C9Y0Q0 · SULA_CROTZ

Function

function

Component of the SOS system and an inhibitor of cell division. Accumulation of SulA causes rapid cessation of cell division and the appearance of long, non-septate filaments. In the presence of GTP, binds a polymerization-competent form of FtsZ in a 1:1 ratio, thus inhibiting FtsZ polymerization and therefore preventing it from participating in the assembly of the Z ring. This mechanism prevents the premature segregation of damaged DNA to daughter cells during cell division.

Features

Showing features for site.

116820406080100120140160
TypeIDPosition(s)Description
Site168Essential for degradation by Lon protease

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Biological Processdivision septum assembly
Biological Processnegative regulation of cell division
Biological ProcessSOS response

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Cell division inhibitor SulA

Gene names

    • Name
      sulA
    • Ordered locus names
      Ctu_15660

Organism names

Accessions

  • Primary accession
    C9Y0Q0

Proteomes

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00004142431-168Cell division inhibitor SulA

Post-translational modification

Is rapidly cleaved and degraded by the Lon protease once DNA damage is repaired.

Expression

Induction

By DNA damage, as part of the SOS response.

Interaction

Subunit

Interacts with FtsZ.

Structure

Family & Domains

Features

Showing features for region.

TypeIDPosition(s)Description
Region105-111FtsZ binding
Region161-168Lon protease binding

Sequence similarities

Belongs to the SulA family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    168
  • Mass (Da)
    19,270
  • Last updated
    2011-12-14 v2
  • Checksum
    62F5DFC1575A551F
MYFSHQNRAHGSRRLAKETADALAQAETRGLISEVMYNEDQPRMTQMVLLPLLQQLGLQSRWQLWLTPQQRLSREWVESAGLPLTKVMQVSQMNPQVTLDSMIRALETGNYSVVIAWLHDDLTDDEHRRLTEAAEKGNAMGFLMRPVQPSLPGDRPRSGLRIHSRMVH

Sequence caution

The sequence CBA29741.1 differs from that shown. Reason: Erroneous initiation Truncated N-terminus.

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
FN543093
EMBL· GenBank· DDBJ
CBA29741.1
EMBL· GenBank· DDBJ
Genomic DNA Different initiation

Genome annotation databases

Similar Proteins

Disclaimer

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