D0KN36 · D0KN36_SACS9

Function

function

Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.

Catalytic activity

Cofactor

[4Fe-4S] cluster (UniProtKB | Rhea| CHEBI:49883 )

Note: Binds 1 [4Fe-4S] cluster per subunit.

Pathway

Amino-acid biosynthesis; L-leucine biosynthesis; L-leucine from 3-methyl-2-oxobutanoate: step 2/4.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site298[4Fe-4S] cluster (UniProtKB | ChEBI)
Binding site356[4Fe-4S] cluster (UniProtKB | ChEBI)
Binding site359[4Fe-4S] cluster (UniProtKB | ChEBI)

GO annotations

AspectTerm
Molecular Function3-isopropylmalate dehydratase activity
Molecular Function4 iron, 4 sulfur cluster binding
Molecular Functionmetal ion binding
Biological ProcessL-leucine biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    3-isopropylmalate dehydratase large subunit
  • EC number
  • Alternative names
    • Alpha-IPM isomerase
      (IPMI
      )
    • Isopropylmalate isomerase

Gene names

    • Name
      leuC
    • Ordered locus names
      Ssol_0275

Organism names

Accessions

  • Primary accession
    D0KN36

Interaction

Subunit

Heterodimer of LeuC and LeuD.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain9-282Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha
Domain284-407Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha

Sequence similarities

Belongs to the aconitase/IPM isomerase family. LeuC type 2 subfamily.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    415
  • Mass (Da)
    45,063
  • Last updated
    2009-12-15 v1
  • Checksum
    1365CB8BC85083E8
MSAKTLTEKILSRASGKDVSPGDVIEAKVDLVAFHDLTGYHVIEVMEKANMIKVFDKSKLVIAFDHLAPPPDVRSAEIQGYIRKFVKSEGIPNFYDINYGILHEVMIEQYANPGQVILAADSHTTTSGAVGAFAQGMGASDIAAAVITGKTWLVVPQPFKVVLEGKPAKWITGKDVALKLLGDFKADYFNGMTLEIFVKDPLSFPMDYRATVSNMGIEMNADALMFVPDQETKRYIKEMRGYEPELVTPDNGAKYVDEYTIQLDKMEPLVAAPHSVDNVKVVNELEGTPVDQVYIGSCTNGRLSDFEIAAKIMKGKKVKSRCIAIPASYRMFKEALERGYIQTLVDAGCIVTYGTCGPCLGGHFGIAGPGENIVSTSSRNFKGRMGSNEAKIYLSGPAVAAISALEGKIADPRVV

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP001800
EMBL· GenBank· DDBJ
ACX90571.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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