C9XWA4 · C9XWA4_CROTZ

Function

function

Catalyzes the reversible phosphorylation of UMP to UDP.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.

Catalytic activity

Activity regulation

Allosterically activated by GTP. Inhibited by UTP.

Pathway

Pyrimidine metabolism; CTP biosynthesis via de novo pathway; UDP from UMP (UMPK route): step 1/1.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site15-18ATP (UniProtKB | ChEBI)
Binding site57UMP (UniProtKB | ChEBI)
Binding site58ATP (UniProtKB | ChEBI)
Binding site62ATP (UniProtKB | ChEBI)
Binding site77UMP (UniProtKB | ChEBI)
Binding site138-145UMP (UniProtKB | ChEBI)
Binding site165ATP (UniProtKB | ChEBI)
Binding site171ATP (UniProtKB | ChEBI)
Binding site174ATP (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular FunctionATP binding
Molecular FunctionUMP kinase activity
Biological Process'de novo' CTP biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Uridylate kinase
  • EC number
  • Short names
    UK
  • Alternative names
    • Uridine monophosphate kinase
      (UMP kinase
      ; UMPK
      )

Gene names

    • Name
      pyrH
    • Ordered locus names
      Ctu_07990

Organism names

Accessions

  • Primary accession
    C9XWA4

Proteomes

Subcellular Location

Keywords

Interaction

Subunit

Homohexamer.

Family & Domains

Features

Showing features for domain, region.

TypeIDPosition(s)Description
Domain10-219Aspartate/glutamate/uridylate kinase
Region23-28Involved in allosteric activation by GTP

Sequence similarities

Belongs to the UMP kinase family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    241
  • Mass (Da)
    26,072
  • Last updated
    2009-11-24 v1
  • Checksum
    F4E8A4CE92823C73
MATNAKPVYKRILLKLSGEALQGAEGFGIDASILDRMAQEIKELVELGIQVGVVIGGGNLFRGAGLAKAGMNRVVGDHMGMLATVMNGLAMRDALHRAYVNARLMSAFPLNGVCDNYSWAEAISLLRNNRVVILSAGTGNPFFTTDSAACLRGIEIEAEVVLKATKVDGVYSADPMKDPTATLYDQLSYQEVLEKELKVMDLAAFTLARDHKLPIRVFNMNKPGALRRVVMGEKEGTLITE

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
FN543093
EMBL· GenBank· DDBJ
CBA28181.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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