D0A4N5 · D0A4N5_TRYB9

Function

function

Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function.

Features

Showing features for binding site.

170450100150200250300350400450500550600650700
TypeIDPosition(s)Description
Binding site32ATP (UniProtKB | ChEBI)
Binding site36ATP (UniProtKB | ChEBI)
Binding site78ATP (UniProtKB | ChEBI)
Binding site83ATP (UniProtKB | ChEBI)
Binding site91ATP (UniProtKB | ChEBI)
Binding site98-99ATP (UniProtKB | ChEBI)
Binding site118-123ATP (UniProtKB | ChEBI)
Binding site169ATP (UniProtKB | ChEBI)
Binding site375ATP (UniProtKB | ChEBI)

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentcytosol
Cellular Componentperinuclear region of cytoplasm
Cellular Componentplasma membrane
Cellular Componentprotein-containing complex
Molecular FunctionATP binding
Molecular FunctionATP hydrolysis activity
Molecular FunctionATP-dependent protein folding chaperone
Molecular Functionunfolded protein binding
Biological Processcellular response to heat
Biological Processprotein stabilization

Keywords

Names & Taxonomy

Protein names

  • Submitted names
    • Heat shock protein 83

Gene names

    • ORF names
      TbgDal_X13260
      , TbgDal_X13270
      , TbgDal_X13280

Organism names

Accessions

  • Primary accession
    D0A4N5

Proteomes

Organism-specific databases

Subcellular Location

Keywords

Interaction

Subunit

Homodimer.

Structure

Family & Domains

Features

Showing features for domain, region, compositional bias, coiled coil.

TypeIDPosition(s)Description
Domain25-179Histidine kinase/HSP90-like ATPase
Region210-252Disordered
Compositional bias213-227Acidic residues
Compositional bias228-252Basic and acidic residues
Coiled coil526-553
Region678-704Disordered
Compositional bias688-704Polar residues

Sequence similarities

Belongs to the heat shock protein 90 family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    704
  • Mass (Da)
    80,777
  • Last updated
    2009-11-24 v1
  • Checksum
    F200F91B2D1AC176
MTETFAFQAEINQLMSLIINTFYSNKEIFLRELISNSSDACDKIRYQSLTNQSVLGDEPHLRIRVIPDRVNKTLTVEDSGIGMTKADLVNNLGTIARSGTKSFMEALEAGGDMSMIGQFGVGFYSAYLVADRVTVVSKNNEDDAYTWESSAGGTFTVTSTPDCDLKRGTRIVLHLKEDQQEYLEERRLKDLIKKHSEFIGYDIELMVENTTEKEVTDEDEDEEAAKKAEEGEEPKVEEVKDGDDADAKKKKTKKVKEVKQEFVVQNKHKPLWTRDPKDVTKEEYASFYKAISNDWEEQLSTKHFSVEGQLEFRAILFLPKRAPFDMFEPNKKRNNIKLYVRRVFIMDNCEDLCPEWLGFLRGVVDSEDLPLNISRENLQQNKILKVIRKNIVKKALELFEELAENKEDYKKFYEQFSKNVKLGIHEDSTNRKKLMELLRFHSSESGEEMTTLKDYVTRMKEGQKCIYYVTGDSKKKLETSPFIEQAKRRGMEVLFMTDPIDEYVMQQVKDFEDKKFACLTKEGVHFEETEEEKKQREEEKASYERLCKAMKEVLGDKVEKVVVSDRLATSPCILVTSEFGWSAHMEQIMRNQALRDSSMSAYMMSKKTMEINTTHAIVKELKRRVEADENDKAAKDLIFLLFDTSLLTSGFTLDDPTAYADRIHRMIKLGLSLDDDAEEEEAQAPVAAAAANSSTGASGMEEVD

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias213-227Acidic residues
Compositional bias228-252Basic and acidic residues
Compositional bias688-704Polar residues

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
FN554973
EMBL· GenBank· DDBJ
CBH16229.1
EMBL· GenBank· DDBJ
Genomic DNA
FN554973
EMBL· GenBank· DDBJ
CBH16230.1
EMBL· GenBank· DDBJ
Genomic DNA
FN554973
EMBL· GenBank· DDBJ
CBH16231.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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