D0EXD3 · AFP_PENCH

Function

function

Antifungal protein that acts as an inhibitor of growth of human pathogenic molds and yeasts (PubMed:19683356, PubMed:29379111).
Is active against the model organism Neurospora crassa, the opportunistic human pathogens Aspergillus fumigatus, Trichophyton rubrum, and Aspergillus terreus (PubMed:29379111).
Provokes a reduction of the incidence of infections caused by Penicillium digitatum and Penicillium italicum in oranges and by Penicillium expansum in apples (PubMed:34199956).
Low doses of pafB have self-inhibition activity (PubMed:29379111).
Shows also activity against the model yeast Saccaromyces cerevisiae and the opportunistic human pathogen Candida albicans (PubMed:29379111, PubMed:35499318).
No antibacterial activity is observed on the Gram-negative Escherichia coli and the Gram-positive Bacillus subtilis (PubMed:29379111).
Finally, shows also anti-viral activity in a model of HCoV 229E infected L132 cells (PubMed:29379111).

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentextracellular region
Cellular Componenthost cell cytoplasm
Biological Processdefense response to fungus
Biological Processkilling of cells of another organism

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Antifungal protein B

Gene names

    • Name
      pafB

Organism names

  • Taxonomic identifier
  • Strain
    • RP42C
  • Taxonomic lineage
    Eukaryota > Fungi > Dikarya > Ascomycota > Pezizomycotina > Eurotiomycetes > Eurotiomycetidae > Eurotiales > Aspergillaceae > Penicillium > Penicillium chrysogenum species complex

Accessions

  • Primary accession
    D0EXD3

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for signal, propeptide, chain, disulfide bond.

TypeIDPosition(s)Description
Signal1-18
PropeptidePRO_000039170119-34
ChainPRO_000039170235-92Antifungal protein B
Disulfide bond42↔70
Disulfide bond49↔77
Disulfide bond62↔88

Keywords

Expression

Induction

Expression is strongly induced under nutrient excess during the logarithmic growth phase, whereas it remains under the detection level in the supernatant of cultures grown under nutrient limitation.

Family & Domains

Sequence similarities

Belongs to the antifungal protein pafB family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Sequence processing
    The displayed sequence is further processed into a mature form.
  • Length
    92
  • Mass (Da)
    10,119
  • Last updated
    2009-11-24 v1
  • Checksum
    8F7DF4D5B4473E5A
MQITSIAIVFFAAMGAVANPIARESDDLDARDVQLSKFGGECSLKHNTCTYLKGGKNHVVNCGSAANKKCKSDRHHCEYDEHHKRVDCQTPV

Mass Spectrometry

Molecular mass is 6,494 Da. Determined by Electrospray.

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
GQ911150
EMBL· GenBank· DDBJ
ACX54052.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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