D0C9N8 · CNTB_ACIB2

Function

function

Converts carnitine to trimethylamine and malic semialdehyde.

Catalytic activity

Cofactor

Protein has several cofactor binding sites:
FMN (UniProtKB | Rhea| CHEBI:58210 )

[2Fe-2S] cluster (UniProtKB | Rhea| CHEBI:190135 )

Note: Binds 1 2Fe-2S cluster.

Pathway

Amine and polyamine metabolism; carnitine metabolism.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site267[2Fe-2S] cluster (UniProtKB | ChEBI)
Binding site272[2Fe-2S] cluster (UniProtKB | ChEBI)
Binding site275[2Fe-2S] cluster (UniProtKB | ChEBI)
Binding site305[2Fe-2S] cluster (UniProtKB | ChEBI)

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Carnitine monooxygenase reductase subunit
  • EC number
  • Alternative names
    • Carnitine monooxygenase beta subunit

Gene names

    • Name
      cntB
    • ORF names
      F911_03117
      , HMPREF0010_01351

Organism names

Accessions

  • Primary accession
    D0C9N8

Proteomes

Phenotypes & Variants

Disruption phenotype

Mutant cannot grow on carnitine as a sole carbon and energy source, whereas the growth on succinate is not affected. Mutation abolishes trimethylamine formation from carnitine.

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00004426881-318Carnitine monooxygenase reductase subunit

Interaction

Subunit

Composed of an oxygenase subunit (cntA) and a reductase subunit (cntB).

Structure

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain5-107FAD-binding FR-type
Domain233-3182Fe-2S ferredoxin-type

Sequence similarities

Belongs to the PDR/VanB family. CntB subfamily.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    318
  • Mass (Da)
    35,538
  • Last updated
    2009-11-24 v1
  • Checksum
    9D5C7FE49B27D0EF
MASHYEMFPAVVTRVEQLTPLIKRFTFKRQDGQNFPRFSGGSHIIVKMNEQLSNAYSLMSCTQDLSTYQVCVRKDVEGKGGSVFMHDQCNEGCEIQISEPKNLFPLAETGNKHILIAGGIGITPFLPQMDELAARGAEYELHYAYRSPEHAALLDELTQKHAGHVFSYVDSEGSMLNLDELISSQPKGTHVYVCGPKPMIDAVIDCCNKHRYRDEYIHWEQFASTVPEDGEAFTVVLAKSNQEIEVQSNQTILQAIETLNIDVECLCREGVCGTCETAILEGEAEHFDQYLSDAEKASQKSMMICVSRAKGKKLVLDL

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
GG704573
EMBL· GenBank· DDBJ
EEX03957.1
EMBL· GenBank· DDBJ
Genomic DNA
APRG01000016
EMBL· GenBank· DDBJ
ENW73703.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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