C9XWA4 · C9XWA4_CROTZ
- ProteinUridylate kinase
- GenepyrH
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids241 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Catalyzes the reversible phosphorylation of UMP to UDP.
Catalytic activity
- ATP + UMP = ADP + UDP
Activity regulation
Allosterically activated by GTP. Inhibited by UTP.
Pathway
Pyrimidine metabolism; CTP biosynthesis via de novo pathway; UDP from UMP (UMPK route): step 1/1.
Features
Showing features for binding site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 15-18 | ATP (UniProtKB | ChEBI) | ||||
Sequence: KLSG | ||||||
Binding site | 57 | UMP (UniProtKB | ChEBI) | ||||
Sequence: G | ||||||
Binding site | 58 | ATP (UniProtKB | ChEBI) | ||||
Sequence: G | ||||||
Binding site | 62 | ATP (UniProtKB | ChEBI) | ||||
Sequence: R | ||||||
Binding site | 77 | UMP (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 138-145 | UMP (UniProtKB | ChEBI) | ||||
Sequence: TGNPFFTT | ||||||
Binding site | 165 | ATP (UniProtKB | ChEBI) | ||||
Sequence: T | ||||||
Binding site | 171 | ATP (UniProtKB | ChEBI) | ||||
Sequence: Y | ||||||
Binding site | 174 | ATP (UniProtKB | ChEBI) | ||||
Sequence: D |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Molecular Function | ATP binding | |
Molecular Function | UMP kinase activity | |
Biological Process | 'de novo' CTP biosynthetic process |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameUridylate kinase
- EC number
- Short namesUK
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageBacteria > Pseudomonadota > Gammaproteobacteria > Enterobacterales > Enterobacteriaceae > Cronobacter
Accessions
- Primary accessionC9XWA4
Proteomes
Subcellular Location
Interaction
Subunit
Homohexamer.
Structure
Family & Domains
Features
Showing features for domain, region.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 10-219 | Aspartate/glutamate/uridylate kinase | ||||
Sequence: KRILLKLSGEALQGAEGFGIDASILDRMAQEIKELVELGIQVGVVIGGGNLFRGAGLAKAGMNRVVGDHMGMLATVMNGLAMRDALHRAYVNARLMSAFPLNGVCDNYSWAEAISLLRNNRVVILSAGTGNPFFTTDSAACLRGIEIEAEVVLKATKVDGVYSADPMKDPTATLYDQLSYQEVLEKELKVMDLAAFTLARDHKLPIRVFN | ||||||
Region | 23-28 | Involved in allosteric activation by GTP | ||||
Sequence: GAEGFG |
Sequence similarities
Belongs to the UMP kinase family.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length241
- Mass (Da)26,072
- Last updated2009-11-24 v1
- ChecksumF4E8A4CE92823C73
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
FN543093 EMBL· GenBank· DDBJ | CBA28181.1 EMBL· GenBank· DDBJ | Genomic DNA |