARRAYVLGRMLALGKIDQASYDQAMQEPLPGHLFASSEIQTRAPFVAEMIRQKLFAQYGEKAYEMGLVVHTSINPKAQQVARMSLRDGLIAYDRRHGYRGAEDHWGSLLSDPKALLDKLQDTPVVGGLIPAVVLSVDPKTAVVLMPDGSKNSLGMDAVSWACRYESTDHCGPKPKLMGDVLKAGDLIRLQAEADQHWMLAEIPAASAGFVALDPETGAIRALVGGFDFAHDSKFNHVTQAERQPGSGFKPFLYSAALDHGFTLATMINDSPVVVKNGVKEGVDWRPQNYEKHFGGPMRLRMALVHSVNLVSIRLIEALGPENVLKYASRFGLPTQNWSPTPSMALGSYTLTPLELVGGFSAFVNGGFRITPYVITEVDNGDNAVLYSHPSVNLCDTCPMDSPDPSVAPRIITPQNAFLMRSALRDVVRMGTGVRAYRALKRDDIGGKTGTTNEQRDAWFTGFGPGWVATAWVGFDDNSPLGHREVGGTAALPIWTDFMKVMLPPPTDKPHVPPPGVTEVMINPDTGNRLPKGASGGVREYFDTTRGPADESGLSAPIPADVVPQNLMNDLF

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP001801
EMBL· GenBank· DDBJ
ACX96758.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

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