D0C9N8 · CNTB_ACIB2
- ProteinCarnitine monooxygenase reductase subunit
- GenecntB
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids318 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score4/5
Function
function
Converts carnitine to trimethylamine and malic semialdehyde.
Catalytic activity
- (R)-carnitine + NADH + O2 + H+ = (3R)-3-hydroxy-4-oxobutanoate + trimethylamine + NAD+ + H2O
Cofactor
Protein has several cofactor binding sites:
Note: Binds 1 2Fe-2S cluster.
Pathway
Amine and polyamine metabolism; carnitine metabolism.
Features
Showing features for binding site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 267 | [2Fe-2S] cluster (UniProtKB | ChEBI) | |||
Binding site | 272 | [2Fe-2S] cluster (UniProtKB | ChEBI) | |||
Binding site | 275 | [2Fe-2S] cluster (UniProtKB | ChEBI) | |||
Binding site | 305 | [2Fe-2S] cluster (UniProtKB | ChEBI) | |||
GO annotations
Aspect | Term | |
---|---|---|
Molecular Function | 2 iron, 2 sulfur cluster binding | |
Molecular Function | metal ion binding | |
Molecular Function | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen | |
Biological Process | carnitine metabolic process |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameCarnitine monooxygenase reductase subunit
- EC number
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageBacteria > Pseudomonadota > Gammaproteobacteria > Moraxellales > Moraxellaceae > Acinetobacter > Acinetobacter calcoaceticus/baumannii complex
Accessions
- Primary accessionD0C9N8
Proteomes
Phenotypes & Variants
Disruption phenotype
Mutant cannot grow on carnitine as a sole carbon and energy source, whereas the growth on succinate is not affected. Mutation abolishes trimethylamine formation from carnitine.
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Chain | PRO_0000442688 | 1-318 | Carnitine monooxygenase reductase subunit | ||
Interaction
Subunit
Composed of an oxygenase subunit (cntA) and a reductase subunit (cntB).
Structure
Sequence
- Sequence statusComplete
- Length318
- Mass (Da)35,538
- Last updated2009-11-24 v1
- Checksum9D5C7FE49B27D0EF
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
GG704573 EMBL· GenBank· DDBJ | EEX03957.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
APRG01000016 EMBL· GenBank· DDBJ | ENW73703.1 EMBL· GenBank· DDBJ | Genomic DNA |